Association of ki67 Index with Recurrence in Gastrointestinal Stromal Tumors

Segales-Rojas, Patricia; Lino-Silva, Leonardo S.; Aguilar-Cruz, Eduardo; Salcedo‐Hernández, Rosa A.

doi:10.1007/s12029-018-0150-z

Cited by 9 publications

(9 citation statements)

References 11 publications

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“…Seagles-Rojas et al conducted a study to investigate the effect of Ki-67 index on GIST recurrence with 43 patients in 2018. In this study, Ki-67 had no effect on recurrence, but male gender and tumor size had ef-fect on recurrence (16). Like this study we found that Ki-67 have no relation with recurrence.…”

Section: Discussionsupporting

confidence: 63%

Gastrointestinal Stromal Tümör Rekürrensinde Risk Faktörleri

Ekinci

Leblebici

Acar

et al. 2021

Anadolu Kliniği Tıp Bilimleri Dergisi

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Aim: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasia of gastrointestinal system. Radical surgery with negative margin is the most important step for treatment of GIST. The primary aim of this study was to evaluate the risk factors for recurrence in patients who underwent surgery with diagnosis of GIST. Secondary aim was to reveal the factors that affect survival. Materials and Methods: The data of 28 GIST patients who underwent surgery in our clinic between January 2013 and August 2019 were analyzed retrospectively. Patients preoperative radiological images, histopathological and immunohistochemical findings were noted. Results: Eighteen patients were male, and ten patients were female. Median age was 64.5 (range; 50-87). Twenty-six patients (92.2%) underwent open surgery and 2 patients (7.1%) underwent laparoscopic surgery. Fifteen (53.6%) of the 28 tumors were located in the stomach, 10 (35.7%) in the small intestine, 2 (7.1%) in the duodenum and 1 (3.6%) was located multifocal. Mean tumor diameter was 10.1 cm (range; 0.5-21). The number of patients with recurrence was 5 (17.9%). Tumor with necrosis, tumor located in an organ other than the stomach, and the high number of tumor mitosis revealed a significant difference for recurrence. In addition, large tumor size revealed significant statistical difference for recurrence. The median follow-up period was 26 (3-60) months. Necrosis of tumor and tumor type were the factors that significantly shortened survival. Conclusion:In this study which we examined the GIST recurrence, it was observed that tumor size, tumor necrosis, increased number of mitosis and tumors located in an organ other than stomach are risk factors for recurrence. In this study which we examined GIST recurrence, tumor size, tumor necrosis, increased number of mitoses and tumors located in an organ other than the stomach are found to be risk factors for recurrence. It was observed that the factors affecting the survival times, which are the secondary aim of the study, were cell type and tumor necrosis.

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Section: Discussionsupporting

confidence: 63%

Gastrointestinal Stromal Tümör Rekürrensinde Risk Faktörleri

Ekinci

Leblebici

Acar

et al. 2021

Anadolu Kliniği Tıp Bilimleri Dergisi

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“…Only four GISTs were analyzed for mutations at the time of the diagnosis, and all were negative for KIT and PDGFRA mutations. At the time of diagnosis, six of the eight GISTs were estimated to have a high risk for malignant behavior (size over >5 cm, and >5 mitoses per 50 high‐power microscopic fields, or Ki67 >5%), whereas the risk was low in two patients suggesting benign prognosis (Li et al, ; von Mehren & Joensuu, ; Segales‐Rojas, Lino‐Silva, Aguilar‐Cruz, & Salcedo‐Hernández, ; Zhou et al, ). However, the two NF1 patients with the low‐risk primary tumors in the duodenal localization died of GIST within one year of diagnosis.…”

Section: Resultsmentioning

confidence: 99%

Intestinal tumors in neurofibromatosis 1 with special reference to fatal gastrointestinal stromal tumors (GIST)

Ylä‐Outinen

Loponen

Kallionpää

et al. 2019

Molec Gen & Gen Med

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Background Type 1 neurofibromatosis (NF1) is a genetic tumor predisposing Rasopathy. NF1 patients have an increased risk for developing benign and malignant tumors, but the occurrence of intestinal tumors has not been investigated at the population level. Methods In this retrospective register‐based total population study, diagnoses of gastrointestinal tract tumors were retrieved from the Finnish Care Register for Health Care for 1,410 NF1 patients and 14,030 reference persons. We also reviewed the death certificates of 232 NF1 patients who died during years 1987–2013, and specifically searched for diagnosis of gastrointestinal stromal tumor (GIST). Results The register analysis revealed an increased overall hazard ratio (HR) of 2.6 (95% CI 1.9–3.6) for intestinal tumors in NF1 compared to general population. The highest HR of 15.6 (95% CI 6.9–35.1) was observed in the small intestine. The focused analysis of NF1 death certificates and GISTs demonstrated that the GIST was the primary cause of death in seven patients. Conclusion This study emphasizes the need for careful evaluation of NF1 patients with gastrointestinal complaints. The challenge in diagnosis is that the tumors preferably occur at the small intestine, which is difficult target for diagnostic procedures. We also show that the NF1 GISTs may lead to fatal outcome despite of benign histopathological findings at the time of the diagnosis.

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“…We found that the negative rate was as high as 22.09% in non-gastric tumors, and the negative rate from gastric sources was 0.59%. A study has shown that different sources of stromal tumors have different biological characteristics (25), and that lesions derived from the stomach have a better prognosis (26). Another study showed that CD34 has a high negative rate in large lesions, with the highest negative rate (13.04%) in the >10 cm group and the lowest negative rate (0%) in the ≤2 cm group (9).…”

Section: Relevance Of the Layer Of Invasion To Ki67mentioning

confidence: 99%

Associations of CD34, Ki67, layer of invasion and clinical pathological characteristics, prognosis outcomes in gastrointestinal stromal tumors—a retrospective cohort study

Yang¹,

Xing²,

Zhang³

et al. 2022

Transl Cancer Res TCR

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Background: Gastrointestinal stromal tumors (GIST) is the most common interstitial tumor of the digestive tract. GIST, like other malignancies, can recur, metastasize, and even metastasize to the brain, leading to death. Therefore, the prevention and treatment of GIST is very important. The clinical features of GIST are uniquely different to those of other common malignancies. Therefore, it is of great significance to explore the relationship between the pathological features and prognosis of GIST to strengthen the prevention and treatment of GIST. The objectives of this study were to study the clinical features of Ki67, Cluster Differentiation 34 (CD34), and their correlations in the Jianghuai region of China in recent years, and to analyze their relationship with prognosis.Methods: A total of 423 cases of GIST in Northern Jiangsu People's Hospital in Yangzhou from 2013 to 2020 were retrospectively analyzed. The data of CD34, Ki67 and layer of invasion was collected, and their associations with the clinical pathological characteristics, prognosis outcomes of GIST were studied. CD34 and Ki67 were tested by immunohistochemistry (IHC) And data was analyzed by chi-square test, t-test, Kaplan-Meier (KM) method survival curve, Log-rank test, and Cox regression. Results:The results showed that CD34 was associated with the clinical features of primary site, tumor size, risk, recurrence, and progression-free survival (PFS) (P<0.001, =0.01, <0.001, =0.039 and =0.018), but not with nuclear division or overall survival (OS) (P>0.05). Further, Ki67 was associated with nuclear division, tumor size, risk, recurrence, and PFS (P<0.001, <0.001, <0.001, <0.001 and <0.001), but there was no significant correlation with the primary site and CD34 (P>0.05), and Ki67 was associated with OS, but there was no statistical significance (P=0.0507). The layer of invasion was associated with the primary site, nuclear

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Association of ki67 Index with Recurrence in Gastrointestinal Stromal Tumors

Abstract: We did not find an association of the ki67 index with recurrence. The factors associated with recurrence were a high tumor size (> 10 cm) and male sex.

Cited by 9 publications

References 11 publications

Gastrointestinal Stromal Tümör Rekürrensinde Risk Faktörleri

Gastrointestinal Stromal Tümör Rekürrensinde Risk Faktörleri

Intestinal tumors in neurofibromatosis 1 with special reference to fatal gastrointestinal stromal tumors (GIST)

Associations of CD34, Ki67, layer of invasion and clinical pathological characteristics, prognosis outcomes in gastrointestinal stromal tumors—a retrospective cohort study

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