Association of Lactate With Blood Pressure Before and After Rapid Weight Loss

Crawford, Stephen O.; Ambrose, Marietta; Hoogeveen, Ron C.; Brancati, Frederick L.; Ballantyne, Christie M.; Young, J. Hunter

doi:10.1038/ajh.2008.282

Cited by 34 publications

(27 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It might be part of the explanation that we examined subjects of normal weight (BMI 22.7 ± 1.5 kg/m 2 ), while Veneman et al examined overweight subjects (BMI 28.1 ± 1 kg/m 2 ). Since overweight individuals display elevated plasma lactate concentrations compared with normal weight subjects, 49 which is also reflected in baseline plasma lactate values (Veneman et al: 1.2 ± 0.2 mmol/l vs our study: 0.84 ± 0.05 mmol/l), a plateau may be reached more quickly in obese subjects. Therefore, we assume that we would have reached a plasma lactate plateau in our study after a longer period of time.…”

Section: Figuresupporting

confidence: 44%

Lactate infusion increases brain energy content during euglycemia but not hypoglycemia in healthy men

Richter¹,

Rabe²,

Duysen³

et al. 2019

NMR in Biomedicine

View full text Add to dashboard Cite

A special characteristic of the brain is the usage of lactate as alternative fuel instead of glucose to preserve its energy homeostasis. This physiological function is valid for sufficient cerebral glucose supply, as well as presumably during hypoglycemia, given that exogenous lactate infusion suppresses hormonal counterregulation. However, it is not yet clarified whether this effect is mediated by the use of lactate as an alternative cerebral energy substrate or any other mechanism. We hypothesized that under conditions of limited access to glucose (ie, during experimental hypoglycemia) lactate infusion would prevent hypoglycemia‐induced neuroenergetic deficits in a neuroprotective way. In a randomized, double‐blind, crossover study, lactate vs placebo infusion was compared during hyperinsulinemic‐hypoglycemic clamps in 16 healthy young men. We measured the cerebral high‐energy phosphate content — ie, adenosine triphosphate (ATP), phosphocreatine (PCr) and inorganic phosphate (Pi) levels — by 31P‐magnetic resonance spectroscopy as well as the neuroendocrine stress response. During euglycemia, lactate infusion increased ATP/Pi as well as PCr/Pi ratios compared with baseline values and placebo infusion. During hypoglycemia, there were no differences between the lactate and the placebo condition in both ratios. Hormonal counterregulation was significantly diminished upon lactate infusion. Our data demonstrate an elevated cerebral high‐energy phosphate content upon lactate infusion during euglycemia, whereas there was no such effect during experimental hypoglycemia. Nevertheless, lactate infusion suppressed hypoglycemic hormonal counterregulation. Lactate thus adds to cerebral energy provision during euglycemia and may contribute to an increase in ATP reserves, which in turn protects the brain against neuroglucopenia under recurrent hypopglycemic conditions, eg, in diabetic patients.

show abstract

Section: Figuresupporting

confidence: 44%

Lactate infusion increases brain energy content during euglycemia but not hypoglycemia in healthy men

Richter¹,

Rabe²,

Duysen³

et al. 2019

NMR in Biomedicine

View full text Add to dashboard Cite

show abstract

“…Accordingly, an increase in [LAC] could be an indicator of impaired glucose metabolism. In fact, fasting [LAC] is higher in people with obesity ( 1 , 2 ) and type 2 diabetes ( 3 , 4 , 5 ) than in healthy lean people. An increase in [LAC] can also influence glucose metabolism by providing a gluconeogenic precursor to the liver and by disrupting muscle insulin signaling and insulin-mediated muscle glucose uptake ( 6 , 7 , 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial

Chondronikola

Magkos

Yoshino

et al. 2018

Obesity

View full text Add to dashboard Cite

ObjectiveLactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after manipulating insulin sensitivity by progressive weight loss.MethodsForty people with obesity (BMI=37.9±4.3 kg/m2) were randomized to weight maintenance (n=14) or weight loss (n=19). Subjects were studied before and after 6 months of weight maintenance and before and after 5%, 11% and 16% weight loss. A hyperinsulinemic-euglycemic clamp procedure in conjunction with [6,6-2H2]glucose tracer infusion was used to assess glucose kinetics.ResultsAt baseline, fasting [LAC] correlated positively with endogenous glucose production rate (r=0.532, p=0.001) and negatively with insulin sensitivity, assessed as the insulin-stimulated glucose disposal (r=−0.361, p=0.04). Progressive (5% through 16%) weight loss caused a progressive decrease in fasting [LAC], and the decrease in fasting [LAC] after 5% weight loss was correlated with the decrease in endogenous glucose production (r=0.654, p=0.002) and the increase in insulin sensitivity (r=−0.595, p=0.007).ConclusionThis study demonstrates the inter-relationships among weight loss, hepatic and muscle glucose kinetics, insulin sensitivity, and [LAC], and suggests that [LAC] can serve as an additional biomarker of glucose-related insulin resistance.

show abstract

“…Acutely, higher lactate levels indicate insufficient oxidative capacity to meet energy expenditure, such as during exercise. Higher blood lactate levels have been previously observed with obesity in several studies (29)(30)(31), which could be due to either higher energy demand associated with higher free fat mass (32), or associated mitochondrial dysfunction (33,34), or both. Another metabolite observed to be positively associated with weight change in our study, alanine, also provides a substrate for oxidative metabolism via the Krebs cycle.…”

Section: Discussionmentioning

confidence: 98%

Serum Molecular Signatures of Weight Change during Early Breast Cancer Chemotherapy

Keun

Sidhu

Pchejetski

et al. 2009

Clinical Cancer Research

View full text Add to dashboard Cite

Purpose: Weight gain in women receiving chemotherapy for breast cancer is associated with a higher risk of recurrence but its mechanisms are poorly understood. Experimental Design: To investigate this, we assessed the metabolic, cytokine, and appetite-related peptide alterations during adjuvant chemotherapy for early breast cancer in postmenopausal women, and correlated these with body mass measurements. Specifically, we performed global metabolic profiling using 1 H-nuclear magnetic resonance spectroscopy of sequential sera, examined ghrelin immunoreactivity, RIAs for GLP-1 and peptide YY, and electrochemiluminescent cytokine analyses (tumor necrosis factor-α and interleukin-6) on sequential samples. Results: In those who gained >1.5 kg, several metabolite levels were positively associated with weight gain, specifically lactate, which was 63.5% greater in patients with increased body weight during chemotherapy compared with those with no weight gain (P < 0.01; the prespecified primary end point). A strong correlation (r = 0.7, P < 0.001) was detected between the rate of weight change and serum lactate levels, and on average, lactate levels exhibited the greatest metabolic response to chemotherapy, increasing by up to 75%. Normalized levels of peptide YY were also observed to be elevated in patients not gaining weight posttreatment (+30% compared with -7% for the weight gain group; P < 10 -4 ). Baseline lactate, alanine, and body fat were all prognostic for weight gain (area under the receiver operator characteristic curves, >0.77; P < 0.05). No associations were observed between any other parameter and weight gain, including cytokine levels. Conclusions: Metabonomics identifies excess energy expenditure pathways perturbed during chemotherapy for breast cancer, and establishes a significant association between serum lactate, body fat, and substantive weight gain during chemotherapy. (Clin Cancer Res 2009;15(21):6716-23)

show abstract

Association of Lactate With Blood Pressure Before and After Rapid Weight Loss

Cited by 34 publications

References 36 publications

Lactate infusion increases brain energy content during euglycemia but not hypoglycemia in healthy men

Lactate infusion increases brain energy content during euglycemia but not hypoglycemia in healthy men

Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial

Serum Molecular Signatures of Weight Change during Early Breast Cancer Chemotherapy

Contact Info

Product

Resources

About