Association of laryngopharyngeal manifestations and gatroesophageal reflux

Abstract

The aim of this study was to investigate the prevalence of gastroesophageal reflux disease (GERD) in patients with laryngopharyngeal symptoms, the relationship between laryngopharyngeal reflux (LPR) and Helicobacter Pylori infection and treatment response to proton pump inhibitors. Forty-five patients with suspected gastroesophageal reflux diseases related symptoms (sore throat, throat burning, throat clearing, globus sensation, cough, halitozis, dysphonia, dysphagia, postnasal dripping, vocal fatigue, and sputum) were included in this study. For pre-therapeutic and post-therapeutic comparison, symptoms and laryngological findings were graded on a 4-point scale. The patients underwent upper gastrointestinal system endoscopy. During endoscopy, antral biopsies from the stomach were obtained to detect H. Pylori. Antireflux medication with proton pump inhibitors (PPI) and H. Pylori eradication therapy if present were prescribed to the patients. The improvement in symptoms and laryngological findings were evaluated after treatment. By means of esophagogastroduodenoscopy (EGD), reflux was detected in only 11% of patients. But there can be reflux patients other than the detected ones. Although, H. Pylori was present in 62% of patients, no correlation was found between H. Pylori positivity and symptoms. All patients responded well to antireflux treatment and H. Pylori eradication therapy. Laryngopharyngeal symptoms and findings can be predictors of gastroesophageal diseases when response to reflux treatment is taken into account.

A clinical study of symptomatic profile and response in objective and subjective parameters to proton pump inhibitor in laryngopharyngeal reflux

“…Several studies on LPR have found globus pharyngeus as the most common symptom, while some studies have found other symptoms of LPR more common like throat burning, hoarseness, cough. [7][8][9][10][11] In our study most common symptom of LPR was found to be frequent clearing of throat in 98%, which was similar in the study by Toros et al 12 Other common symptoms seen in our study were sensation of lump in throat and troublesome cough in 96% of patients each. Dyspnoea/choking (38%) was least common symptom seen our patients.…”

Importance of laryngologic examination in chronic cough

“…Öksürüğün oluşma mekanizması, enflamatuvar proçeslerin öksürük refleksini oluşturan duyu sinirlerini stimüle etmesiyle ilişkilidir. [2,12] Astımda epizodik wheezing, nefes darlığı, göğüste sıkışma hissi, öksürük gibi semptomlar ve dinlemekle ronküsler vardır. Solunum fonksiyon testlerinde (SFT) reversibl havayolu obstrüksiyonu varsa veya metakolin inhalasyonu ile yapılan bronkoprovokasyon testi pozitif ise astım tanısı konur.…”

“…[12] Larengeal muayenede LFR bulguları olan hastalarda ampirik proton pompa inhibitörü kullanımının klinik bulguları etkin bir şekilde önlediğini bildiren yayınlar vardır. [13] Belafsky ve ark.…”

“…[14] Gastroözofageal reflüye eşlik eden bulgular arasın-da kronik öksürük sıklıkla yer almaktadır. Toros ve ark.nın [12] yapmış oldukları çalışmada GÖR olgularının %57.8'inde ılımlı veya orta düzeyde öksürük yakınması olduğu kaydedilmiştir. [12] Bucca ve ark.…”

Zapalne i nowotworowe zmiany błony śluzowej krtani w chorobie refluksowej

“…Wynik ten jest niŜszy od podawanych w literaturze. Toros podaje, Ŝe zaczerwienienie nalewek występowało u prawie 80% pacjentów [143]. Obrzęk błony śluzowej tylnego odcinka krtani widoczny był u wszystkich przebadanych chorych, z czego nieco ponad połowa miała obrzęk łagodny a pozostali bar-dziej nasilone zmiany obrzękowe w krtani.…”