Association of LDL to HDL ratio with new-onset atrial fibrillation after on-pump coronary artery bypass graft surgery

Yu, Ming-Huan; Zhang, Ren-Jian-Zhi; Yu, Xiaoshan; Shi, Jian-Wei; Liu, Zhigang

doi:10.1186/s12872-022-03016-7

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…Previous studies have shown an inverse relationship between the LDL-C/HDL-C ratio and the development of AF, particularly in individuals aged 75 and older 25,32 . Moreover, research involving coronary artery bypass graft patients revealed a higher incidence of postoperative AF with elevated LDL-C/HDL-C ratios, notably in women 33 .…”

Section: Introductionmentioning

confidence: 99%

Association between low-density lipoprotein cholesterol to high- density lipoprotein cholesterol ratio and atrial fibrillation in adults with chronic kidney disease

Guan,

Hu,

et al. 2024

Preprint

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Background: Atrial fibrillation (AF) is more common in patients with chronic kidney disease (CKD). Although a reverse relationship between lipid levels and AF has been suggested, it is uncertain if this link is relevant to CKD patients. This research investigated the association between the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and the risk of AF in individuals with CKD. Methods: Data was collected from 21,091 non-selective, consecutive CKD patients from 2006 to December 31, 2015. We assessed the association between the LDL-C/HDL-C ratio and AF in CKD patients using binary logistic regression, along with a series of sensitivity and subgroup analyses. The dataset supporting these analyses can be accessed at:https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230189. Results: Of the 21,091 CKD patients, 211 (1.00%) were diagnosed with AF. The cohort, predominantly male (79.93%), had a mean age of 60.89 ±10.05 years. The mean LDL-C/HDL-C ratio was 1.39±0.35. After adjusting for covariates, a significant inverse association was observed between the LDL-C/HDL-C ratio and the incidence of AF in CKD patients (OR = 0.422, 95% CI: 0.273-0.652, P = 0.00010). The robustness of these findings was confirmed through sensitivity analysis and subgroup analysis consistently showed a link between the LDL-C/HDL-C ratio and AF, suggesting that confounding factors had little effect on the LDL-C/HDL-C ratio's relationship with AF. Conclusion: Our research demonstrates an independent inverse relationship between the LDL-C/HDL-C ratio and the risk of AF in CKD patients. It is recommended to avoid overly aggressive lowering of LDL levels in CKD patients, as this may increase the risk of developing AF.

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Section: Introductionmentioning

confidence: 99%

Association between low-density lipoprotein cholesterol to high- density lipoprotein cholesterol ratio and atrial fibrillation in adults with chronic kidney disease

Guan,

Hu,

et al. 2024

Preprint

View full text Add to dashboard Cite

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Inverse relationship between LDL-C/HDL-C ratio and atrial fibrillation in chronic kidney disease patients

Guan,

Hu,

et al. 2024

Sci Rep

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Atrial fibrillation (AF) is more prevalent in individuals with chronic kidney disease (CKD) compared to the general population. While a potential inverse correlation between lipid levels and AF has been proposed, it remains unclear if this relationship applies to CKD patients. This study examined the connection between the ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C) and the likelihood of AF in CKD patients. Data was gathered from 21,091 consecutive CKD patients between 2006 and December 31, 2015. We examined the link between the LDL-C/HDL-C ratio and AF in CKD patients through binary logistic regression, as well as various sensitivity and subgroup analyses. The dataset that backs up these analyses is available at: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230189 . Of the 21,091 CKD patients, 211 (1.00%) were diagnosed with AF. The cohort, predominantly male (79.93%), had a mean age of 60.89 ± 10.05 years. The mean LDL-C/HDL-C ratio was 1.39 ± 0.35. After adjusting for covariates, a significant inverse association was observed between the LDL-C/HDL-C ratio and the incidence of AF in CKD patients (OR = 0.422, 95% CI 0.273–0.652, P = 0.00010). The robustness of these findings was confirmed through sensitivity analysis. Subgroup analysis revealed a strong correlation between the LDL-C/HDL-C ratio and incident AF in patients without hypertension (HR = 0.26, 95% CI 0.15–0.45). Conversely, this association was absent in hypertensive patients (HR = 1.09, 95% CI 0.54–2.17). Our research shows an independent inverse correlation between the LDL-C/HDL-C ratio and the risk of AF in CKD patients. It is advised to refrain from excessively aggressive reduction of LDL levels in CKD patients, as this could elevate the risk of developing AF.

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L-shaped association of plasma low-density lipoprotein cholesterol with atrial fibrillation recurrence after catheter ablation: a prospective cohort study

Zou,

Huang,

Huang

et al. 2024

Sci Rep

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The association between plasma low-density lipoprotein cholesterol (LDL-C) and atrial fibrillation (AF) recurrence after catheter ablation remains unclear. We aimed to assess the relationship between preprocedural LDL-C and the AF recurrence in patients undergoing catheter ablation. The cohort study consecutively included AF patients who underwent de novo catheter ablation between April 2021 and January 2023 in the Second Affiliated Hospital of Nanchang University in Jiangxi Province, China. Patients were divided into quartiles based on their baseline fasting LDL-C level (Q1-Q4). Multivariable Cox proportional hazards models were used to evaluate the relationship between LDL-C and AF recurrence. Our analysis included the use of a generalized additive model and smooth curve fitting (penalized spline method), and two-piecewise Cox proportional hazards models, to address the nonlinearity between preprocedural LDL-C and AF recurrence. A total of 482 AF patients with de novo catheter ablation were enrolled, with a median follow-up period of 15.00 months, AF recurrence occurred in 96 (19.92%) patients. The relationship between preprocedural LDL-C and AF recurrence after ablation presented as an L-shape, and the inflection point for the curve was found at the LDL-C level of 3.20 mmol/L (Log likelihood ratio P = 0.031). The hazard ratios (HR) [(95% confidence intervals (CI)] for AF recurrence were 0.50 (0.33–0.74) and 2.11 (0.76–5.89) to the left and right of the inflection point, respectively. Lower LDL-C level is associated with increased AF recurrence risk after catheter ablation were consistent across all subgroups.

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Association of LDL to HDL ratio with new-onset atrial fibrillation after on-pump coronary artery bypass graft surgery

Cited by 3 publications

References 34 publications

Association between low-density lipoprotein cholesterol to high- density lipoprotein cholesterol ratio and atrial fibrillation in adults with chronic kidney disease

Association between low-density lipoprotein cholesterol to high- density lipoprotein cholesterol ratio and atrial fibrillation in adults with chronic kidney disease

Inverse relationship between LDL-C/HDL-C ratio and atrial fibrillation in chronic kidney disease patients

L-shaped association of plasma low-density lipoprotein cholesterol with atrial fibrillation recurrence after catheter ablation: a prospective cohort study

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