Association of lead, cadmium and mercury with paraoxonase 1 activity and malondialdehyde in a general population in Southern Brazil

Lopes, Ana Carolina B. Almeida; Urbano, Mariana Ragassi; Souza-Nogueira, André; Oliveira-Paula, Gustavo H.; Michelin, Ana Paula; Carvalho, Maria de Fátima; Camargo, Alissana Ester Iakmiu; Peixe, Tiago Severo; Cabrera, Marcos Aparecido Sarriá; Paoliello, Mônica Maria Bastos

doi:10.1016/j.envres.2017.04.036

Cited by 20 publications

(5 citation statements)

References 54 publications

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“…Using the proposed search strategy, 152 articles were found in 3 databases and, after the exclusion and the full text evaluation, 13 studies [ 5 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ] were included in this review ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Thus, 8124 individuals were included in this review, 58.8% were males, and ages ranged from 0 to 87 years ( Table 1 ). Four articles studied only children [ 5 , 16 , 22 , 25 ], eight only adults [ 15 , 17 , 18 , 19 , 20 , 21 , 23 , 24 , 26 ] and one both children and adults [ 23 ] ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…TaqMan real-time PCR (69.2%) was the main method used for genotyping analysis. In addition, two articles used TaqMan and another technology [ 17 , 22 ]; two articles from the same group used MassArray technology [ 20 , 24 ], another used a spectrophotometer [ 21 ], and one used RFLP-PCR [ 26 ] ( Table S1 ). According to Dresher and colleagues (2014) [ 17 ], the genotyping error rate of MassArray technology (~0.5%) was higher than TaqMan PCR (~0.1%).…”

Section: Resultsmentioning

confidence: 99%

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Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview

Perini,

Cardoso,

Knesse

et al. 2024

Toxics

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Mercury (Hg) pollution is a global public health concern because of its adverse effects on the environment and health. Single-nucleotide polymorphisms (SNPs) have been associated with Hg levels and outcomes. The aim of this review was to describe the research and discuss the evidence on the genetic susceptibility of Hg-exposed individuals to the development of neurocognitive disorders. A systematic review was performed to identify the genes/SNPs associated with Hg toxicokinetics and that, therefore, affect neurological function in exposed populations. Observational and experimental studies were identified by screening three databases. Thirteen articles were included (quality score 82–100%) and 8124 individuals were evaluated. Hg exposure was mainly fish consumption (77%) and, in 31% of the studies, the Hg levels exceeded the reference limits. Genetic susceptibility to higher Hg levels and neurotoxicity risk in Hg poisoning were associated with eight (ALAD rs1800435, CYP3A4 rs2740574, CYP3A5 rs776746, CYP3A7 rs2257401, GSTP1 rs1695, MT1A rs8052394, MT1M rs2270836, and MT4 rs11643815) and three (MT1A rs8052394, MT1M rs2270837, and MT2A rs10636) SNPs, respectively, and rs8052394 was associated with both outcomes. The MT1A rs8052394 SNP may be used as a susceptibility biomarker to identify individuals at greater risk for higher Hg levels and the development of neurocognitive disorders in metal-exposed populations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview

Perini,

Cardoso,

Knesse

et al. 2024

Toxics

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“…There is one report of Cd exposure and OS in children, showing that both urinary and breast milk Cd concentrations were positively associated with urinary 8-oxodG in very young infants (Kippler et al 2012). On the other hand, in the general population of Brazilian adults, low-level blood Cd was not associated with levels of malondialdehyde (MDA), a marker of lipid peroxidation (Almeida Lopes et al 2017). On the other hand, a recent review showed inconsistent associations between Pb exposure and a number of OS biomarkers in children (Roy and Kordas 2015).…”

Section: Introductionmentioning

confidence: 99%

Multiple-metal exposure, diet, and oxidative stress in Uruguayan school children

Kordas

Roy

Vahter

et al. 2018

Environmental Research

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Oxidative stress (OS) is an important consequence of exposure to toxic metals but it is unclear to what extent low-level metal exposures contribute to OS in children. We examined the cross-sectional association between urinary concentrations of arsenic (As), cadmium (Cd), and lead (Pb) and urinary markers of OS: F-8α isoprostane and 8-hydroxy-2-deoxy-guanosine (8-OHdG). We also tested effect modification by dietary intakes. Of the 211 children aged 6-8 years living in Montevideo who were eligible for the study because they had at least one OS marker measured via ELISA, 143 were included in a complete-case analysis. Urinary metals were measured with inductively coupled plasma mass spectrometry (ICP-MS: Pb, Cd) and high-performance liquid chromatography online with hydride generation ICP-MS (As-metabolites); concentrations were log-transformed. All urinary markers were adjusted for specific gravity of urine. Two 24-h dietary recalls were conducted to estimate children's dietary intakes, including total fruit and vegetable consumption and vitamin C, zinc and fiber intake. Ordinary least square (OLS) and weighted quantile sum (WQS) regressions were used to estimate the association between metals and each OS marker as outcome. Metal exposure was generally low: median urinary As, Cd, Pb 9.6 μg/L, 0.06 μg/L and 1.9 μg/L, respectively. Median 8-isoprostane concentration was 1.1 and 8-OHdG 39.6 ng/mL. Log-transformed urinary As concentrations were positively associated with 8-OHdG concentrations (10.90 [3.82, 17.97]) in covariate-adjusted OLS models which also took account of exposure to Cd and Pb. In WQS, a mixture index was also associated with higher 8-OHdG (8.71 [1.12, 16.3] for each 25% increase in index value), mostly driven by As exposure. There was little evidence of effect modification by dietary antioxidants. In sum, even at low-level, As exposure is associated with detectable oxidative damage to the DNA.

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“…[20,21] Several studies linked exposure to Pb with increased levels of MDA. [22][23][24] Visfatin exhibits a significant presence in visceral adipose tissue, and there is a positive association between visfatin levels in the bloodstream and obesity. [25] Furthermore, visfatin is recognized as a nicotinamide phosphoribosyl transferase that plays a direct role in the production of nicotinamide adenine dinucleotide.…”

Section: Introductionmentioning

confidence: 99%

Biochemical study of the effect of lead exposure in nonobese gasoline station workers and risk of hyperglycemia: A retrospective case-control study

Numan,

Jawad,

Fawzi

2024

Medicine

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Evaluate the relationship between blood lead (Pb) levels and other biomedical markers and the risk of diabetes in gasoline station workers. The participants were separated into 2 groups: group A consisted of 26 workers from gasoline filling stations, while group B comprised 26 healthy individuals. Serum levels of malondialdehyde, IL-1β, visfatin, insulin, fasting blood sugar, and vitamin D were assessed. Mean Pb level was significantly higher in group A compared to group B (almost 2.9 times higher levels) (14.43 ± 1.01 vs 5.01 ± 1.41, µg/dL). The levels of visfatin (23.19 ± 0.96 vs 3.88 ± 0.58, ng/mL), insulin (22.14 ± 1.31 vs 11.26 ± 0.75, mU/L), fasting blood sugar (118.4 ± 26.1 vs 82.7 ± 9.2, gm/dL), malondialdehyde (6.40 ± 0.27 vs 1.62 ± 0.21, nmol/mL), and IL-1β (330.25 ± 10.34 vs 12.35 ± 1.43, pg/mL) were significantly higher in group A, meanwhile; vitamin D (11.99 ± 1.55 vs 35.41 ± 3.16, ng/mL) were significantly lower in group A. A positive association exists between blood Pb levels and increased inflammatory markers. Lead exposure increases serum insulin and fasting blood sugar, which suggests that it is diabetogenic and that increased inflammation is a possible cause.

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Association of lead, cadmium and mercury with paraoxonase 1 activity and malondialdehyde in a general population in Southern Brazil

Cited by 20 publications

References 54 publications

Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview

Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview

Multiple-metal exposure, diet, and oxidative stress in Uruguayan school children

Biochemical study of the effect of lead exposure in nonobese gasoline station workers and risk of hyperglycemia: A retrospective case-control study

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