Association of Left Atrial Stiffness With Risk of Cryptogenic Ischemic Stroke in Young Adults

Sindre, Rasmus Bach; Gerdts, Eva; Putaala, Jukka; Grymyr, Lisa M.D.; Midtbø, Helga; Almeida, Ana G.; Bech-Hanssen, Odd; Busch, Raila; Eilertsen, Rune K.; Fonseca, Ana Catarina; Hedman, Marja; Huhtakangas, Juha; Jäkälä, Pekka; Lautamäki, Riikka; Lehto, Mika; Martinez-Majander, Nicolas; Redfors, Petra; Sarkanen, Tomi; von Sarnowski, Bettina; Sinisalo, Juha; Virtanen, Marko; Waje-Andreassen, Ulrike; Yesilot, Nilufer; Ylikotila, Pauli; Cramariuc, Dana

doi:10.1016/j.jacadv.2024.100903

Cited by 1 publication

(1 citation statement)

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“…Recent analyses of first SECRETO including 150 patients and controls also demonstrated that left atrial myopathy more than doubled the risk of young-onset CIS, but LA myopathy was not associated with heavy alcohol consumption itself. 28 Heavy drinkers may also harbour several other risk factors making them as potentially important target group for both primary and secondary preventive measures.…”

Section: Cerebrovascular Diseasementioning

confidence: 99%

Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: a case–control study

Martinez-Majander,

Kutal,

Ylikotila

et al. 2024

J Neurol Neurosurg Psychiatry

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BackgroundThe underlying risk factors for young-onset cryptogenic ischaemic stroke (CIS) remain unclear. This multicentre study aimed to explore the association between heavy alcohol consumption and CIS with subgroup analyses stratified by sex and age.MethodsAltogether, 540 patients aged 18–49 years (median age 41; 47.2% women) with a recent CIS and 540 sex-matched and age-matched stroke-free controls were included. Heavy alcohol consumption was defined as >7 (women) and >14 (men) units per week or at least an average of two times per month ≥5 (women) and ≥7 (men) units per instance (binge drinking). A conditional logistic regression adjusting for age, sex, education, hypertension, cardiovascular diseases, diabetes, hypercholesterolaemia, current smoking, obesity, diet and physical inactivity was used to assess the independent association between alcohol consumption and CIS.ResultsPatients were twice as more often heavy alcohol users compared with controls (13.7% vs 6.7%, p<0.001), were more likely to have hypertension and they were more often current smokers, overweight and physically inactive. In the entire study population, heavy alcohol consumption was independently associated with CIS (adjusted OR 2.11; 95% CI 1.22 to 3.63). In sex-specific analysis, heavy alcohol consumption was associated with CIS in men (2.72; 95% CI 1.25 to 5.92), but not in women (1.56; 95% CI 0.71 to 3.41). When exploring the association with binge drinking alone, a significant association was shown in the entire cohort (2.43; 95% CI 1.31 to 4.53) and in men (3.36; 95% CI 1.44 to 7.84), but not in women.ConclusionsHeavy alcohol consumption, particularly binge drinking, appears to be an independent risk factor in young men with CIS.

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Section: Cerebrovascular Diseasementioning

confidence: 99%