Association of left ventricular hypertrophy and functional impairment with cardiovascular outcomes and mortality among patients with chronic kidney disease, results from the<scp>C‐STRIDE</scp>study

Wang, Jinwei; Lv, Jicheng; He, Kevin; Wang, Fang; Gao, Bixia; Zhao, Ming‐Hui; Zhang, Luxia

doi:10.1111/nep.14009

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…Cardiovascular events account for up to 43% of deaths in CKD patients, hence, the early intervention of LVH can effectively reverse LVH and improve the survival rate of CKD patients. 12 The results of our research may have been influenced by numerous variables, which include BMI, LDL, and 24 h-Upros.…”

Section: Discussionmentioning

confidence: 90%

Risk Factors for Left Ventricular Hypertrophy in Patients with Diabetic Kidney Disease: A Multi-Center Study

Wang¹,

Zhu²,

Peng³

et al. 2023

IJGM

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One of the earliest echocardiographic features of the left ventricle explored extensively was left ventricular hypertrophy (LVH). Numerous studies have identified a few risk factors for LVH, however, there are few for people with diabetic kidney disease (DKD). Therefore, we evaluated the risk factors in DKD patients with LVH by analyzing laboratory data and clinical traits. Methods: In total, 500 DKD patients in the Baoding area from February 2016 and June 2020 were admitted and classified as an experimental group (240 cases, LVH group) and a control group (260 cases, non-LVH group). The clinical parameters and laboratory tests of the participants were collected and analyzed retrospectively. Results: Compared with the control group, low-density lipoprotein (LDL), body mass index (BMI), intact parathyroid hormone (iPTH), systolic blood pressure, and 24-hour urine protein were higher in the experimental group (all P<0.01). Multivariable logistic regression analysis results confirmed that high BMI (OR=1.332, 95% CI 1.016-1.537, P=0.006), LDL (OR=1.279, 95% CI 1.008-1.369, P=0.014) and 24-hour urine proteins (OR=1.446, 95% CI 1.104-1.643, P=0.016) were statistically significant. The ROC analysis illustrated that the optimum cutoff value of BMI, LDL, and 24-hour urine proteins for diagnosis of LVH in patients with DKD was 27.36 kg/m 2 , 4.18 mmol/L, and 1.42 g respectively. Conclusion:The increase in BMI, LDL, and 24-hour urine proteins quantification are independent risk factors for LVH in patients with DKD.

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Section: Discussionmentioning

confidence: 90%

Risk Factors for Left Ventricular Hypertrophy in Patients with Diabetic Kidney Disease: A Multi-Center Study

Wang¹,

Zhu²,

Peng³

et al. 2023

IJGM

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“…Superimposition of hypertension and diabetes has been shown to induce accelerated nephropathy in mice [ 18 ], and concomitant presence of hypertension and diabetes in humans increases the chances of mice to develop chronic kidney disease [ 38 , 39 ]. In our study, HFD regimen resulted in protection against kidney injury and impairment in function (Figs 4 and 5 ).…”

Section: Discussionmentioning

confidence: 99%

“…Hyperglycemia alone can lead to diabetic nephropathy, a common cause of chronic kidney disease that could lead to end-stage renal disease [36]. Reversal of nephropathy in type-1 diabetes model is not easy achieved, even with tight control of glycemic levels [37] Superimposition of hypertension and diabetes has been shown to induce accelerated nephropathy in mice [18], and concomitant presence of hypertension and diabetes in humans increases the chances of mice to develop chronic kidney disease [38,39]. In our study, HFD regimen resulted in protection against kidney injury and impairment in function (Figs 4 and 5).…”

Section: Discussionmentioning

confidence: 99%

High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury

et al. 2023

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Chronic kidney disease (CKD) is a worldwide health burden with increases risk of end-stage renal function if left untreated. CKD induced in the context of metabolic syndrome (MS) increases risks of hypertension, hyperglycemia, excess body fat and dyslipidemia. To test if combining a high-fat diet (HFD) regimen onto the hypertensive/ diabetic phenotype would mimic features of MS induced-CKD in mice, hyperglycemia was induced in genetically hypertensive mice (Lin), followed by HFD regimen. For that, 8-week-old male were subjected to streptozotocin (STZ) intraperitoneal (i.p.) injections (50 mg/kg, 5 days consecutive). LinSTZ were fed a 60% kCal HFD for 8 weeks. Lin mice treated with STZ developed polydipsia, became hypertensive and hyperglycemic. HFD induced weight gain, protected against glomerular hypertrophy, scarring, and albuminuria at endpoint compared to regular diet fed LinSTZ. On the other hand, HFD induced steatosis, liver fibrosis, inflammation, and increase in AST/ALT ratio, characteristics of non-alcoholic liver disease. Taken together, our results show that LinSTZ mice fed a HFD did not lead to a more robust model of MS-induced CKD, protected against kidney injury, but inducing liver damage. More studies are necessary to understand the kidney protective mechanisms of HFD when superimposed with hypertension and type 1 diabetes.

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“…Furthermore, the lower the eGFR, the higher the risk of in-hospital mortality and MACE in CKD patients with ACS. [125] Echocardiographic Parameters and Cardiovascular Outcomes and Mortality among Patients with CKD A total of 2020 patients with CKD stages 1-4 from Chinese Cohort Study of CKD (CSTRIDE) were enrolled to evaluate the relationship between left ventricular hypertrophy and impaired systolic and diastolic function and cardiovascular outcomes. Left ventricular hypertrophy was defined by left ventricular mass index > 49.2 g/m 2.7 in men and > 46.7 g/m 2.7 in women.…”

Section: Prevalencementioning

confidence: 99%

Cardiovascular Risk Factors in China

2024

Journal of Geriatric Cardiology

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The Annual Report on Cardiovascular Health and Diseases in China (2022) intricate landscape of cardiovascular health in China. This section dissects cardiovascular risk factors in China which including hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease, metabolic syndrome and air pollution. Hypertension prevalence has steadily increased in China, with efforts to control it facing challenges in achieving optimal rates, especially in rural areas. Interventions like salt substitutes and intensive blood pressure control show promise but need improvement. Abnormal lipid levels, indicative of dyslipidemia, have risen significantly, posing a risk for cardiovascular diseases. Despite efforts, many patients struggle to achieve target lipid levels, necessitating improved treatment strategies. Both type 1 and type 2 diabetes mellitus affect millions of adults in China, with long-term complications adding to the disease burden. Early intervention and effective management are crucial to mitigate its impact. Prevalent among older adults, chronic kidney disease is associated with diabetes mellitus, hypertension, and cardiovascular diseases, necessitating comprehensive management approaches. The prevalence of metabolic syndrome, characterized by a cluster of risk factors, has increased in both adults and adolescents, calling for lifestyle modifications and public health interventions. Ambient and household air pollution remain significant environmental risk factors, despite some improvements in air quality. Continued efforts to reduce emissions are essential for mitigating associated health risks. Addressing these risk factors requires a multifaceted approach, including public health initiatives, policy interventions, and individual-level strategies to promote healthy lifestyles and reduce environmental exposures. Surveillance and research efforts are crucial for monitoring trends and developing effective strategies to lessen the burden of cardiovascular diseases in China.CARDIOVASCULAR

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Association of left ventricular hypertrophy and functional impairment with cardiovascular outcomes and mortality among patients with chronic kidney disease, results from theC‐STRIDEstudy

Cited by 4 publications

References 37 publications

Risk Factors for Left Ventricular Hypertrophy in Patients with Diabetic Kidney Disease: A Multi-Center Study

Risk Factors for Left Ventricular Hypertrophy in Patients with Diabetic Kidney Disease: A Multi-Center Study

High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury

Cardiovascular Risk Factors in China

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