Association of leukocyte telomere attrition in coronary artery disease in Pakistani population: A case-control study with meta-analysis

Rafiq, Muhammad; Liaquat, Afrose; Javed, Arham; Shah, Saeed Ullah; Hussain, Rashid; Akram, Zaineb; Khan, Muhammad Jadoon

doi:10.1016/j.cca.2023.117416

Clinica Chimica Acta

2023

DOI: 10.1016/j.cca.2023.117416

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Association of leukocyte telomere attrition in coronary artery disease in Pakistani population: A case-control study with meta-analysis

Muhammad Rafiq

Afrose Liaquat

Arham Javed

et al.

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Cited by 3 publications

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Association Between TTV Viremia, Chronic Inflammation, and Ischemic Heart Disease Risk: Insights From MARK-AGE and Report-Age Projects

Giacconi,

Piacenza,

Maggi

et al. 2024

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

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The implication of Torquetenovirus (TTV) in Ischemic Heart Disease (IHD) has not been thoroughly explored. This study investigated the association between TTV viremia, proinflammatory cytokines, and IHD risk in an aging population. This cross-sectional study included 900 non-IHD subjects (NIHD) and 86 individuals with IHD (aged 55 to 75 years) selected from the MARK-AGE project. Results were verified in another independent Report-Age cohort, including 94 inpatients with chronic IHD and 111 inpatients with no evidence of IHD (NIHD) (aged 65 to 96 years). Multivariable logistic regression in the MARK-AGE cohort revealed that male sex, TTV viremia ≥4log, Cu/Zn ratio, diabetes, hypertension and smoking were significant IHD predictors. Notably, TTV viremia ≥4log independently increased the IHD risk (OR: 2.51, 95% CI: 1.42-4.43), confirmed in the Report-Age cohort (OR: 4.90, 95% CI: 2.32-10.39). In a RASIG subgroup, individuals with TTV viremia ≥4log, both with and without IHD, exhibited increased plasma pro-inflammatory cytokine levels (IFN-γ, IL-1β, IL-6, IL-10, IL-12p70, TNF-α) compared to those with TTV viremia < 4log. No significant difference in cytokine production was observed between IHD patients and NIHD with TTV viremia ≥4log. A positive correlation between TTV viremia and DNA methylation estimator of leukocyte telomere length was observed in Report-Age patients. Additionally, IHD Report-Age patients with TTV viremia ≥4log displayed higher NLR and SIRI index than those with TTV viremia < 4log. In conclusion, a high TTV viremia is associated with an elevated IHD risk in the older population, potentially arising from an augmented proinflammatory response and immunosenescence

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Association Between TTV Viremia, Chronic Inflammation, and Ischemic Heart Disease Risk: Insights From MARK-AGE and Report-Age Projects

Giacconi,

Piacenza,

Maggi

et al. 2024

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

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Assessment of the relationship between telomere length and atherosclerosis: A Mendelian randomization study

Li,

Liu,

Chen

et al. 2023

Medicine

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To evaluate the causal relationship between genetically determined telomere length (TL) and atherosclerosis (AS). We performed a 2-sample Mendelian randomization (MR) study to assess the potential causal relationship between TL and AS (coronary AS, cerebral AS, peripheral atherosclerosis (PAD), and AS, excluding cerebral, coronary, and PAD). The TL phenotype contained 472,174 participants, and the 4 subtypes of AS had 361,194, 218,792, 168,832, and 213,140 participants, all of European ancestries. The single nucleotide polymorphisms (SNPs) of TL strongly associated with the 4 atherosclerotic subtypes included in this study were 101, 92, 91, and 92, respectively. The odds ratios (ORs) and 95% confidence interval (CI) between TL and coronary AS calculated using inverse variance weighted (IVW) were 0.993 (0.988, 0.997), and the results were statistically significant (P < .05). The results between TL and cerebral AS, PAD, and AS (excluding cerebral, coronary, and PAD) were not statistically significant (P > .05). “Egger-intercept test” showed that there was no horizontal pleiotropy (P > .05); “leave-one-out analysis” sensitivity analysis showed that the results were stable and there were no instrumental variables with strong effects on the results; “MR- pleiotropy residual sum and outlier (PRESSO) test” showed 1 outlier for coronary AS and no outliers for the remaining subgroups. The results of the 2-sample MR analysis showed a causal association between TL and coronary AS but not with cerebral AS, PAD, and AS (excluding cerebral, coronary, and PAD). This may elucidate the observation that various vascular regions can be affected by AS but highlights the propensity of coronary arteries to be more susceptible to AS development.

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White blood cell counts can predict 4-year cardiovascular disease risk in patients with stable coronary heart disease: a prospective cohort study

Jiang,

Huang,

et al. 2024

Front. Cardiovasc. Med.

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BackgroundThe prevalence of cardiovascular disease has increased sharply in the Asian population, and evaluation of the risk of cardiovascular events with stable coronary heart disease remains challenging. The role of white blood cell (WBC) count in assisting clinical decision-making in this setting is still unclear.ObjectivesThis study sought to evaluate the prognostic meaning of WBC count among patients with stable coronary heart disease.MethodsThis study included Asian participants (n = 1,933) from the prospective STABILITY (Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy) trial, which involved 15,828 patients with stable coronary heart disease with 3–5 years of follow-up on optimal secondary preventive treatment. WBC count was measured at baseline. Associations between WBC count and cardiovascular outcomes were evaluated by Cox regression analyses with multivariable adjustments. Hematologic emergencies in patients may introduce potential bias.ResultsIn the lower WBC count quartiles, patients had lower-risk clinical profiles. Higher WBC counts were associated with greater event probabilities for cardiovascular death, major cardiovascular events, or all-cause death. In Cox regression models, WBC counts were an independent predictor of major adverse cardiovascular events (OR = 2.445, 95% CI 1.427–4.190, P = 0.001) for the primary outcomes. For the secondary outcomes, including the composite of all-cause death, cardiovascular death, myocardial infarction, stroke, and hospitalization for heart failure, WBC counts were significantly predictive of events with similar magnitude (OR = 1.716, 95% CI 1.169–2.521, P = 0.006).ConclusionsIn patients with stable coronary heart disease, higher WBC counts were associated with a heightened risk for the primary or secondary outcomes. Registrationhttps://clinicaltrials.gov/; Unique identifier NCT00799903.

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Association of leukocyte telomere attrition in coronary artery disease in Pakistani population: A case-control study with meta-analysis

Cited by 3 publications

References 52 publications

Association Between TTV Viremia, Chronic Inflammation, and Ischemic Heart Disease Risk: Insights From MARK-AGE and Report-Age Projects

Association Between TTV Viremia, Chronic Inflammation, and Ischemic Heart Disease Risk: Insights From MARK-AGE and Report-Age Projects

Assessment of the relationship between telomere length and atherosclerosis: A Mendelian randomization study

White blood cell counts can predict 4-year cardiovascular disease risk in patients with stable coronary heart disease: a prospective cohort study

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