Association of lipid accumulation product with type 2 diabetes mellitus, hypertension, and mortality: a systematic review and meta-analysis

Khanmohammadi, Shaghayegh; Tavolinejad, Hamed; Aminorroaya, Arya; Rezaie, Yasaman; Ashraf, Haleh; Vasheghani‐Farahani, Ali

doi:10.1007/s40200-022-01114-z

Cited by 17 publications

(17 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, a large cross-sectional study of 215,651 Chinese adults by Tian et al reported that the prevalence of diabetes was significantly higher in the fourth quartile of LAP (21.76%) compared to the first quartile of LAP (5.72%) [ 21 ]. These findings are supported by a systematic review and meta-analysis of 18 studies by Khanmohammadi et al, which concluded that there is a strong association between LAP and T2DM [ 29 ]. Consistent with previous studies, we found that patients in the fourth quartile of LAP had a 16.196-fold higher risk of early-onset T2DM than those in the first quartile, with control subjects as reference.…”

Section: Discussionmentioning

confidence: 54%

“…Additionally, the Tehran lipid and glucose study [ 30 ] showed that LAP was a stronger predictor of diabetes than BMI. A systematic review by Khanmohammadi et al [ 29 ] found that most studies showed that LAP was more effective in predicting T2DM than traditional indices, including BMI and WC. Several studies [ 35 , 38 , 41 , 42 ] have demonstrated that VAI outperformed conventional indices (BMI, WC) in the discrimination of diabetes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of lipid accumulation product and visceral adiposity index with traditional obesity indices in early-onset type 2 diabetes prediction: a cross-sectional study

Lin

et al. 2023

Diabetol Metab Syndr

View full text Add to dashboard Cite

Background The purpose of the study was to compare the efficacy of two novel obesity indices, lipid accumulation product (LAP) and visceral adiposity index (VAI), with traditional obesity indices in predicting early-onset type 2 diabetes (T2DM). Methods In this cross-sectional study, a total of 744 participants, including 605 patients newly diagnosed with T2DM and 139 non-diabetic control subjects, were enrolled from a tertiary care hospital in Tianjin, China. Participants with T2DM were divided into two groups based on their age at diagnosis, namely early-onset T2DM (age less than 40 years, n = 154) and late-onset T2DM (age 40 years or older, n = 451). The predictive power of each obesity index was evaluated using receiver operating characteristic (ROC) curve analysis. Furthermore, binary logistic regression analysis was conducted to examine the independent relationship between LAP and VAI with early-onset T2DM risk. The relationship between novel obesity indices and the age of T2DM onset was also evaluated through correlation and multiple linear regression analysis. Results In males, LAP had the highest predictive power for early-onset T2DM with an area under the ROC curve (AUC) of 0.742 (95% CI 0.684–0.799, P < 0.001). In females, VAI had the highest AUC for early-onset T2DM with a value of 0.748 (95% CI 0.657–0.839, P < 0.001), which was superior to traditional indices. Patients in the 4th quartile of LAP and VAI had 2.257 (95% CI 1.116–4.563, P = 0.023) and 4.705 (95% CI 2.132–10.384, P < 0.001) times higher risk of T2DM before age 40, compared to those in the 1st quartile, respectively. A tenfold increase in LAP was associated with a decrease in T2DM onset age of 12.862 years in males (β = −12.862, P < 0.001) and 6.507 years in females (β = −6.507, P = 0.013). A similar decrease in T2DM onset age was observed for each tenfold increase in VAI in both male (β = −15.222, P < 0.001) and female (β = −12.511, P < 0.001) participants. Conclusions In young Chinese individuals, LAP and VAI are recommended over traditional obesity indices for improved prediction of early-onset T2DM risk.

show abstract

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Comparison of lipid accumulation product and visceral adiposity index with traditional obesity indices in early-onset type 2 diabetes prediction: a cross-sectional study

Lin

et al. 2023

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…LAP has emerged as a promising anthropometric index for assessing cardiometabolic risk ( 31 , 34 ). Evidence showed that LAP serves as a predictor of diabetes risk in both Japanese and Chinese populations, outperforming traditional obesity indicators ( 35 , 36 ).…”

Section: Discussionmentioning

confidence: 99%

Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study

Dong,

Lin,

Zhou

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundCardiometabolic multimorbidity (CMM) has emerged as a prominent public health concern. Hypertensive patients are prone to develop comorbidities. Moreover, the accumulation of visceral adipose tissue is the main cause for the development of cardiometabolic diseases. The cardiometabolic index (CMI), lipid accumulation product (LAP), visceral adiposity index (VAI), and Chinese visceral adiposity index (CVAI) not only assess adipose tissue mass but also reflect adipose tissue dysfunction. So far, no study has been reported to evaluate the association of CMI, LAP, VAI, and CVAI with CMM risk in hypertensive patients. Therefore, this study aimed to assess the association between these adiposity indicators and the risk of CMM among Chinese hypertensive patients.MethodsIn this cross-sectional study, a total of 229,287 hypertensive patients aged 35 years and older were included from the National Basic Public Health Service Project. All participants underwent a face-to-face questionnaire survey, physical examination, and the collection of fasting venous blood samples. Multivariable logistic regression models were performed to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Receiver operating characteristic curve was utilized to evaluate the identification ability for CMM.ResultsAfter adjusting for confounders, each 1-standard deviation increase in CMI, LAP, VAI, and CVAI was associated with a 14%, 8%, 12%, and 54% increased risk of CMM, respectively. When comparing the highest quartile of these indicators with the lowest quartile, individuals in the highest quartile of CMM, LAP, VAI, and CVAI had a 1.39-fold (95% CI 1.30, 1.48), 1.28-fold (95% CI 1.19, 1.37), 1.37-fold (95% CI 1.29, 1.46), and 2.56-fold (95% CI 2.34, 2.79) increased risk of CMM after adjusting for potential confounders. Notably, a nonlinear association was observed for CMI, LAP, and VAI with the risk of CMM (all P nonlinearity < 0.001). CVAI exhibited the highest area under the receiver operating characteristic curve (AUC) among all the included adiposity indices in this analysis.ConclusionThis study indicated the significant positive association of CMI, LAP, VAI, and CVAI with the risk of CMM in hypertensive patients. Among these indicators, CVAI demonstrated the most robust performance in predicting CMM risk and may serve as a valuable tool for identifying CMM risk in Chinese hypertensive patients.

show abstract

“…A systematic review and meta-analysis showed that, LAP is an inexpensive method to evaluate the risk of all-cause mortality, and hypertension. Also, it is an accurate indicator for diagnosing and evaluating diabetes, which can perform better than anthropometric indicators in this field 12 . Furthermore, another systematic review study reported a strong association between diabetes risk and LAP 13 .…”

Section: Introductionmentioning

confidence: 99%

The association between dietary diabetic risk reduction score with anthropometric and body composition variables in overweight and obese women: a cross-sectional study

Karimi

Shiraseb

Mofìdi

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Dietary diabetes risk reduction score (DDRRs) is inversely associated with a lower risk of type 2 diabetes. Given the importance of the association between body fat and insulin resistance and the effect of diet on these parameters, this study aimed to investigate the association between DDRRS and body composition parameters, including the visceral adiposity index (VAI), lipid accumulation product (LAP), and skeletal muscle mass (SMM). This study was conducted on 291 overweight and obese women aged 18–48 years old recruited from 20 Tehran Health Centers in 2018. The anthropometric indices, biochemical parameters, and body composition were measured. A semi-quantitative food frequency questionnaire (FFQ) was used to calculate DDRRs. Linear regression analysis was used to examine the association between DDRRs and body composition indicators. The mean (SD) age of participants was 36.67 (9.10) years. After adjustment for potential confounders, VAI (β = 0.27, 95% CI = − 0.73, 1.27, Ptrend = 0.052), LAP (β = 8.14, 95% CI = − 10.54, 26.82, Ptrend = 0.069), TF (β = − 1.41, 95% CI = 11.45, 17.30, Ptrend = 0.027), trunk fat percent (TF%) (β = − 21.55, 95% CI = − 44.51, 1.61, Ptrend = 0.074), body fat mass (BFM) (β = − 3.26, 95% CI = − 6.08, − 0.44, Ptrend = 0.026), visceral fat area (VFA) (β = − 45.75, 95% CI = − 86.10, − 5.41, Ptrend = 0.026), waist-to-hip ratio (WHtR) (β = − 0.014, 95% CI = − 0.031, 0.004, Ptrend = 0.066), visceral fat level (VFL) (β = − 0.38, 95% CI = − 5.89, 5.12, Ptrend = 0.064), fat mass index (FMI) (β = − 1.15, 95% CI = − 2.28, − 0.02, Ptrend = 0.048) decreased significantly over tertiles of DDRRs, and also there was no significant association between SMM and DDRRs tertiles (β = − 0.57, 95% CI = − 1.69, 0.53, Ptrend = 0.322). The findings of this study demonstrated that participants with higher adherence to the DDRRs had lower VAI (β = 0.78 vs 0.27) and LAP (β = 20.73 vs 8.14). However, there was no significant association between DDRRs and VAI, LAP and SMM, which are mentioned as the primary outcomes. Future studies with larger sample of both genders are needed to investigate our findings.

show abstract

Association of lipid accumulation product with type 2 diabetes mellitus, hypertension, and mortality: a systematic review and meta-analysis

Cited by 17 publications

References 50 publications

Comparison of lipid accumulation product and visceral adiposity index with traditional obesity indices in early-onset type 2 diabetes prediction: a cross-sectional study

Comparison of lipid accumulation product and visceral adiposity index with traditional obesity indices in early-onset type 2 diabetes prediction: a cross-sectional study

Association of adiposity indicators with cardiometabolic multimorbidity risk in hypertensive patients: a large cross-sectional study

The association between dietary diabetic risk reduction score with anthropometric and body composition variables in overweight and obese women: a cross-sectional study

Contact Info

Product

Resources

About