Association of Lipid Profile and Uric Acid with Pre-Eclampsia of Third Trimester in Nullipara Women

Agarwal, Vibhuti; Gupta, Bharat; Vishnu, Abhishek; Mamtatyagi,; Shiprasolanki,; Kiran, Jas

doi:10.7860/jcdr/2014/7901.4533

Cited by 13 publications

(10 citation statements)

References 25 publications

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“…However, in preeclampsia, there is dysregulation of lipid metabolism, which manifests as abnormal maternal serum lipid levels [32][33][34]. Consistent with this study, several other studies have reported dyslipidaemia in preeclampsia and stated that abnormal lipid levels in pregnancy signi cantly contribute to the development of preeclampsia through the excessive deposition of triglycerides in the uterine spiral arteries which may result in endothelial dysfunction through the production of small dense LDL [32][33][34][35][36]. Although the women with preeclampsia in this study presented with abnormal serum lipid, no signi cant association between vitamin D de ciency and lipid was observed in both the normotensive women and preeclamptic women after adjusting for possible confounders.…”

Section: Discussionsupporting

confidence: 78%

High Prevalence of Vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

Fondjo

Tashie

Owiredu

et al. 2021

Preprint

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Background: Hypovitaminosis D in pregnancy is associated with adverse health outcomes in mothers, newborns and infants. This study assessed the levels of 25-hydroxyvitamin D [25(OH)D] in normotensive pregnancies and pregnancies complicated by preeclampsia, and evaluated the association between vitamin D deficiency and foeto-maternal outcome. Methods: This case-control study was conducted among pregnant women who visited the Comboni Hospital, in Ghana from January 2017 to May 2018 for antenatal care. A total of 180 pregnant women comprising 88 preeclamptic women (PE) and 92 healthy normotensive pregnant women (NP) were recruited. Socio-demographic, clinical and obstetric data were obtained using validated questionnaires. Blood pressure and anthropometrics were measured, and blood samples were collected for the estimation of 25(OH)D using enzyme-linked immunosorbent assay technique. Lipids (total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol) and were also estimated. Results: A total of 81.7% of the study participants had vitamin D deficiency. Of these, 88.6% of the women with PE had vitamin D deficiency compared to 75.0% in the NP. Vitamin D levels was significantly reduced in the PE women compared to the normotensive pregnant women (p=0.001). A higher proportion of the preeclamptic women who were vitamin D deficient had preterm delivery (p < 0:0001) and delivered low birth weight infants (p < 0:0001), and infants with IUGR (p < 0:0001) compared to the control group (p < 0:0001). Pregnant women with PE presented with significant dyslipidaemia, evidenced by significantly elevated TC (p=0.008), LDL (p<0.0001), triglycerides (p=0.017) and a significantly reduced HDL (p=0.001) as compared to NP. In the preeclamptic women, serum 25(OH)D showed an inverse, but not significant association with TC (β= -0.087, p=0.464), TG (β= -0.143, p=0.233) and LDL (β= -0.101, p=0.388) and a positive, but not significant association with HDL (β= 0.166, p=0.154). Conclusion: The prevalence of vitamin D deficiency is high in both normotensive pregnancies and pregnancies complicated by preeclampsia but amplified in preeclampsia. Higher proportion of pregnant women with hypovitaminosis D had preterm babies and delivered low birth weight neonates. Additional studies are needed to explore the potential benefits and optimal dosing of vitamin D use in pregnancy especially in sub-Saharan Africa.

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Section: Discussionsupporting

confidence: 78%

High Prevalence of Vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

Fondjo

Tashie

Owiredu

et al. 2021

Preprint

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“…*P < .05, significant; **P < .01, very significant, compared with the control group severity of HDCP and assist in further studying the cause and pathophysiology of HDCP. Our findings are consistent with previous studies,15,[17][18][19] which implicated metabolic and inflammatory changes involved in the pathogenesis of preeclampsia. However, previous studies mostly recruited patients with MPE or SPE.…”

supporting

confidence: 94%

“…Differential expressed lipid profile and cytokines were found to gradually increase or decrease according to the severity of HDCP, which suggests that lipid profile and cytokines could predict the severity of HDCP and assist in further studying the cause and pathophysiology of HDCP. Our findings are consistent with previous studies, which implicated metabolic and inflammatory changes involved in the pathogenesis of preeclampsia. However, previous studies mostly recruited patients with MPE or SPE.…”

Section: Discussionmentioning

confidence: 99%

Lipid profile and cytokines in hypertension of pregnancy: A comparison of preeclampsia therapies

Wang

Shi

Chen

2018

J of Clinical Hypertension

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Hypertensive disorders complicating pregnancy can be classified as gestational hypertension, mild preeclampsia, and severe preeclampsia. It is necessary to evaluate and predict the grade in advance. The first study comprised 40 healthy pregnancies, 40 gestational hypertension, 40 mild preeclampsia, and 40 severe preeclampsia cases.The participants' lipid profile and cytokine levels were statistically compared. The efficacy and safety of oral nifedipine (n = 71) and intravenous labetalol (n = 72) for the treatment of severe preeclampsia were evaluated in the next study according to maternal and neonatal outcomes. The levels of lipid profile and cytokines were linked with the presence and severity of hypertensive disorders complicating pregnancy.Both oral nifedipine and intravenous labetalol are effective for safely reducing blood pressure to target levels in patients with severe preeclampsia. Our study suggests that lipid profile and cytokines can be used in the evaluation of the severity of hypertensive disorders complicating pregnancy, and oral nifedipine requires more study.

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“…Different studies have tried to elucidate the association between the maternal serum lipid profiles and pre-eclampsia, but many of them have reported conflicting results. Some studies have shown higher levels of lipid profiles in pre-eclamptic women as compared to normotensive pregnant women [ 9 , 11 – 13 ]. However, a few studies have found non-significant difference in the serum levels of maternal lipid profiles between pre-eclamptic and normotensive pregnant women [ 14 , 15 ] and few other reports indicated lower serum lipid profiles in pre-eclamptic women as compared to normotensive controls.…”

Section: Introductionmentioning

confidence: 99%

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

2020

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Introduction Some studies have reported the association between maternal serum lipid profile abnormalities and pre-eclampsia. However, many studies have reported controversial results. Hence, this systematic review and meta-analysis was planned to generate summarized evidence on the association between maternal serum lipid profiles and pre-eclampsia in African women. Methods Four electronic databases such as; PubMed, Hinari, Google Scholar, and African Journals Online were searched for studies published in English. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument and Newcastle-Ottawa Scale were used for data extraction and quality assessment of the included studies. The meta- regression analysis was performed by Stata 14 software. The standardized mean difference (SMD) values of lipid profiles were computed to assess their association with pre-eclampsia at 95% CI. Results In this review a total of 15 observational studies were included. The mean values of triglyceride (TG), total cholesterol (TC), low density lipoprotein- cholesterol (LDL-c) and very low density lipoprotein- cholesterol (VLDL-c) were significantly higher in pre-eclamptic women as compared with normotensive pregnant women (TG = 229.61±88.27 and 147.00 ± 40.47, TC = 221.46 ± 45.90 and 189.67 ± 39.18, LDL = 133.92 ± 38.77 and 112.41 ± 36.08, VLDL = 41.44 ± 19.68 and 26.64 ± 7.87), respectively. The serum high density lipoprotein cholesterol (HDL-c) level was lower, but it is not statistically significant (HDL-c = 51.02 ± 16.01 and 61.80 ± 25.63) in pre-eclamptic women as compared with controls. The pooled standardized mean difference (SMD) of TG, TC, LDL-C and VLDL-C were significantly increased in pre-eclamptic women as compared with normotensive pregnant women with the SMD of (TG = 1.65 (1.10, 2.21), TC = 0.84 (0.40, 1.29), LDL-C = 0.95 (0.46, 1.45) and VLDL-C = 1.27 (0.72, 1.81)) at 95% CI, respectively, but the pooled SMD of HDL-cholesterol was decreased in pre-eclamptic women as compared with normotensive pregnant women (SMD = -0.91 (95% CI: -1.43, -0.39). Conclusions In this review, the maternal serum levels of TG, TC, LDL-c and VLDL-c were significantly associated with the risk of preeclampsia. However, HDL- cholesterol was not significantly associated but it was lower in pre-eclamptic women. Further, large scale prospective studies should verify these outcomes and it is recommended that lipid profiles should be included as a routine diagnostic test for pre-eclamptic women.

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Association of Lipid Profile and Uric Acid with Pre-Eclampsia of Third Trimester in Nullipara Women

Cited by 13 publications

References 25 publications

High Prevalence of Vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

High Prevalence of Vitamin D deficiency among normotensive and hypertensive pregnant women in Ghana

Lipid profile and cytokines in hypertension of pregnancy: A comparison of preeclampsia therapies

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

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