Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes

Izar, Maria Cristina de Oliveira; Helfenstein, Tatiana; Ihara, Sílvia Saiuli Miki; Relvas, W.G.M.; Santos, Ana Beatriz; Fischer, Sven; Pinto, Leonor do Espírito Santo de Almeida; Lopes, I.; Pomaro, Daniel Roberto; Fonseca, Miriam M.; Bodanese, Luis Carlos; Moriguchi, Emílio Hideyuki; Saraiva, José Francisco Kerr; Introcaso, Luiz; Souza, Agnaldo D. de; Scartezini, Mariléia; Torres, Kerginaldo Paulo; Zagury, Leão; Jardim, Paulo César Brandão Veiga; Costa, Eduardo A.; Tácito, Lúcia Helena Bonalume; Forti, Adriana Costa e; Magalhães, Maria Eliane Campos; Chacra, Antônio Roberto; Bertolami, Marcelo Chiara; Loures-Vale, Andréia Assis; Barros, Marco A.; Xavier, Hermes Tóros; Lyra, Rüy; Argamanijan, Dikran; Guimarães, Armênio Costa; Novazzi, José Paulo; Kasinski, Nelson; Afiune, Abrahão; Martinez, T.L.R.; Santos, Raul D.; Nicolau, José Carlos; Cesar, Luiz Antônio Machado; Póvoa, Rui Manuel dos Santos; Carvalho, Antônio Carlos Camargo; Han, Sang Won; Fonseca, Francisco A.

doi:10.1016/j.atherosclerosis.2008.08.006

Cited by 19 publications

(18 citation statements)

References 25 publications

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“…A novel P143L SNP with a frequency of about 6% was identified in a Chinese patients with coronary artery disease and was found to be linked with low HDL-C[106]. In contrast, a study of type 2 diabetes found no association between CHD and two other LCAT variants, Arg147Trp and Tyr171Stop[107]. Another LCAT variant, rs2292318, which was initially associated with lower HDL-C in a patient population with CHD, could not be subsequently validated in an independent population sample[108].…”

Section: Lcat and Cardiovascular Diseasementioning

confidence: 99%

Lecithin: cholesterol acyltransferase – from biochemistry to role in cardiovascular disease

Rousset

Vaisman²,

Amar³

et al. 2009

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

172

136

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Purpose of review We discuss the latest findings on the biochemistry of lecithin:cholesterol acyltransferase (LCAT), the effect of LCAT on atherosclerosis, clinical features of LCAT deficiency, and the impact of LCAT on cardiovascular disease from human studies. Recent findings Although there has been much recent progress in the biochemistry of LCAT and its effect on HDL metabolism, its role in the pathogenesis of atherosclerosis is still not fully understood. Studies from various animal models have revealed a complex interaction between LCAT and atherosclerosis that may be modified by diet and by other proteins that modify lipoproteins. Furthermore, the ability of LCAT to lower apoB appears to be the best way to predict its effect on atherosclerosis in animal models. Recent studies on patients with LCAT deficiency have shown a modest but significant increase incidence of cardiovascular disease consistent with a beneficial effect of LCAT on atherosclerosis. The role of LCAT in the general population, however, have not revealed a consistent association with cardiovascular disease. Summary Recent research findings from animal and humans studies have revealed a potential beneficial role of LCAT in reducing atherosclerosis but additional studies are necessary to better establish the linkage between LCAT and cardiovascular disease.

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Section: Lcat and Cardiovascular Diseasementioning

confidence: 99%

Lecithin: cholesterol acyltransferase – from biochemistry to role in cardiovascular disease

Rousset

Vaisman²,

Amar³

et al. 2009

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

172

136

View full text Add to dashboard Cite

show abstract

“…2 Usually, one of the practical attempts is to identify the hypertension-susceptibility genes that entails a specific physiological or biological function. 3 The lipoprotein lipase (LPL) gene is a logical candidate that has been extensively investigated in association with a series of clinical end points including, for example, myocardial infarction, 4,5 ischaemic stroke, 6 hypertriglyceridaemia, 7 diabetic nephropathy, 8 hypertension 9,10 and so on. In particular, a non-synonymous mutation in exon 9 of LPL gene, Ser447Ter (S447X), attracts special interest mainly considering its biological peculiarity because this biallelic change results in a truncated protein lacking two amino acids (Ser-Gly) at the carboxy terminus, 11 and usually the corresponding protein product is non-functional.…”

Section: Introductionmentioning

confidence: 99%

Meta-based association of the lipoprotein lipase gene S447X variant with hypertension and blood pressure variation

2010

J Hum Hypertens

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Association of the lipoprotein lipase (LPL) gene S447X variant with hypertension has been investigated extensively, whereas the results are often irreproducible. We therefore conducted a meta-analysis to examine whether S447X variant was associated with hypertension and blood pressure variation. Case-control reports published in English language and humans were identified from MEDLINE, EMBASE and Web of Science search engines as of 10 December 2009. Fixed-effects model was applied to pool data in the absence of between-studies heterogeneity, and random-effects model otherwise. A total of five studies (960 cases and 1145 controls) for hypertension and four studies (n=2777) for blood pressure were included. Compared with 447SS homogeneous carriers, those with 447X variant had a lower risk of hypertension (odds ratio (OR)=0.78; 95% confidence interval (CI): 0.62-0.98; P=0.03), and this effect reached significance under the fixed-effects model (I(2)=30% and P=0.22). Similarly, compared with 447S allele carriers, those with 447X allele carriers also had a lower risk of hypertension (OR=0.79; 95% CI: 0.64-0.98; P=0.03). In case of pregnancy-induced hypertension, no significance was observed (P>0.05). As for blood pressure association, there was no significant difference between 447X variant and 447SS homogeneous carriers for both systolic and diastolic blood pressure in the whole population, even stratified by gender (P>0.05). The Egger test told no publication bias for all associations. This meta-analysis demonstrated that LPL gene S447X variant was significantly associated with hypertension and showed no obvious relation with pregnancy-induced hypertension and blood pressure variation.

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“…If this were the case, it would be very difficult to replicate the LPL association with ischemic CVD between subpopulations. A recent study has found that a non-synonymous SNP in the LPL gene is strongly associated with myocardial infarction in patients with type 2 diabetes [12]. This finding is further evidence in support of the hypothesis that the interaction between the LPL polymorphism and diabetes may play an important role in determining the risk of atherothrombotic events.…”

Section: Discussionmentioning

confidence: 77%

Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke

Yang

Gao

et al. 2010

Transl. Stroke Res.

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The present study aimed to investigate the interaction between the Ser447Term polymorphism in the lipoprotein lipase (LPL) gene and some common risk factors for stroke. A total of 704 unrelated patients with ischemic stroke were recruited for genetic analysis; they were all of Han Chinese origin. These patients were classified into subgroups based on their exposure to stroke-related risk factors, including type 2 diabetes, hypertension, smoking, and hyperlipidemia. The Ser447Term polymorphism was genotyped by PCR-based restriction fragment length polymorphism analysis. The chi-square (χ (2)) test showed that the frequency of Ser447Term G allele was significantly higher in stroke patients with a history of diabetes than in those without a history of diabetes (χ (2) = 7.25, P = 0.007, OR = 1.78, 95%CI 1.18-2.68). Allelic association was not observed in patients exposed to the other three stroke-related risk factors. The combined effect of the LPL gene polymorphisms and diabetes may contribute to the development of a subgroup of ischemic stroke.

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Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes

Cited by 19 publications

References 25 publications

Lecithin: cholesterol acyltransferase – from biochemistry to role in cardiovascular disease

Lecithin: cholesterol acyltransferase – from biochemistry to role in cardiovascular disease

Meta-based association of the lipoprotein lipase gene S447X variant with hypertension and blood pressure variation

Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke

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