Association of Localized Intravascular Coagulopathy With Venous Malformations

Dompmartin, Anne; Acher, Aurélie; Thibon, Pascal; Tourbach, Sébastien; Hermans, Cédric; Deneys, Véronique; Pocock, Ben; Lequerrec, A.; Labbé, D.; Barrellier, M.-T.; Vanwijck, Romain; Vikkula, Miikka; Boon, Laurence M.

doi:10.1001/archderm.144.7.873

Cited by 294 publications

(279 citation statements)

References 19 publications

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“…However, a few patients are at risk of potential aggravation of LIC to DIC with dramatic bleeding during a surgical excision, and marked consumption of platelets, coagulation factors, and fibrinogen. 4 Therefore, measurement of D-dimer levels is mandatory in the management of VMs. 13 Venous malformation is not the only disease that can increase D-dimer levels highly and persistently in otherwise healthy patients, other conditions like glomerulonephritis, chronic rejection of renal allograft, and normal pregnancy may also lead to chronic LIC.…”

Section: Resultsmentioning

confidence: 99%

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Bilateral Phacomatosis Pigmentovascularis in a Young Male with Developmental Glaucoma and Varicose Veins

Singh¹,

Mutreja²,

Bhattacharyya³

et al. 2018

Journal of Current Glaucoma Practice

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Section: Resultsmentioning

confidence: 99%

“…Localized intravascular coagulopathy is seen as abnormally high D-dimer in few VMs. 4 Phleboliths are seen only in cases of sporadic VMs. Venous malformations are slow-flow vascular malformations present at birth, and LIC causes pain and thrombosis within a lesion and severe bleeding during surgical procedures.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Phacomatosis Pigmentovascularis in a Young Male with Developmental Glaucoma and Varicose Veins

Singh¹,

Mutreja²,

Bhattacharyya³

et al. 2018

Journal of Current Glaucoma Practice

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“…VM are accompanied by spontaneous thrombosis and thrombolysis (19,20). Coagulation disorders are the result of chronic venous blood stagnation within the large irregular vascular spaces, leading to activation of coagulation cascade reactions following production of thrombin, the conversion of fibrinogen into fibrin, which induces the blood clot formation.…”

Section: Discussionmentioning

confidence: 99%

A Diagnostic Program of Vascular Tumor and Vascular Malformations in Children According to Modern Classification

Benzar

2017

Acta Med. (Hradec Kralove, Czech Repub.)

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A B ST R AC T The aim of the study was to analyze the cohort of inpatient children with vascular anomalies according to the globally accepted classification introduced by the ISSVA. Methods: The study included 205 inpatient children within the time period of the years 2010-2015. Types of vascular anomalies (VAs), age of patients, diagnostic procedures, and anatomical localization of VAs were analyzed. Results: 65 patients of first year of life had vascular tumors, with prevalence of infantile hemangiomas (IHs) in 57 (87.7%) patients. 45 children had IHs localized within soft tissues, whereas 7 patients suffered from IHs of the liver, and 5 children from IHs of the respiratory tract. Most patients with soft tissue IHs were diagnosed only with ultrasound; СT or MRI diagnostics were performed on 5 (8.8%) patients, and biopsy was carried out in 2 (4.4%) children. Vascular malformations (VM) were diagnosed in 140 (68.3%) patients. Ultrasound investigation (US) was the screening method. MRI was performed to confirm the diagnosis of low-flow VM, whereas for high-flow VM CT angiography and selective angiography were useful. Venous malformations were diagnosed in 17 (12.1%) patients, and 112 (80.0%) had cystic LM, among them children under the age of 2 years prevailed. Arteriovenous malformations were diagnosed in 5 (3.8%) patients, ages 2-14 years. Conclusions: Clinical manifestations of vascular anomalies have clear age features. Among hospitalized children vascular tumors add up to 31.7% and VM -up to 68.3%.

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“…In a recent research Rootman et al [5] have demonstrated that CHs are noninfiltrating, focal venous malformations. They lack hyperplasia, that is, the cell turnover rate is not altered and they grow (when they do it, by an average 10 % per year) owing to phenomena of localized intravascular coagulation (LIC) and subsequent inflammation [6]. Just like other Puig Type I venous malformations, they are (almost) excluded from the general circulation [7].…”

mentioning

confidence: 99%

“…Small, asymptomatic malformations, especially those located intraconally, can be just observed over time. Nonsurgical measures such as low molecular weight heparin could be used to stem episodes of LIC [6].…”

mentioning

confidence: 99%

Cavernous hemangioma: a term to be canceled

Colletti

Deganello

2016

Eur Arch Otorhinolaryngol

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Many Authors still refer to “cavernous hemangioma”.\ud \ud To be correct, the term should indicate a tumor. Are cavernous hemangioma tumors? No. In a recent research Rootman et al. have demonstrated that CHs are non-infiltrating, focal venous malformations. They lack hyperplasia, that is, the cell turnover rate is not altered and they grow (when they do it, by an average 10 % per year) owing to phenomena of localized intravascular coagulation (LIC) and subsequent inflammation. Just like other Puig Type I venous malformations, they are (almost) excluded from the general circulation.\ud \ud Since isolated venous malformations of the orbit are not tumors, indications for surgery and, especially, the related informed consent must take this into consideration. Only those malformations presenting clear symptoms, like reduction in visual acuity and/or diplopia should be managed surgically. Another, less agreed on, indication is morphologically significant exophthalmos. Small, asymptomatic malformations, especially those located intraconally, can be just observed over time. Nonsurgical measures such as low molecular weight heparin could be used to stem episodes of LIC.\ud \ud Thus we believe that the term “cavernous hemangioma” should be canceled and replaced by Venous Malformation of the Orbit

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Association of Localized Intravascular Coagulopathy With Venous Malformations

Abstract: To determine which venous malformations (VMs) are at risk for coagulopathy. Venous malformations are slow-flow vascular malformations present at birth, and localized intravascular coagulopathy (LIC) causes pain and thrombosis within a lesion and severe bleeding during surgical procedures.

Cited by 294 publications

References 19 publications

Bilateral Phacomatosis Pigmentovascularis in a Young Male with Developmental Glaucoma and Varicose Veins

Bilateral Phacomatosis Pigmentovascularis in a Young Male with Developmental Glaucoma and Varicose Veins

A Diagnostic Program of Vascular Tumor and Vascular Malformations in Children According to Modern Classification

Cavernous hemangioma: a term to be canceled

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