Association of long-term effects of low-level sulfamethoxazole with ovarian lipid and amino acid metabolism, sex hormone levels, and oocyte maturity in zebrafish

Yu, Kuo-Tsong; Qiu, Yushu; Shi, Yi; Yu, Xiaogang; Dong, Ting; Wu, Yuhang; Li, Huajun; Huang, Lisu

doi:10.1016/j.ecoenv.2022.114234

Cited by 14 publications

(1 citation statement)

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“…SMZ and norfloxacin (NOR), a fluoroquinolone, both singularly or in combination (2, 20, and 200 μg/L) were able to diminish zebrafish’s daily egg production and increase embryo mortality and malformations at the highest dose [ 194 ]. Another antibiotic, Ciprofloxacin (CIP), was observed to act as an endocrine disruptor in zebrafish males exposed to 15.6 µg/mL for 21 days by affecting male steroidogenesis and altering the expression of testis gonadotropin receptors, genes related to the endocrine system, signal transduction, and membrane transport [ 195 ]. Moreover, zebrafish’s exposure to 6.25, 12.5, and 25 mg/L to β-diketone antibiotics (DKAs) from 6 hpf to 144 hpf [ 196 ] showed a disruption in steroidogenesis in a dose-dependent fashion once these embryos reached adulthood and triggered gonadal ultrastructural damage in both sexes, indicated by TEM microscopy [ 196 ].…”

Section: The Use Of Model Species To Investigate Reproductive Challen...mentioning

confidence: 99%

A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction

Lombó,

Giommi,

Zarantoniello

et al. 2024

Animals

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The Mediterranean region is facing several environmental changes and pollution issues. Teleosts are particularly sensitive to these challenges due to their intricate reproductive biology and reliance on specific environmental cues for successful reproduction. Wild populations struggle with the triad of climate change, environmental contamination, and overfishing, which can deeply affect reproductive success and population dynamics. In farmed species, abiotic factors affecting reproduction are easier to control, whereas finding alternatives to conventional diets for farmed teleosts is crucial for enhancing broodstock health, reproductive success, and the sustainability of the aquaculture sector. Addressing these challenges involves ongoing research into formulating specialized diets, optimizing feeding strategies, and developing alternative and sustainable feed ingredients. To achieve a deeper comprehension of these challenges, studies employing model species have emerged as pivotal tools. These models offer advantages in understanding reproductive mechanisms due to their well-defined physiology, genetic tractability, and ease of manipulation. Yet, while providing invaluable insights, their applicability to diverse species remains constrained by inherent variations across taxa and oversimplification of complex environmental interactions, thus limiting the extrapolation of the scientific findings. Bridging these gaps necessitates multidisciplinary approaches, emphasizing conservation efforts for wild species and tailored nutritional strategies for aquaculture, thereby fostering sustainable teleost reproduction in the Mediterranean.

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