Association of long term exposure to outdoor volatile organic compounds (BTXS) with pro-inflammatory biomarkers and hematologic parameters in urban adults: A cross-sectional study in Tabriz, Iran

Samadi, Mohammad; Shakerkhatibi, Mohammad; Poorolajal, Jalal; Rahmani, Alireza; Rafieemehr, Hassan; Hesam, Mousa

doi:10.1016/j.ecoenv.2019.05.008

“…Furthermore, significantly decreased HCT and increased MCHC were observed in individuals working in high traffic and industrial areas with high concentration of benzene [26], which was also consistent with our finding that at higher benzene exposure levels, MCHC increased and HCT decreased with increasing SPMA. However, a study conducted in children observed negative correlation between HCT and benzene at environmental exposure levels [27], which is contrary to our result that HCT increased with increasing SPMA at lower exposure levels.…”

Section: Discussionsupporting

confidence: 91%

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Zhang¹,

Deng²,

He

³

et al. 2020

Preprint

1

0

View full text Add to dashboard Cite

Background: Ubiquitously distributed benzene is a known hematotoxin. Increasing evidence has suggested that erythroid-related hematologic parameters may be sensitive to benzene exposure. Fat content, which is also closely associated with erythroid-related hematologic parameters, may affect the distribution and/or metabolism of benzene, and eventually benzene-induced toxicity. Methods: To explore the influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters, we recruited 1669 petrochemical workers and measured their urinary S-phenylmercapturic acid (SPMA) concentration and erythroid-related hematological parameters. Indices for fat content included body fat percentage (BF%), plasma total cholesterol (TC) and triglycerides (TG) , and occurrence of fatty liver. Results: The dose-response curve revealed U-shaped nonlinear relationships of SPMA with hematocrit (HCT) and mean corpuscular hemoglobin concentration (MCHC) ( P -overall <0.001, and P -nonlinear < 0.015), as well as positive linear associations and r-shaped nonlinear relationships of continuous fat content indices with erythroid-related hematological parameters ( P -overall ≤ 0.005). We also observed modification effects of fat content on the associations between benzene exposure and erythroid-related hematological parameters, with workers of lower or higher BF% and TG more sensitive to benzene-induced elevation of MCHC ( P interaction =0.021) and benzene-induced decrease of HCT ( P interaction = 0.050), respectively. We also found that some erythroid-related hematologic parameters differed between subgroups of workers with different SPMA levels and fat content combination. Conclusions: Our study suggested that benzene exposure, fat content, and their interactions may affect erythroid-related hematological parameters in petrochemical workers in a complex manner that are worthy of further investigation.

show abstract

“…MCHC was found to be inversely associated with blood benzene in residents living near petrochemical areas at environmental exposure concentration [25], which was consistent with our finding that at lower benzene exposure levels, MCHC decreased with increasing SPMA. Furthermore, significantly decreased HCT and increased MCHC were observed in individuals working in high traffic and industrial areas with high concentration of benzene [26], which was also consistent with our finding that at higher benzene exposure levels, MCHC increased and HCT decreased with increasing SPMA. However, a study conducted in children observed negative correlation between HCT and benzene at environmental exposure levels [27], which is contrary to our result that HCT increased with increasing SPMA at lower exposure levels.…”

Section: Discussionsupporting

confidence: 91%

“…Additionally, benzene exposure and high fat content can both induce excessive reactive oxygen species which might cause erythrocytic dysfunction and cell apoptosis, ultimately making RBCs more easily absorbed by spleen and inducing abnormal blood cell counts [42,43]. Benzene exposure can also increase the production of proinflammatory cytokine [26], and obese individuals are considered to be in a low-grade inflammatory state [44]. Studies have indicated that cytokines and inflammatory environment might both interfere with the RBC maturation in bone marrow [45].…”

Section: Discussionmentioning

confidence: 99%

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Zhang

¹

,

Deng

²

,

He

³

et al. 2020

View full text Add to dashboard Cite

Background: Ubiquitously distributed benzene is a known hematotoxin. Increasing evidence has suggested that erythroid-related hematologic parameters may be sensitive to benzene exposure. Fat content, which is also closely associated with erythroid-related hematologic parameters, may affect the distribution and/or metabolism of benzene, and eventually benzene-induced toxicity. Methods: To explore the influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters, we recruited 1669 petrochemical workers and measured their urinary S-phenylmercapturic acid (SPMA) concentration and erythroid-related hematological parameters. Indices for fat content included body fat percentage (BF%), plasma total cholesterol (TC) and triglycerides (TG), and occurrence of fatty liver. Results: The dose-response curve revealed U-shaped nonlinear relationships of SPMA with hematocrit (HCT) and mean corpuscular hemoglobin concentration (MCHC) (P-overall < 0.001, and P-nonlinear < 0.015), as well as positive linear associations and r-shaped nonlinear relationships of continuous fat content indices with erythroid-related hematological parameters (P-overall ≤0.005). We also observed modification effects of fat content on the associations between benzene exposure and erythroid-related hematological parameters, with workers of lower or higher BF% and TG more sensitive to benzene-induced elevation of MCHC (P interaction = 0.021) and benzene-induced decrease of HCT (P interaction = 0.050), respectively. We also found that some erythroid-related hematologic parameters differed between subgroups of workers with different SPMA levels and fat content combination.

show abstract

“…Furthermore, significantly decreased HCT and increased MCHC were observed in individuals working in high traffic and industrial areas with high concentration of benzene [26], which was also consistent with our finding that at higher benzene exposure levels, MCHC increased and HCT decreased with increasing SPMA. However, a study conducted in children observed negative correlation between HCT and benzene at environmental exposure levels [27], which is contrary to our result that HCT increased with increasing SPMA at lower exposure levels.…”

Section: Discussionsupporting

confidence: 91%

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Zhang¹,

Deng²,

He

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background: Ubiquitously distributed benzene is a known hematotoxin. Increasing evidence has suggested that erythroid-related hematologic parameters may be sensitive to benzene exposure. Fat content, which is also closely associated with erythroid-related hematologic parameters, may affect the distribution and/or metabolism of benzene, and eventually benzene-induced toxicity. Methods: To explore the influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters, we recruited 1669 petrochemical workers and measured their urinary S-phenylmercapturic acid (SPMA) concentration and erythroid-related hematological parameters. Indices for fat content included body fat percentage (BF%), plasma total cholesterol (TC) and triglycerides (TG) , and occurrence of fatty liver. Results: The dose-response curve revealed U-shaped nonlinear relationships of SPMA with hematocrit (HCT) and mean corpuscular hemoglobin concentration (MCHC) ( P -overall <0.001, and P -nonlinear < 0.015), as well as positive linear associations and r-shaped nonlinear relationships of continuous fat content indices with erythroid-related hematological parameters ( P -overall ≤ 0.005). We also observed modification effects of fat content on the associations between benzene exposure and erythroid-related hematological parameters, with workers of lower or higher BF% and TG more sensitive to benzene-induced elevation of MCHC ( P interaction =0.021) and benzene-induced decrease of HCT ( P interaction = 0.050), respectively. We also found that some erythroid-related hematologic parameters differed between subgroups of workers with different SPMA levels and fat content combination. Conclusions: Our study suggested that benzene exposure, fat content, and their interactions may affect erythroid-related hematological parameters in petrochemical workers in a complex manner that are worthy of further investigation.

show abstract

Association of long term exposure to outdoor volatile organic compounds (BTXS) with pro-inflammatory biomarkers and hematologic parameters in urban adults: A cross-sectional study in Tabriz, Iran

Cited by 41 publications

References 49 publications

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Influence of benzene exposure, fat content, and their interactions on erythroid-related hematologic parameters in petrochemical workers: a cross-sectional study

Contact Info

Product

Resources

About