Association of Long-term Strenuous Physical Activity and Extensive Sitting With Incident Radiographic Knee Osteoarthritis

Abstract

IMPORTANCE Persons with knee symptoms recognize the health benefits of engaging in physical activity, but uncertainty persists about whether regular strenuous physical activity or exercise can accelerate tissue damage. A sedentary lifestyle of inactivity or underloading may also be associated with deleterious joint health. OBJECTIVE To establish whether long-term strenuous physical activity participation and extensive sitting behavior are each associated with increased risk of developing radiographic knee osteoarthritis (KOA) in individuals at high risk for the disease. DESIGN, SETTING, AND PARTICIPANTS This cohort study analyzed data from the Osteoarthritis Initiative, a prospective longitudinal cohort study of men and women with or at an increased risk of developing symptomatic, radiographic KOA. Community-dwelling adults were recruited from 4 US sites

Musculoskeletal pain and sedentary behaviour in occupational and non-occupational settings: a systematic review with meta-analysis

“…The lowest scores in these categories were 0.41 for Aweto et al [ 58 ], a cross-sectional study in the general population category; 0.36 for Omokhodion et al [ 94 ], a cross-sectional study in the observational-occupational category; and 0.42 for Engelen et al [ 122 ], a non-RT without control design pilot study in the experimental/intervention category. The highest score among the general population category was 0.95 scored in six studies [ 16 , 64 , 66 , 67 , 75 , 76 ]. In the occupational category, the highest score in observational studies was 0.95 scored by six studies [ 39 , 57 , 100 , 109 , 114 , 129 ], and in experimental/intervention studies was 0.96 for one study, Brakenridge et al [ 121 ].…”

“…Four high-quality cross-sectional studies, three of adults ≥ 45 years in the general population cohorts [ 16 , 59 , 60 ] and one study of adults < 40 years in the occupational cohorts [ 105 ] reported a positive association of full-day SB with knee pain (osteoarthritis), including one study that reported the association only in men [ 59 ]. There was one prospective study [ 76 ] that reported no association of extensive full-day SB with knee pain. According to the best-evidence synthesis, we concluded there is strong evidence of cross-sectional association of full-day SB with knee pain in middle-aged to older adults, however, there is insufficient evidence whether the association is gender-dependent.…”

The Association of Physical (in)Activity with Mental Health. Differences between Elder and Younger Populations: A Systematic Literature Review

“…As is common in the literature, when an individual scores above that cut-off, this individual was considered to have clinically relevant symptoms of a MH disorder. We also included 2 studies [ 38 , 53 ] that, even though they used a validated MH scale, did not use a specific cut-off but rather performed analysis by categories of severity of symptoms.…”

Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis

“…Although moderate physical activity is encouraged to improve one's general health, repetition or incorrect execution of movements is the prevailing cause of OA in both young and older adults ( 56 , 64 , 107 ). From a comprehensive review of recent studies, common occupational activities such as sitting (hip and knee OA), lifting (knee OA), driving (knee OA), and squat (lower limb OA) have been associated with increased risk of OA ( 108 , 109 ).…”