Association of low birth weight and placental malarial infection in Nigeria

Aribodor, DN; Nwaorgu, O. C.; Eneanya, CI; Okoli, Ikechukwu; Pukkila-Worley, Reed; Etaga, Harrison O

doi:10.3855/jidc.554

Cited by 28 publications

(23 citation statements)

References 13 publications

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“…2 A Nigerian study found a prevalence of 64% for placental malaria. 4 Placental malaria can lead to placental insufficiency. It is hypothesized that insufficiency is the consequence of a local release of inflammation mediators due to a placental inflammatory reaction to the infected erythrocytes.…”

Section: Introductionmentioning

confidence: 99%

Placental malaria and the relationship to pregnancy outcome at Gushegu District Hospital, Northern Ghana

Spronsen

Schneider

Atasige³

2012

Trop Doct

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One complication of malaria infection during pregnancy is the sequestration of parasites in the placenta. The aim of this study was to determine the association between placental malaria and pregnancy outcome. This study was conducted at the Gushegu District Hospital in Ghana from June to August 2010. Sulfadoxine-pyrimethamine (SP) was used as intermittent preventative treatment (IPT) during pregnancy. All mothers reporting for delivery were enrolled, except in cases of multiple pregnancies. The data was documented using a questionnaire. A placental blood sample was collected and analysed for malaria parasites. There were 56/107(52%) malaria positive samples. In women with placental malaria perinatal mortality was higher, duration of pregnancy shorter and birth weight lower. These results were statistically significant. In primigravidae the negative effects were more obvious. IPT is extensively implemented in Ghana, but this study found no evidence for an association between the number of doses and the outcome of pregnancy.

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Section: Introductionmentioning

confidence: 99%

Placental malaria and the relationship to pregnancy outcome at Gushegu District Hospital, Northern Ghana

Spronsen

Schneider

Atasige³

2012

Trop Doct

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“…Binding is mediated by VAR2CSA (variant surface antigen 2-chondroitin sulfate A), a variant antigen of the PfEMP1 family expressed on the surface of IE by the parasite (45,46). P. falciparum infections during pregnancy have been associated with maternal anemia and poor pregnancy outcomes, specifically, low birth weight babies (4,6,19,27,29). Low birth weight is a major cause of neonatal and infant mortality in both developed and developing countries (25,36,55) and may be associated with long-term health consequences (28,30,36,43).…”

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confidence: 99%

High Levels of Antibodies to Multiple Domains and Strains of VAR2CSA Correlate with the Absence of Placental Malaria in Cameroonian Women Living in an Area of High Plasmodium falciparum Transmission

et al. 2012

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ABSTRACTPlacental malaria, caused by sequestration ofPlasmodium falciparum-infected erythrocytes in the placenta, is associated with increased risk of maternal morbidity and poor birth outcomes. The parasite antigen VAR2CSA (variant surface antigen 2-chondroitin sulfate A) is expressed on infected erythrocytes and mediates binding to chondroitin sulfate A, initiating inflammation and disrupting homeostasis at the maternal-fetal interface. Although antibodies can prevent sequestration, it is unclear whether parasite clearance is due to antibodies to a single Duffy binding-like (DBL) domain or to an extensive repertoire of antibodies to multiple DBL domains and allelic variants. Accordingly, plasma samples collected longitudinally from pregnant women were screened for naturally acquired antibodies against an extensive panel of VAR2CSA proteins, including 2 to 3 allelic variants for each of 5 different DBL domains. Analyses were performed on plasma samples collected from 3 to 9 months of pregnancy from women living in areas in Cameroon with high and low malaria transmission. The results demonstrate that high antibody levels to multiple VAR2CSA domains, rather than a single domain, were associated with the absence of placental malaria when antibodies were present from early in the second trimester until term. Absence of placental malaria was associated with increasing antibody breadth to different DBL domains and allelic variants in multigravid women. Furthermore, the antibody responses of women in the lower-transmission site had both lower magnitude and lesser breadth than those in the high-transmission site. These data suggest that immunity to placental malaria results from high antibody levels to multiple VAR2CSA domains and allelic variants and that antibody breadth is influenced by malaria transmission intensity.

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“…Alguns estudos de freqüência na África indicam uma contribuição de 35% da malária para o BPN, que pode ser resultante de partos prematuros e restrição do crescimento intra-uterino (MCGREGOR, 1984;STEKTEE et al, 2001;ARIBODOR et al, 2009).…”

Section: Consequencias Da Malária Na Gestaçãounclassified

Malária em gestantes no município de Cruzeiro do Sul pertencente à região amazônica brasileira

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Association of low birth weight and placental malarial infection in Nigeria

Cited by 28 publications

References 13 publications

Placental malaria and the relationship to pregnancy outcome at Gushegu District Hospital, Northern Ghana

Placental malaria and the relationship to pregnancy outcome at Gushegu District Hospital, Northern Ghana

High Levels of Antibodies to Multiple Domains and Strains of VAR2CSA Correlate with the Absence of Placental Malaria in Cameroonian Women Living in an Area of High Plasmodium falciparum Transmission

Malária em gestantes no município de Cruzeiro do Sul pertencente à região amazônica brasileira

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