Association of Low CD4/CD8 Ratio With Adverse Cardiac Mechanics in Lymphopenic HIV-Infected Adults

Sinha, Arjun; Mystakelis, Harry; Rivera, Adovich S.; Manion, Maura; Laidlaw, Elizabeth; Mejia, Yolanda; Rupert, Adam; Robby, Greg; Sheikh, Virginia; Sereti, Irini; Feinstein, Matthew J.

doi:10.1097/qai.0000000000002465

Cited by 2 publications

(3 citation statements)

References 16 publications

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“…Fifteen studies that met the quality appraisal are included in the systematic review, as discussed in Table 1 [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28].…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, the study by Sinha et al involved 270 patients. The authors found that post-ART echocardiography showed higher right ventricular systolic pressure in subjects with lower CD4/CD8 ratios after antiretroviral therapy initiation [ 20 ]. It is associated with a higher risk of cancer when CD4 counts are low in HF in the broader HIV population, according to recent studies.…”

Section: Reviewmentioning

confidence: 99%

“…It is associated with a higher risk of cancer when CD4 counts are low in HF in the broader HIV population, according to recent studies. The mechanistic and clinical studies of HIV-related CD4 lymphopenia need to determine whether it is a cause of cardiac dysfunction or HF or a proxy marker for other virological and inflammatory factors leading to HF [ 20 ].…”

Section: Reviewmentioning

confidence: 99%

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A Systematic Review Exploring the Effect of Human Immunodeficiency Virus on Cardiac Diseases

Alzubaidee¹,

Dwarampudi²,

Mathew³

et al. 2022

Cureus

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Human immunodeficiency virus (HIV) primarily affects the immune systems, which, if progressed, will lead to acquired immunodeficiency syndrome (AIDS). Currently, there is no effective cure for the disease, and patients are affected lifelong, but there are antiretroviral medications that can control the disease's symptoms and progression. In addition, taking precautions during sexual contact, especially in the male homosexual population, while handling the patient's bodily fluids such as blood and saliva, and during childbirth by an infected mother is necessary to prevent the transmission of the virus. We used 15 studies, including systematic reviews and meta-analyses, observation studies, randomized clinical trials, and comprehensive reviews, to determine how HIV interferes with heart disease, increasing morbidity and mortality. We have used specific inclusion and exclusion criteria, focusing on specified age groups within a particular timeline. Some of the included studies found that many side effects from antiretroviral drugs can impact heart conditions, along with HIV, while others did not show a strong correlation between HIV and some heart diseases. In conclusion, after reviewing the literature, the results are inconclusive. More extensive trials focusing on the impact HIV has on heart disease are required to establish a strong correlation between HIV and heart disease to prevent morbidity and mortality.

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“…Fifteen studies that met the quality appraisal are included in the systematic review, as discussed in Table 1 [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28].…”

Section: Resultsmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

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