Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction

Meng, Heyu; Li, Lihong; Ruan, Jianjun; Chen, Yanqiu; Yan, Zhaohan; Liu, Jinsha; Li, Xiangdong; Mao, Cuiying; Yang, Ping

doi:10.1155/2022/7981637

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…In terms of cardiovascular pathologies, NUMB has been proposed as an indicator of an increased risk of coronary artery disease. In this case, lower NUMB expression indicates a higher risk of developing the disease [208]. In addition, NUMB has also been proposed as a therapeutic candidate for muscle and cardiac regeneration, as well as for congenital heart disease [209,210].…”

Section: Numb As a Therapeutic Tool For Various Pathologiesmentioning

confidence: 99%

The Multitasker Protein: A Look at the Multiple Capabilities of NUMB

Ortega-Campos

García-Heredia

2023

Cells

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NUMB, a plasma membrane-associated protein originally described in Drosophila, is involved in determining cell function and fate during early stages of development. It is secreted asymmetrically in dividing cells, with one daughter cell inheriting NUMB and the other inheriting its antagonist, NOTCH. NUMB has been proposed as a polarizing agent and has multiple functions, including endocytosis and serving as an adaptor in various cellular pathways such as NOTCH, Hedgehog, and the P53-MDM2 axis. Due to its role in maintaining cellular homeostasis, it has been suggested that NUMB may be involved in various human pathologies such as cancer and Alzheimer’s disease. Further research on NUMB could aid in understanding disease mechanisms and advancing the field of personalized medicine and the development of new therapies.

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Section: Numb As a Therapeutic Tool For Various Pathologiesmentioning

confidence: 99%

The Multitasker Protein: A Look at the Multiple Capabilities of NUMB

Ortega-Campos

García-Heredia

2023

Cells

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“…Peripheral blood can be used as a window to evaluate diseases [ 48 , 49 , 50 ]. It is convenient for sampling and causes minimal harm [ 51 ].…”

Section: Sampling Positionmentioning

confidence: 99%

Trace Elements Open a New Direction for the Diagnosis of Atherosclerosis

Meng¹,

Ruan²,

Chen³

et al. 2023

Rev. Cardiovasc. Med.

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Abnormal or excessive accumulation of adipose tissue leads to a condition called obesity. Long-term positive energy balance arises when energy intake surpasses energy expenditure, which increases the risk of metabolic and other chronic diseases, such as atherosclerosis. In industrialized countries, the prevalence of coronary heart disease is positively correlated with the human development index. Atherosclerotic cardiovascular disease (ACD) is among the primary causes of death on a global scale. There is evidence to support the notion that individuals from varied socioeconomic origins may experience varying mortality effects as a result of high blood pressure, high blood sugar, raised cholesterol levels, and high body mass index (BMI). However, it is believed that changes in the concentration of trace elements in the human body are the main contributors to the development of some diseases and the transition from a healthy to a diseased state. Metal trace elements, non-metal trace elements, and the sampling site will be examined to determine whether trace elements can aid in the diagnosis of atherosclerosis. This article will discuss whether trace elements, discussed under three sections of metal trace elements, non-metal trace elements, and the sampling site, can participate in the diagnosis of atherosclerosis.

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“…The expression level of the adior2 gene, for example, is linked to the advancement of coronary atherosclerosis [ 70 ]. Meng et al revealed that numb ABCB1, ACSL1, ZHHC9, and other genes have important roles in the pathogenesis of atherosclerosis [ 71 , 72 , 73 , 74 ]. Furthermore, a study from the University of Washington discovered that the SVEP1 gene causes atherosclerosis in the absence of cholesterol [ 75 ].…”

Section: Gene and Protein Markersmentioning

confidence: 99%

New Progress in Early Diagnosis of Atherosclerosis

Meng

Ruan

Yan

et al. 2022

IJMS

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Coronary atherosclerosis is a potentially chronic circulatory condition that endangers human health. The biological cause underpinning cardiovascular disease is coronary atherosclerosis, and acute cardiovascular events can develop due to thrombosis, platelet aggregation, and unstable atherosclerotic plaque rupture. Coronary atherosclerosis is progressive, and three specific changes appear, with fat spots and stripes, atherosclerosis and thin-walled fiber atherosclerosis, and then complex changes in arteries. The progression and severity of cardiovascular disease are correlated with various levels of calcium accumulation in the coronary artery. The therapy and diagnosis of coronary atherosclerosis benefit from the initial assessment of the size and degree of calcification. This article will discuss the new progress in the early diagnosis of coronary atherosclerosis in terms of three aspects: imaging, gene and protein markers, and trace elements. This study intends to present the latest methods for diagnosing patients with early atherosclerosis through a literature review.

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Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction

Cited by 3 publications

References 37 publications

The Multitasker Protein: A Look at the Multiple Capabilities of NUMB

The Multitasker Protein: A Look at the Multiple Capabilities of NUMB

Trace Elements Open a New Direction for the Diagnosis of Atherosclerosis

New Progress in Early Diagnosis of Atherosclerosis

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