Association of low Interleukin-10 levels with the metabolic syndrome in obese women

Monocytes from Metabolic Syndrome Subjects Exhibit a Proinflammatory M1 Phenotype

“…4,5,17 In addition to increased M1 phenotype levels in metabolic syndrome subjects, there is also a significantly decreased alternative M2 phenotype, as characterized by the IL-10, CD163, and CD206 markers. Also, Esposito et al 19 have reported decreased IL-10 levels in obese women with metabolic syndrome, as seen in our study. We were unable to look at gender differences in the parameters studied due to the small sample size.…”

Interleukin-10 is a protective factor against diet-induced insulin resistance in liver

“…In addition to the use of immunoblotting to evaluate the efficiency of the methods to inhibit IL-10, we performed a glucose tolerance test to determine the effect of these approaches on whole body glucose homeostasis. In two previous studies, different means used to modulate IL-10 in vivo led, invariably, to changes in whole body glucose disposal [16,30]. Therefore, we believe that the increased glucose under curve during the ipGTT in mice treated with the IL-10 AS or with the IL-10 Ab provides further evidence for the efficiency of the methods employed.…”

“…In agreement with the known immunomodulatory activity of IL-10 in other tissues, a number of studies have reported a role for IL-10 as a protective factor against liver damage in diseases such as experimental hepatitis induced by LPS and concanavalin A [25,26], schistosomiasis [27], alcoholic hepatitis [28], and hepatitis C virus infection [29]. More recently, some groups have reported a protective role for IL-10 in fatty liver disease [16,30].…”

Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease

“…IL-10 levels have been found to be decreased in obese and diabetic patients, which relates positively to the insulin sensitivity of patients with NASH [38]. IL-10 levels have also been found to be lower in women with metabolic syndrome than in women without metabolic syndrome [39]. However, Calcaterra et al [40] found that metabolic syndrome was not associated with a low level of IL-10.…”