Association of low serum 25-hydroxyvitamin D levels with the frailty syndrome in Mexican community-dwelling elderly

Gutiérrez‐Robledo, Luis Miguel; Ávila-Fuñes, José Alberto; Amieva, Hélène; Meillon, Céline; Acosta, José Luís; Navarrete‐Reyes, Ana Patricia; Torres-Carrillo, Norma; Muñoz‐Valle, José Francisco

doi:10.3109/13685538.2015.1105796

Cited by 21 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14 This result is of concern, if we consider that a high inadequacy was also observed in calcium intake and that the lack of both of these nutrients predisposes this population to a greater risk of osteoporosis, frailty, 29 falls, 30 fractures, 31,32 functional dependency 33 and loss of muscle function. 34 In a random sample of 158 Mexican OA of the 2006 Ensanut, 33% had suboptimal concentrations of vitamin D. 35 This problem has been recently documented in Latin America.…”

Section: Discussionmentioning

confidence: 99%

Dietary intake and adequacy of energy and nutrients in Mexican older adults: results from two National Health and Nutrition Surveys

et al. 2017

View full text Add to dashboard Cite

Quantile and logistic regression models were used to obtain medians and marginal effects of each nutrient, adjusting by confounders and survey design. Results. Dietary intake of energy and nutrients was similar in both surveys. Most common micronutrients at risk of dietary deficiency were, for vitamins: A, B-12, C, D and folate, and for minerals: calcium, iron and zinc, in both surveys. Excessive intake of sugar and saturated fat and low fiber intake were common. Conclusions. Diet in older Mexican adults is low in micronutrient essentials, and excessive in fat and sugar. Attention to the diet in this age group through targeted interventions is necessary to promote a healthy diet.Keywords: diet; older adults; nutritional deficiencies; micronutrients; Mexico

show abstract

Section: Discussionmentioning

confidence: 99%

Dietary intake and adequacy of energy and nutrients in Mexican older adults: results from two National Health and Nutrition Surveys

et al. 2017

View full text Add to dashboard Cite

show abstract

“…An analysis of the Toledo Study for Healthy Aging (n=592) reported that low serum 25OHD was associated with frailty (OR 1.65 95% CI 1.02-2.67, p=0.04), defined using the phenotype model(19). These findings were supported by an analysis of the European Male Ageing Study (n=1504) (88), a Mexican study of over 70s (n=331)(89), and a large Austrian study (n=940)(90), which also observed significant associations between low serum 25OHDand individual components of frailty including physical exhaustion, inactivity and reduced gait speed. A smaller Taiwanese study (n=215), reported a strong association between vitamin D status and frailty (odds ratio, OR, 10.CI 2.6 to 44.3) (91).…”

mentioning

confidence: 88%

Frailty and the endocrine system

Clegg

Hassan‐Smith

2018

The Lancet Diabetes & Endocrinology

178

View full text Add to dashboard Cite

Frailty is a condition characterised by loss of biological reserves, failure of homoeostatic mechanisms, and vulnerability to adverse outcomes. The endocrine system is considered particularly important in frailty, because of its complex inter-relationships with the brain, immune system, and skeletal muscle. This Review summarises evidence indicating a key role for the hypothalamic-pituitary axis in the pathogenesis of frailty through aberrant regulation of glucocorticoid secretion, insulin-like growth factor signalling, and androgen production. Evidence also indicates a potential role for vitamin D and insulin resistance in the pathogenesis of frailty. The role of thyroid hormones in the pathogenesis of frailty remains uncertain. Key convergent pathological effects of frailty include loss of muscle mass and strength, with consequent impact on mobility and activities of daily living. Future translational research should focus on the understanding of endocrine mechanisms, to identify potential biomarkers of the condition, modifiable targets for treatment, and novel pharmacological drugs targeted at the endocrine components of frailty.

show abstract

“…[ 8 ] In regard to the elderly, a direct association between low 25(OH)D levels and frailty syndrome has recently been reported. [ 9 ]…”

Section: Introductionmentioning

confidence: 99%

“…[8] In regard to the elderly, a direct association between low 25(OH)D levels and frailty syndrome has recently been reported. [9] It is worth mentioning, here, that VD also has noncalcemic and nonskeletal effects. Several studies have reported an inverse association between VD levels and the risk of oral, gastrointestinal, urinary, ocular, and respiratory infections.…”

mentioning

confidence: 95%

Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status

Kweder¹,

Eidi

2018

Avicenna J Med

View full text Add to dashboard Cite

Introduction:Vitamin D (VD) deficiency is a major public health problem worldwide. In spite of its high prevalence, particularly among elderly people, VD deficiency is still underestimated by many physicians. Increasingly, VD deficiency is associated with several known geriatric syndromes.Methods:The study sample consisted of 125 patients, aged 75 years and older, admitted to the acute geriatric unit. The plausible association between the serum 25-hydroxyvitamin D [25(OH)D] level and patient age, sex, body mass index, renal function, cholecystectomy history, and the prescribed drugs had been investigated. The Fisher's exact test was used to conduct the statistical analysis of data.Results:Surprisingly, furosemide treatment was correlated with normal 25(OH)D levels and an increased incidence of secondary hyperparathyroidism. Unlike the other four parameters mentioned above, our data showed that only the patient sex exhibited a significant association with 25(OH)D level as elderly males suffered from a serious VD deficiency as compared to elderly females.Conclusion:Old age is an independent risk factor for VD deficiency. The supplementary dose of VD should be precisely defined to achieve the optimal serum 25(OH)D level in elderly people. The definition of the normal serum 25(OH)D threshold in elderly furosemide-treated patients is worth of further studies.

show abstract

Association of low serum 25-hydroxyvitamin D levels with the frailty syndrome in Mexican community-dwelling elderly

Abstract: These results suggest that older adults with low 25(OH)-vitamin D levels are associated with the probability to being frail compared with those with sufficient vitamin D levels.

Cited by 21 publications

References 30 publications

Dietary intake and adequacy of energy and nutrients in Mexican older adults: results from two National Health and Nutrition Surveys

Dietary intake and adequacy of energy and nutrients in Mexican older adults: results from two National Health and Nutrition Surveys

Frailty and the endocrine system

Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status

Contact Info

Product

Resources

About