Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women

Sassi, R.; Sahli, H.; Souissi, C.; Mahmoudi, Hejer El; Zouari, B.; Elgaaied, Amel Ben Ammar; Sellami, Slaheddine; Ferrari, Serge

doi:10.1186/1471-2474-15-144

Cited by 13 publications

(12 citation statements)

References 37 publications

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“…They discussed that this was aligned with other researchers finding where they determined association of A1330V with lumbar spine BMD in Asians. However, in Caucasian populations the association was observed in both spine and femoral neck BMD [58]. Park SE et al (2014) found an association with LRP5 rs599083 and femoral neck BMD in Korean men [59].…”

Section: Lrp Mutations In Bone Related Diseasesmentioning

confidence: 99%

LRP receptor family member associated bone disease

Lara-Castillo

Johnson

2015

Rev Endocr Metab Disord

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A dozen years ago the identification of causal mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene involved in two rare bone disorders propelled research in the bone field in totally new directions. Since then, there have been an explosion in the number of reports that highlight the role of the Wnt/β-catenin pathway in the regulation of bone homeostasis. In this review we discuss some of the most recent reports (in the past 2 years) highlighting the involvement of the members of the LRP family (LRP5, LRP6, LRP4, and more recently LRP8) in the maintenance of bone and their implications in bone diseases. These reports include records of new single nucleotides polymorphisms (SNPs) and haplotypes that suggest variants in these genes can contribute to subtle variation in bone traits to mutations that give rise to extreme bone phenotypes. All of these serve to further support and reinforce the importance of this tightly regulated pathway in bone. Furthermore, we discuss provocative reports suggesting novel approaches through inhibitors of this pathway to treat rarer diseases such as Osteoporosis-Pseudoglioma Syndrome (OPPG), Osteogenesis Imperfecta (OI), and Sclerosteosis/Van Buchem disease. It is hoped that by understanding the role of each component of the pathway and their involvement in bone diseases that this knowledge will allow us to develop new, more effective therapeutic approaches for more common diseases such as post-menopausal osteoporosis, osteoarthritis, and rheumatoid arthritis as well as these rarer bone diseases.

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Section: Lrp Mutations In Bone Related Diseasesmentioning

confidence: 99%

LRP receptor family member associated bone disease

Lara-Castillo

Johnson

2015

Rev Endocr Metab Disord

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“…Recently, a number of polymorphisms have been described in the LRP5 gene (http://www.ncbi.nlm.nih.gov/SNP). Among them, the Ala1330Val (rs3736228, exon 18) polymorphism has been studied most extensively (van Meurs et al, 2008) and was found to affect bone mineral density (Sassi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Association of LRP5 Ala1330Val polymorphism with fracture risk: a meta-analysis

Peng

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between the Ala1330Val polymorphism of the low-density lipoprotein receptor-related proteins 5 (LRP5) gene and fracture risk. However, the specific association is still controversial. The aim of this study was to investigate their correlation via metaanalysis. and EMBASE databases were searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Statistical analysis was performed using the STATA 12.0 software. Seven studies, involving 808 cases and 1586 controls, were included in the analysis. Meta-analysis results showed no significant association between the LRP5 Ala1330Val polymorphism and fracture risk (ValVal vs AlaAla: OR = 1.25, 95%CI = 0.82-1.91; AlaVal vs AlaAla: OR = 1.16, 95%CI = 0.95-1.42; dominant model: OR = 1.77, 95%CI = 0.96-1.41; recessive model: OR = 1.21, 95%CI = 0.80-1.83). Taking into account the effect of ethnicity, the LRP5 Ala1330Val polymorphism was not associated with the risk of fracture in Asians or Caucasians. The results of the current meta-analysis indicate that the LRP5 Ala1330Val polymorphism may not be correlated with fracture susceptibility.

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“…Significant associations were seen with seven SNPs, one of them is VDR SNP rs731246. In consistency, analysis of LRP5 polymorphisms in postmenopausal North African (Tunisian) women showed no association with BMD at any sites [48].…”

Section: Non-modifiable Risk Factors Modifiable Risk Factorsmentioning

confidence: 86%

Epidemiology and awareness of osteoporosis: a viewpoint from the Middle East and North Africa

Hammam¹

2018

Int. J. Clin. Rheumatol

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Background: Osteoporosis (OP) is defined by low bone mass and microstructural deterioration. It is an escalating public health problem due to increase life expectancy and the resulting bone fractures represent a significant burden for both the individual and the society in terms of morbidity, mortality and cost. Osteoporosis, a multifactorial disease, results from the interaction between genetic and environmental risk factors. Currently, the data available regarding OP epidemiology and predisposing risk factors differ greatly between regions and within population ethnicities. Proper estimation of the epidemiology of OP and its health related outcomes can help identity those at risk and permit prophylactic treatment before its occurrence. The main barrier towards disease prevention strategies is the impaired awareness of the disease and its risk. Enhanced understanding of the OP disease may influence personal behaviors and reduce its prevalence.Objectives: This review was undertaken to wrap-up and throw-light on the published literatures related to the epidemiology of osteoporosis in the Middle East and North Africa (MENA) region, and expose the extent of awareness in the corresponding populations. Describing and discussing key points on the current state of knowledge on these hot issues are well thought-out.Conclusion: Osteoporosis prevalence is variable among MENA populations. Limited reports regarding the established prevalence of osteoporotic fractures among those populations and therefore, lack of guidelines for prevention and management were noticed. In order to improve bone health, preventive measures against OP should be considered. Increase OP awareness and preventive practices in the societies as part of the prophylactic strategy need to be initiated.

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Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women

Cited by 13 publications

References 37 publications

LRP receptor family member associated bone disease

LRP receptor family member associated bone disease

Association of LRP5 Ala1330Val polymorphism with fracture risk: a meta-analysis

Epidemiology and awareness of osteoporosis: a viewpoint from the Middle East and North Africa

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