Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis

Abstract

Background: This meta-analysis evaluated the association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility. Methods: We searched the Scopus, PubMed/Medline, Web of Science, and Cochrane Library databases to retrieve articles published by October 2019. Review Manager 5.3 software was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). The results of publication bias tests were retrieved by Comprehensive Meta-Analysis 2.0 software. Results: A total of 150 relevant records were identified; out of which, 16 were entered into the analysis (4 studies assessed LTF, 11 ENAM, and 11 AMELX polymorphisms). Of all polymorphisms, there was a significant association only between ENAM rs3796704 polymorphism and dental caries susceptibility. Both ENAM rs3796704 and AMELX rs17878486 polymorphisms had a significant association with dental caries risk in the Caucasian ethnicity and the studies including caries-free control group. Conclusions: The results of this meta-analysis showed that the G allele and the GG genotype of ENAM rs3796704 were associated with an increased risk of caries in the case group compared with the control group. But there was no association between LTF rs1126478, ENAM (rs1264848 and rs3796703), and AMELX (rs946252, rs17878486, and rs2106416) polymorphisms and dental caries susceptibility.

Polymorphisms in genes expressed during amelogenesis and their association with dental caries: a case–control study

“…In a meta-analysis that included 4 studies [38,[48][49][50], Sharifi et al [51] did not prove any significant association between the SNPs in AMELX (rs946252 or rs17878486) and dental caries. Sensitivity analysis, however, indicated that AMELX (rs17878486) could be a risk factor for dental caries, which might have been hidden by other effective factors, namely, the ethnicity and type of selected controls.…”

AMELX and ENAM Polymorphisms and Dental Caries

“…Sharifi et al [ 13 ] in a meta-analysis study found that ENAM rs3796704 polymorphism, especially in the Caucasus ethnic group and in studies with caries-free individuals as a control group, had a higher risk of caries, but they found no association between polymorphisms LTF rs1126478, ENAM (rs1264848 and rs3796703), and AMELX (rs946252, rs17878486, and rs2106416) and susceptibility to dental caries. However, sensitivity analysis showed that AMELX rs17878486 polymorphism can be a risk factor for dental caries, but race and type of the control group are the factors influencing the relationship between AMELX rs17878486 polymorphism and the risk of dental caries.…”