Association of Lung Cancer and Tea-Drinking Habits of Different Subgroup Populations: Meta-Analysis of Case-Control Studies and Cohort Studies

Abstract

<jats:p>Background: We aimed to investigate the association between lung cancer and tea-drinking habits of different subgroup populations. Methods: Systematic search of the PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and Sinomed databases from database construction until January 2017 for English and Chinese language articles on association of lung cancer and tea drinking. Meta-analysis was used to calculate the combined odds ratio (OR) value and its 95% confidence interval (95% CI). The Newcastle-Ottawa scale was used to evaluate the quality of the studies and Q-test and I2 was used for heterogeneity testing. Results: Forty two papers were included, 30 case-control studies included 14578 lung cancer patients and 180574 controls, 12 cohort studies included 543825 subjects, of which the outcome was 5085 with lung cancer. Tea drinkers were found to have a decreased OR of lung cancer compared with non-tea drinkers (OR 0. 80, 95% CI: 0. 73, 0. 87). Consumption of green, black or unspecified tea has a protective effect compared with not drinking tea at all. Increased intake of green tea to 7. 5 g per day can further reduce the OR of lung cancer (OR 0. 69, 95% CI: 0. 48-0. 98). Tea consumption had a protective effect against lung cancer in non-smokers, Further analysis found that drinking of one or more cups of tea a day has a protective effect on smokers (OR 0. 79, 95%CI: 0. 64–0. 96). Conclusion: Tea drinking could be a protective factor in lung cancer.</jats:p>

Green tea and cancer and cardiometabolic diseases: a review of the current epidemiological evidence

“…Among reproductive organ-related cancers, meta-analyses on endometrial cancer [78] and ovarian cancer reported inverse associations RR = 0.89 (95% CI 0.84-0.94) and RR = 0.64 (95% CI 0.45-0.90), respectively [76]. An inverse association was also found for lung cancer OR = 0.69 (95% CI 0.48-0.82) [58], non-Hodgkins lymphoma RR = 0.61 (95% CI 0.38-0.99) [62] and oral cancer RR = 0.85 (95% CI 0.75-0.93) [64].…”

“…Table 2 reports results from meta-analyses on green tea and cardiovascular-related outcomes [14,21,22,[84][85][86][87]. Three 2 [13,14,22,26,34,40,45,54,58,62,64,65,69,76,78]. Note: Colorectal, lung and pancreatic cancer risk reported as Odds Ratios.…”

“…Fig.2Green tea consumption and overall risk of cancer and cardiovascular disease from recent meta-analyses. References of metaanalyses included in Fig.2[13,14,22,26,34,40,45,54,58,62,64,65,69,76,78]. Note: Colorectal, lung and pancreatic cancer risk reported as Odds Ratios.…”

Health Effects of Soy Isoflavones and Green Tea Catechins on Cancer and Cardiovascular Diseases Based on Urinary Biomarker Levels

“…A comprehensive review by Abe and Inoue [60] showed that most meta-analyses found inverse associations between green tea consumption and endometrial cancer (RR = 0.89; 95% CI = 0.84-0.94) [61], lung cancer (OR = 0.69; 95% CI = 0.48-0.82) [62], non-Hodgkin's lymphoma (RR = 0.61; 95% CI = 0.38-0.99) [63], oral cancer (RR = 0.85; 95% CI = 0.78-0.93) [64], and ovarian cancer (RR = 0.64; 95% CI = 0.45-0.90) [65]. Meanwhile, mixed results were observed in breast, esophageal, gastric, and hepatic cancers.…”

Preventive and therapeutic effects of green tea on lung cancer: a narrative review of evidence from clinical and basic research

“…However, the study design (case-control or cohort) and the sex of the participants can affect the strength of the association between tea consumption and lung cancer risk. In a most recently published meta-analysis ( 11 ), tea consumption was proven to be associated with decreased lung cancer risk (odds ratio 0.80; 95% CI: 0.73–0.87). Consumption of 7.5 g of green tea a day can significantly decrease lung cancer risk, as demonstrated by both case-control studies and cohort studies.…”