Association of lung function with functional limitation in older adults: A cross-sectional study

Gao, Yu Tang; Shen, Liang; Zhan, Runqing; Wang, Xiaoxu; Chen, Huanhuan; Shen, Xiaoli

doi:10.1371/journal.pone.0253606

Cited by 6 publications

(3 citation statements)

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“…In addition, the 6-min walk distance was notably lower in patients with comorbid sarcopenia than in patients without comorbid sarcopenia, and the mMRC score and BODE index was increased in patients with comorbid sarcopenia than in patients without comorbid sarcopenia. Considering that COPD is both an airway and systemic inflammatory disease, a high concentration of inflammatory factors could affect muscle atrophy and decreased muscle function ( 90 , 91 ). A study involving 164 older adults suggested that interleukin-6 levels were negatively associated with skeletal muscle mass index and grip strength, whereas tumor necrosis factor-α and C-reactive protein levels were negatively associated with muscle mass and strength ( 92 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of sarcopenia in patients with COPD through different musculature measurements: An updated meta-analysis and meta-regression

Li²,

Ye³

et al. 2023

Front. Nutr.

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AimChronic obstructive pulmonary disease (COPD) patients vary widely in terms of the prevalence of sarcopenia, which is partially attributed to differences in diagnostic criteria and disease severity. There are several different musculature measurements that are used to quantify sarcopenia. This study included published literature for meta-analysis to assess the sarcopenia prevalence in COPD patients and correlate the disease with the clinical characteristics of such patients.MethodsA comprehensive review of the English and Chinese literature on sarcopenia prevalence in COPD patients was conducted using electronic databases such as China National Knowledge Infrastructure (CNKI), Web of Science, Cochrane Library, EMBASE, PubMed, and Wanfang. Two researchers analyzed the studies for Newcastle-Ottawa Scale. The software Stata 11.0 was employed for the analysis of the acquired data. The standard mean differences method was utilized for the estimation and quantification of the effect size. Furthermore, a fixed- or random-effects model was employed for conducting a combined analysis.ResultsIn total, 56 studies were included as per the specific inclusion criteria. The resulting data of the assessed COPD patients in this research indicated a 27% prevalence of sarcopenia. Further analysis of subgroups was executed per disease severity, ethnicity, diagnostic criteria, gender, and age. Per these findings, increased disease severity elevated the prevalence of sarcopenia. The Latin American and Caucasian populations indicated an increased prevalence of sarcopenia. In addition, the prevalence of sarcopenia was related to diagnostic criteria and definition. Male COPD patients had a higher prevalence of sarcopenia than female COPD patients. COPD patients with an average age greater than 65 had a slightly higher prevalence of sarcopenia. COPD patients with comorbid sarcopenia had poorer pulmonary function, activity tolerance, and clinical symptoms than patients with COPD alone.ConclusionSarcopenia prevalence is high (27%) in COPD patients. In addition, these patients had worse pulmonary function and activity tolerance compared to patients without sarcopenia.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=367422, identifier CRD42022367422.

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Section: Discussionmentioning

confidence: 99%

Prevalence of sarcopenia in patients with COPD through different musculature measurements: An updated meta-analysis and meta-regression

Li²,

Ye³

et al. 2023

Front. Nutr.

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“…Finally, we found that forced vital capacity is also an independent mediator in the relationship between MVPA and FOF. It is highly rational that there is a significant correlation between strenuous MVPA and forced vital capacity, which was found associated with functional performance in older adults ( 42 , 74 , 75 ). However, so far, no study has directly investigated the association between forced vital capacity and FOF in older adults.…”

Section: Discussionmentioning

confidence: 99%

The association between physical activity and fear of falling among community-dwelling older women in China: the mediating role of physical fitness

Shi

et al. 2023

Front. Public Health

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BackgroundThis study aimed to explore the association between physical activity (PA) and fear of falling (FOF) and to determine whether this relationship was mediated by physical fitness (PF) in community-dwelling older women.MethodsFor this cross-sectional study, a total of 1,108 older women were recruited. Moderate-to-vigorous physical activity (MVPA) and light physical activity (LPA) were objectively measured by accelerometers. Physical fitness indicators including body mass index (BMI), forced vital capacity, choice reaction time, grip strength, sit and reach, and five times sit-to-stand were measured. FOF was evaluated by the Chinese version of the activities-specific balance confidence scale. A stepwise linear regression model analysis was used for mediation analysis, and bootstrap analysis was used to verify the mediation effects.ResultThe Pearson correlation coefficient results suggested that MVPA was significantly and negatively correlated with FOF while LPA was not correlated with FOF. Logistic regression analysis suggested a significant association between MVPA, BMI, forced vital capacity, choice reaction time, sit and reach, grip strength, five times sit-to-stand, and FOF. The mediation analysis showed a negative relationship between MVPA and FOF. BMI completely mediated the relationship between MVPA and FOF while sit and reach, five times sit-to-stand, and forced vital capacity partially mediated the relationship between MVPA and FOF.ConclusionAccumulation of more daily MVPA was associated with reducing the odds of FOF in community-dwelling older women. PF indicators fully or partially mediate the relationship between MVPA and FOF. Therefore, more intervention efforts should focus on the promotion of MVPA to improve PF and thus reduce FOF among older women.

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“…An earlier study showed that ~40% of patients with chronic lung diseases were prone to suffer some degree of disability and 68% lost at least one relevant function of daily living ( 22 ). Gao and colleagues also reported that those with poor lung function, as assessed by the FVC < 0.76 criterion, would be at nearly twice the risk of developing functional limitation ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Parecoxib Reduced Postsurgical Pain and Facilitated Movement More Than Patient Controlled Analgesia

et al. 2022

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BackgroundPostoperative pain management is an imperative issue for patients undergoing lumbar spinal fusion surgery. Delayed pain relief is associated with poor clinical outcomes. This study compared the effects of intravenously administered patient-controlled analgesia (PCA) with intravenous parecoxib, both commonly used methods for analgesic pain control after surgery.MethodsA non-randomized study was used to recruit 68 patients who were scheduled to receive lumbar spinal fusion surgery at a hospital in Taiwan from April through December of 2020. The group treated with parecoxib received an initial perioperative dose of parecoxib 40 mg during a 30-min period and then postoperative intravenous parecoxib at 40 mg per 12-h period, for 72 h. Those with PCA received morphine (0.4 mg/ml), droperidol (0.02 mg/ml), diphenhydramine (0.48 mg/ml), midazolam (0.02 mg/ml) and saline solution during the 3-day study course. Major outcomes, including visual scale pain score and Barthel index of activities of daily living, were collected via review of medical records at 4 times: 12, 24, 48 and 72 h after surgery. Comparative effects between two groups were assessed by the generalized estimating equations.ResultsAfter adjusting for potential confounders, the administration of parecoxib was associated with a significant decrease in pain scores and an increase in the Barthel Index, when compared with the PCA group (all p < 0.05). Notably, both effects would maintain for 72 h after surgery.DiscussionThis is the first trial of which the authors are aware, that supports intravenous parecoxib as significantly enhancing patient mobility, in addition to having pain control efficacy, when compared with PCA. This study could be used as a reference when instituting interventions to improve the adaptation process and clinical prognoses after lumbar spinal fusion surgery.

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Association of lung function with functional limitation in older adults: A cross-sectional study

Cited by 6 publications

References 50 publications

Prevalence of sarcopenia in patients with COPD through different musculature measurements: An updated meta-analysis and meta-regression

Prevalence of sarcopenia in patients with COPD through different musculature measurements: An updated meta-analysis and meta-regression

The association between physical activity and fear of falling among community-dwelling older women in China: the mediating role of physical fitness

Parecoxib Reduced Postsurgical Pain and Facilitated Movement More Than Patient Controlled Analgesia

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