Association of lung function with cardiovascular risk: a cohort study

Abstract

BackgroundThe potential effects of pulmonary dysfunction on cardiovascular diseases (CVD) are receiving attention. We aimed to investigate and quantify the cross-sectional and longitudinal associations between lung function and overall cardiovascular risk among Chinese general population.MethodsWe studied 4019 participants from the Wuhan-Zhuhai cohort, with a follow-up of 3 years. A multivariable risk algorithm generated from the Framingham study was used to calculate individuals’ overall cardiovascular risk i.e. 10-Year CVD Risk, which was further classified into 2 categories: low (< 10%) and high (≥10%) CVD risk. General linear model and logistic regression model were separately used to assess the associations of lung function with continuous and dichotomous 10-Year CVD Risk.ResultsCross-sectionally, each 5% decrease in FEV1/FVC was associated with a 0.47% increase in 10-Year CVD Risk (P < 0.001). The adjusted odds ratio (OR) (95% confidence interval [CI]) for the prevalence of high CVD risk (10-Year CVD Risk≥10%) was 1.12 (1.07, 1.17) corresponding to each 5% decrease in FEV1/FVC. The OR (95% CI) for high CVD risk in the lowest group of FEV1/FVC (< 70% i.e. chronic obstructive pulmonary disease [COPD]) was 2.37 (1.43, 3.91) when compared with the highest group. Longitudinally, the adjusted risk ratio (RR) (95% CI) for the incidence of high CVD risk was 1.14 (1.03, 1.25) with each 5% decrease in baseline FEV1/FVC. Compared with the highest group of FEV1/FVC, the RR (95% CI) for high CVD risk in the lowest group (COPD) was 4.06 (1.46, 11.26). Analyses of 10-Year CVD Risk with FVC or FEV1 showed similar trends and significant associations (all P < 0.05).ConclusionReduced lung function was cross-sectionally and longitudinally associated with increased cardiovascular risk in Chinese general population.Electronic supplementary materialThe online version of this article (10.1186/s12931-018-0920-y) contains supplementary material, which is available to authorized users.

Accelerated FEV1decline and risk of cardiovascular disease and mortality in a primary care population of COPD patients

“…It is not fully understood how COPD and CVD are linked beyond their shared risk factors but researchers have identified a number of possible mechanisms such as hypoxia and oxidative stress that might be involved [9,10]. Furthermore, numerous studies have reported the existence of associations between various measures of impaired lung function, including low FEV 1 , FVC and FEV 1 /FVC, and an increased likelihood of developing CVD, as well as an increased risk of hospitalisation and death secondary to CVD [14][15][16][17][18][19][20].…”

C-reactive protein mediates the association between leisure-time physical activity and lung function in middle-aged and older adults

“…The World Health Organization reported that more than 80% of adolescents and 25% of adults are insufficiently physically active (PA) [1]. Lung function such as forced expiratory volume in 1 s (FEV1) or forced vital capacity (FVC) is an important predictor of morbidity of cardiovascular diseases (CVD), type 2 diabetes, cognitive disorders, disability, as well as all-cause mortality [3][4][5][6][7].…”

Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study

“…Besides, lung function impairment also played an important role in the association of asthma with CVD risk 27 , 28 . Long-term airway remodeling in those with asthma, could induce irreversible airway obstruction and lead to lung function impairment.…”