Abstract:Background
Glioma is a highly heterogeneous malignancy with a high mortality rate, poor prognosis. m1A is an RNA methylation modification that plays a vital role in determining cell fate and cell cycle regulation, and cancer development. However, whether single nucleotide polymorphisms (SNPs) of m1A modification genes are associated with glioma risk is unclear.
Methods
We recruited 314 pediatric glioma patients and 380 cancer-free controls from China and genotyped 20 SNPs of m1A modification genes TRMT10C, TRM… Show more
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