Association of male factors with recurrent pregnancy loss

Yu, Wu; Bao, Shihua

doi:10.1016/j.jri.2022.103758

Cited by 4 publications

(4 citation statements)

References 69 publications

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“…Several factors affect RPL such as congenital and anatomical causes, acquired defects, endocrine disorders such as hyperprolactinemia, polycystic ovary syndrome, insulin resistance, untreated diabetes, luteal phase defects in thyroid function, thyroid antibodies, obesity, genetic factors, blood coagulation syndrome ( 55 ). The text-mining analysis found that the etiology of the RPL mainly consists of embryonic karyotype ( 51 ), antiphospholipid syndrome, uterine abnormalities, and abnormal chromosomes ( 57 ), ( 58 ), genetic, anatomical, and infectious factors, auto-immune system abnormalities and endocrine disorders ( 3 ), thrombophilia ( 4 ), male factors ( 3 ), parental chromosomal abnormalities, untreated hypothyroidism, uncontrolled diabetes mellitus, certain uterine anatomic abnormalities, and antiphospholipid antibody syndrome, endocrine disorders, heritable and acquired thrombophilia’s, immunologic abnormalities, infections, and environmental factors ( 59 ). Pre-implantation genetic diagnosis significantly reduced spontaneous abortions ( 60 ).…”

Section: Discussionmentioning

confidence: 99%

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Recurrent Pregnancy Loss: A Bibliometric Review

Panahi,

Akbari,

Ghaemi

2024

ijph

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Background: The research combined different bibliometric techniques to analyze systematically recurrent pregnancy loss (RPL) documents from 1970 to 2023. Methods: Overall, 1287 documents from the Web of Science database associated with recurrent pregnancy loss between 1970 and 2023 were identified for more than 300 journals. The data were analyzed with VOSviewer software. Results: The trend of paying attention to the topic of RPL can be divided into three periods. The number of publications on RPL increased significantly after 2010. Most of the papers were published in Obstetrics and Gynecology and Reproductive Biology areas. Utilizing co-occurrence and co-citation analysis, our study found that the most influential documents mapped the knowledge structure, and projected future research directions. The co-occurrence analysis showed five clusters even though the co-citation analysis designates four. Conclusion: RPL has increased in recent years exponentially and some areas were explained carefully, therefore these results could be used as a research agenda for the future direction by a range of interested beneficiaries.

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Section: Discussionmentioning

confidence: 99%

“…Recurrent pregnancy loss (RPL) is a public, yet indefinable, problem of pregnancy ( 1 ). RPL is defined as two or more pregnancy losses, including embryonic and fetal loss before gestational weeks 20–24 ( 2 ), which bring about important economic and psychological concerns in society ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Recurrent Pregnancy Loss: A Bibliometric Review

Panahi,

Akbari,

Ghaemi

2024

ijph

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“…Генетические маркёры включают в себя аномалии количества и структуры хромосом, микроделеции Y-хромосом, эпигенетические факторы и полимор-Y-хромосом, эпигенетические факторы и полимор--хромосом, эпигенетические факторы и полиморфизмы генов. Негенетические факторы представлены в первую очередь ДНК-фрагментацией сперматозоидов, возрастом отца, отклонениями в параметрах спермограммы и образом жизни (ожирением, курением и наличием хронических заболеваний) [61]. И если генетические факторы непосредственно влияют на риски потери беременности, то роль фрагментации ДНК сперматозоидов остается спорной в связи с отсутствием стандартизированного определения «высокой» фрагментации [62] Изучение негенетических факторов показало относительно более высокое количество провоспалительных цитокинов в семенной плазме мужчин из пар, страдающих привычным выкидышем.…”

Section: мужской фактор невынашивания беременности и роль оксидативно...unclassified

“White spots” in the diagnostic search for the causes of recurrent miscarriage

Lebedenko,

Mikhelson,

Mikhelson

et al. 2024

Med. vestn. Ûga Ross.

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Recurrent pregnancy loss is not only a medical, but also a social problem of a multifactorial nature. This problem remains unsolvable despite the constant search and application of new diagnostic and therapeutic strategies. The presented review examines the literature data on evidence-based methods for diagnosing the causes of miscarriage, as well as methods whose use remains controversial. Special attention is paid to the immunological foundations of a normal pregnancy formation, the violation of which creates the prerequisites for a recurrent miscarriage. The paper also analyzes current data on the role of endometrial receptivity and the contribution of the male factor to the problem of miscarriage, and presents prospects for further research on the problem of recurrent pregnancy loss.

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“…The Royal College of Obstetricians and Gynaecologists has defined RM as three or more spontaneous miscarriages, while the American Society of Reproductive Medicine and the European Society of Human Reproduction and Embryology both defined RM as two or more failures of pregnancy (ESHRE Guideline Group on RPL, 2018; Green & O'Donoghue, 2019; Practice Committee of the American Society for Reproductive Medicine, 2012). The potential etiologies of RM are quite complex and include male factors (such as male partner's sperm quantity, sperm quality, and genetic mutations), and genetic abnormality, anatomic issues, and immune disorders (Deshmukh & Way, 2019; Quenby et al, 2021; Yu & Bao, 2022). Therefore, the treatment of RM also varies greatly and includes surgery, immunotherapies, anticoagulants, endocrine therapies, etc.…”

Section: Introductionmentioning

confidence: 99%

Omega‐3 fatty acid supplements and recurrent miscarriage: A perspective on potential mechanisms and clinical evidence

Huo

Wang

et al. 2023

Food Science & Nutrition

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Recurrent miscarriage (RM) affects approximately 1%–5% of couples worldwide. Due to its complicated etiologies, the treatments for RM also vary greatly, including surgery for anatomic factors such as septate uterus and uterine adhesions, thyroid modulation drugs for hyperthyroidism and hypothyroidism, and aspirin and low molecular weight heparin for antiphospholipid syndrome. However, these treatment modalities are still insufficient to solve RM. Omega‐3 fatty acids are reported to modulate the dysregulation of immune cells, oxidative stress, endocrine disorders, inflammation, etc., which are closely associated with the pathogenesis of RM. However, there is a lack of a systematic description of the involvement of omega‐3 fatty acids in treating RM, and the underlying mechanisms are also not clear. In this review, we sought to determine the potential mechanisms that are highly associated with the pathogenesis of RM and the regulation of omega‐3 fatty acids on these mechanisms. In addition, we also highlighted the direct and indirect clinical evidence of omega‐3 fatty acid supplements to treat RM, which might encourage the application of omega‐3 fatty acids to treat RM, thus improving pregnancy outcomes.

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Association of male factors with recurrent pregnancy loss

Cited by 4 publications

References 69 publications

Recurrent Pregnancy Loss: A Bibliometric Review

Recurrent Pregnancy Loss: A Bibliometric Review

“White spots” in the diagnostic search for the causes of recurrent miscarriage

Omega‐3 fatty acid supplements and recurrent miscarriage: A perspective on potential mechanisms and clinical evidence

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