Aim: The aim of this study was to investigate the effectiveness of Mulligan Mobilization technique in participants with mechanical neck pain. Material and Method: A total of 40 participants (35 female, 5 male) aged between 25 to 50 years were included the study. Participants were randomly divided into two groups as Mulligan Mobilization group and control group. The participants in both groups received home exercise program. The participants were treated 10 times for two weeks. Pain (Visual Analog Scale), muscle strength (stabilizer pressure biofeedback, Hand Held Dynamometer), range of motion (universal goniometer) pain threshold (algometer), disability level (Neck Disability Index), quality of life (Nottingham Health Profile), depressive symptoms (Beck Depression Inventory), cervical performance level (cervical performance tests) were measured at baseline, after the treatment program and repeated 1 month and 3 months after the end of the treatment. Results: In both groups' pain intensity, pain threshold, muscle strength, performance level, the range of motion, disability, depression, and quality of life improved after the treatment program (p<0.05). Discussion: The results of this study showed Mulligan Mobilization treatment program has positive effects on pain, the range of motion, muscle strength, performance level, disability, depressive symptoms, and quality of life in participants with mechanical neck pain.