Association of Marijuana Use With Psychosocial and Quality of Life Outcomes Among Patients With Head and Neck Cancer

Zhang, Han; Xie, Michael; Archibald, Stuart; Jackson, B. Stanley; Gupta, Michael

doi:10.1001/jamaoto.2018.0486

Cited by 43 publications

(47 citation statements)

References 33 publications

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“…Previous studies report conflicting evidence regarding the use of cannabis to improve QoL among oncology patients. 6,7 Our results suggest that, although use is relatively common among patients with CRC, they do not have improved QoL compared to non-users, even after adjusting for baseline factors. Our findings may have differed because we limited our sample to CRC patients, potential confounding by indication (whereby more symptomatic patients were users), and because the tool used to measure outcomes in this study was developed to assess patient-centered outcomes among CRC patients.…”

Section: Discussionmentioning

confidence: 70%

“…4 The role of cannabis to treat pain, 5 reduce cancer-related anorexia, 6 and improve quality of life among patients living with cancer remains inconclusive. 6,7 With legalization of cannabis for medical and recreational use, the number of people using cannabis-containing products is likely to continue to increase. As with any other addictive substance, include alcohol or tobacco, it is important that clinicians inquire about their patients' use of cannabis and to provide evidence-based recommendations to prevent or reduce adverse health effects related to cannabis use.…”

mentioning

confidence: 99%

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A Population-Based Survey to Assess the Association between Cannabis and Quality of Life among Colorectal Cancer Survivors

Calcaterra

Burnett‐Hartman

Powers

et al. 2020

Preprint

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Background: As more states legalize cannabis for medical and recreational use, people increasingly use cannabis to treat medical conditions and associated symptoms. The prevalence and utility of cannabis for cancer-related symptoms may be clarified by examining cannabis use among patients with a common cancer diagnosis. We aimed to determine the prevalence of cannabis use among colorectal cancer (CRC) survivors and its associations with quality of life (QoL) and cancer-related symptomatology.Methods: A cross-sectional survey of patient-reported QoL outcomes and behaviors, including cannabis use, was conducted within the Patient Outcomes To Advance Learning network’s (PORTAL) CRC Cohort. The cohort included a population-based sample of healthcare system members ≥ 18 years old diagnosed with adenocarcinoma of the colon or rectum from 2010 through 2016. We assessed the association between cannabis use and QoL using the European Organization for Research and Treatment of Cancer QLQ-C30 summary score.Results: Of the 1,784 respondents, 293 (16.4%) reported cannabis use following CRC diagnosis. Current tobacco smokers were more likely to use cannabis compared to former or never tobacco smokers (adjusted odds ratio [aOR] 2.71, 95% confidence interval [CI] 1.56 to 4.70). Greater alcohol use (> 4 drinks per month versus ≤ 4 drinks per month) was associated with cannabis use (aOR 2.17, 95% CI 1.65 to 2.85). There was an association between cannabis use and cancer stage at diagnosis, with stage 3 or 4 CRC patients more likely to use cannabis than stage 1 or 2 CRC patients (aOR 1.68, 95% CI 1.25 to 2.25). After adjusting for demographics, medical comorbidities, stage and site of CRC diagnosis, and prescription opioid use, people who used cannabis had significantly lower QoL than people who did not use cannabis (difference of -6.14, 95% CI -8.07 to -4.20). Conclusion: Among CRC survivors, cannabis use was relatively common, associated with more advanced stages of disease, associated with tobacco and alcohol use, and not associated with better QoL. Clinicians should inquire about cannabis use among their patients and provide evidence-based recommendations for cancer-related symptoms.

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Section: Discussionmentioning

confidence: 70%

mentioning

confidence: 99%

A Population-Based Survey to Assess the Association between Cannabis and Quality of Life among Colorectal Cancer Survivors

Calcaterra

Burnett‐Hartman

Powers

et al. 2020

Preprint

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“…Previous studies report conflicting evidence regarding the use of cannabis to improve QoL among oncology patients. 6,7 Our results suggest that, although use is common among patients with CRC, they do not have improved QoL compared to non-users, even after adjusting for baseline factors. Our findings may have differed because we limited our sample to CRC patients, potential confounding by indication (whereby more symptomatic patients were users), and because the tool used to measure outcomes in this study was developed to assess patient-centered outcomes among CRC patients.…”

Section: Discussionmentioning

confidence: 71%

A Population-Based Survey to Assess Cannabis on Quality of Life among Colorectal Cancer Survivors

Calcaterra¹,

Burnett-Hartman²,

Jd³

et al. 2020

Preprint

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Background: As more states legalize cannabis for medical and recreational use, people increasingly use cannabis to treat medical conditions and associated symptoms. The prevalence and utility of cannabis for cancer-related symptoms may be clarified by examining cannabis use among patients with a common cancer diagnosis. We aimed to determine the prevalence of cannabis use among colorectal cancer (CRC) survivors and its associations with quality of life (QoL) and cancer-related symptomatology. Methods: A cross-sectional survey of patient-reported QoL outcomes and behaviors, including cannabis use, was conducted within the Patient Outcomes To Advance Learning network’s (PORTAL) CRC Cohort. The cohort included a population-based sample of healthcare system members ≥ 18 years old diagnosed with adenocarcinoma of the colon or rectum from 2010 through 2016. We assessed the association between cannabis use and QoL using the European Organization for Research and Treatment of Cancer QLQ-C30 summary score. Results: Of the 1,784 respondents, 293 (16.4%) reported cannabis use following CRC diagnosis. Current tobacco smokers were more likely to use cannabis compared to former or never tobacco smokers (adjusted odds ratio [aOR] 2.71, 95% CI 1.56 to 4.70). Greater alcohol use (> 4 drinks per month versus ≤ 4 drinks per month) was associated with cannabis use (aOR 2.17, 95% CI 1.65 to 2.85). There was an association between cannabis use and cancer stage at diagnosis, with stage 3 or 4 CRC patients more likely to use cannabis than stage 1 or 2 CRC patients (aOR 1.68, 95% CI 1.25 to 2.25). After adjusting for demographics, medical comorbidities, stage and site of CRC diagnosis, and prescription opioid use, people who used cannabis had significantly lower QoL than people who did not use cannabis (difference of -6.14, 95% CI -8.07 to -4.20). Conclusion: Among CRC survivors, cannabis use was common, associated with more advanced stages of disease, associated with tobacco and alcohol use, and not associated with better QoL. Clinicians should inquire about cannabis use among their patients and provide evidence-based recommendations for cancer-related symptoms.

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“…In a study from 2018, Zhang et al suggest that cannabis use is associated with significant quality of life benefits, including decreased anxiety, pain, depression, increased appetite and generalized feelings of wellbeing among patients with newly diagnosed HNC [16]. While our study strengthens the theory that cannabis is a non-carcinogenic entity when used recreationally, further research would be beneficial to study the risk of cannabis use on SPC to allow health care providers to accurately advise patients on the risk of cannabis use following HNC treatment.…”

Section: Discussionmentioning

confidence: 99%

Rate of Second Primary Head and Neck Cancer With Cannabis Use

Kim

Hua

Zhang

et al. 2020

Cureus

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Association of Marijuana Use With Psychosocial and Quality of Life Outcomes Among Patients With Head and Neck Cancer

Abstract: This prospective case-matched study suggests that there may be significant QOL benefits, including decreased anxiety, pain, and depression and increased appetite and generalized feelings of well-being, associated with marijuana use among patients with newly diagnosed HNC.

Cited by 43 publications

References 33 publications

A Population-Based Survey to Assess the Association between Cannabis and Quality of Life among Colorectal Cancer Survivors

A Population-Based Survey to Assess the Association between Cannabis and Quality of Life among Colorectal Cancer Survivors

A Population-Based Survey to Assess Cannabis on Quality of Life among Colorectal Cancer Survivors

Rate of Second Primary Head and Neck Cancer With Cannabis Use

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