Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) forced a stoppage in the 2019/2020 season of LaLiga™, possibly influencing performance indicators in the return to competition. Therefore, here, we evaluated whether the stoppage due to the coronavirus 2019 disease (COVID-19) lockdown influenced physical performance compared to the start of LaLigaTM in terms of high-intensity efforts. Using a semi-automatic, multiple-camera system, running activities during 22 matches were analyzed. We compared the first 11 matches of the season (pre-lockdown) with the 11 matches just after the restart of LaLiga™ (post-lockdown). The results showed higher (p < 0.05) performance in the pre-lockdown period compared with the post-lockdown period, including in medium-speed running (14.1–21 km/h), high-speed running (21.1–24 km/h), and sprinting speed running distances (>24 km/h). However, the number of accelerations/min and decelerations/min were significantly higher during the post-lockdown period. Therefore, we conclude that the stoppage due to the COVID-19 lockdown generated lower physical performance in the post-lockdown period compared with the pre-lockdown period, most likely due to the accumulation of matches (congested schedules).