Association of Maternal Dietary Habits and MTHFD1 Gene Polymorphisms With Ventricular Septal Defects in Offspring: A Case-Control Study

Song, Xinli; Liu, Yiping; Wang, Tingting; Zhang, Senmao; Sun, Mengting; Shu, Jing; Wei, Jianhui; Diao, Jingyi; Li, Jinqi; Li, Yihuan; Chen, Letao; Zhu, Ping; Qin, Jiabi

doi:10.3389/fped.2021.785440

Cited by 3 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Song and colleagues aimed at assessing the association between maternal methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) gene polymorphisms, maternal dietary habits in early pregnancy, and their interactions with the risk of ventricular septal defects (VSD) in offspring. By comparing mothers of VSD cases and mothers of healthy infants, they observed significant interaction effects between maternal dietary habits and genetic SNPs of the maternal MTHFD1 gene at rs1950902, rs2236225, and rs2236225 on the risk of VSD [49].…”

Section: Abnormal Embryonic Developmentmentioning

confidence: 99%

Exploring Gene–Diet Interactions for Mother–Child Health: A Systematic Review of Epidemiological Studies

Favara,

Maugeri,

Magnano San Lio

et al. 2024

Nutrients

View full text Add to dashboard Cite

Background: Maternal–child health suggests the critical impact of maternal nutrition during the pre-conception and gestational periods, with some genetic variants also playing a significant role. Our systematic review provides an overview of epidemiological studies exploring the interactions between genetic variants, maternal dietary habits, and neonatal and/or maternal pregnancy outcomes. Methods: From its inception until June 2023, we conducted a comprehensive literature search on PubMed, Embase, and Web of Science databases. Results: On a total of 29 epidemiological studies, 11 studies were conducted to explore the interplay between genetic variants and dietary factors, focusing on the risks associated with gestational diabetes mellitus, hypertensive disorders of pregnancy, recurrent spontaneous abortion, recurrent pregnancy loss, iron deficiency anemia, and gestational weight gain. Concerning neonatal outcomes, six studies investigated the interplay between genetic variants, dietary factors, and anthropometric measures, while eight studies delved into abnormal embryonic development, two studies focused on preterm birth, and two studies explored other neonatal outcomes. Conclusions: Deeply understanding gene–diet interactions could be useful in developing highly personalized approaches to maternal and child nutrition, as well as in exploring the potential implications in disease prevention and the promotion of the long-term well-being of both mothers and their offspring.

show abstract

Section: Abnormal Embryonic Developmentmentioning

confidence: 99%

Exploring Gene–Diet Interactions for Mother–Child Health: A Systematic Review of Epidemiological Studies

Favara,

Maugeri,

Magnano San Lio

et al. 2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…Finally, Song et al ( 380 ) reported that after adjusting for 10 potentially confounding variables, maternal intake during early pregnancy of several foods, one of which was soy, was associated with a reduced risk of ventricular septal defects (VSDs) in the offspring. The highest intake category was consumption ≥6x/wk.…”

Section: Isoflavone-related Topicsmentioning

confidence: 99%

The health effects of soy: A reference guide for health professionals

Messina¹,

Duncan

Messina

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

Soy is a hotly debated and widely discussed topic in the field of nutrition. However, health practitioners may be ill-equipped to counsel clients and patients about the use of soyfoods because of the enormous, and often contradictory, amount of research that has been published over the past 30 years. As interest in plant-based diets increases, there will be increased pressure for practitioners to gain a working knowledge of this area. The purpose of this review is to provide concise literature summaries (400–500 words) along with a short perspective on the current state of knowledge of a wide range of topics related to soy, from the cholesterol-lowering effects of soy protein to the impact of isoflavones on breast cancer risk. In addition to the literature summaries, general background information on soyfoods, soy protein, and isoflavones is provided. This analysis can serve as a tool for health professionals to be used when discussing soyfoods with their clients and patients.

show abstract

Parental genetic effects on the offspring’s phenotype without transmission of the gene itself—pathophysiology and clinical evidence

Zhang,

Hocher

2024

American Journal of Physiology-Cell Physiology

View full text Add to dashboard Cite

Parental genes can influence the phenotype of their offspring through genomic-epigenomic interactions even without the direct inheritance of specific parental genotypes. Maternal genetic variations can affect the ovarian and intrauterine environments and potentially alter lactation behaviors, impacting offspring nutrition and health outcomes independently of the fetal genome. Similarly, paternal genetic changes can affect the endocrine system and vascular functions in the testes, influencing sperm quality and seminal fluid composition. These changes can initiate early epigenetic modifications in sperm, including alterations in microRNAs, tRNA-derived small RNAs, and DNA methylation patterns. These epigenetic modifications might induce further changes in target organs of the offspring, leading to modified gene expression and phenotypic outcomes without transmitting the original parental genetic alterations. This review presents clinical evidence supporting this hypothesis and discusses the potential underlying molecular mechanisms. Parental gene-offspring epigenome-offspring phenotype interactions have been observed in neurocognitive disorders as well as cardio-renal diseases.

show abstract

Association of Maternal Dietary Habits and MTHFD1 Gene Polymorphisms With Ventricular Septal Defects in Offspring: A Case-Control Study

Cited by 3 publications

References 37 publications

Exploring Gene–Diet Interactions for Mother–Child Health: A Systematic Review of Epidemiological Studies

Exploring Gene–Diet Interactions for Mother–Child Health: A Systematic Review of Epidemiological Studies

The health effects of soy: A reference guide for health professionals

Parental genetic effects on the offspring’s phenotype without transmission of the gene itself—pathophysiology and clinical evidence

Contact Info

Product

Resources

About