Association of Maternal History of Spontaneous Abortion and Stillbirth With Risk of Congenital Heart Disease in Offspring of Women With vs Without Type 2 Diabetes

Ji, Honglei; Liang, Hong; Yu, Yongfu; Wang, Ziliang; Yuan, Wei; Qian, Xu; Mikkelsen, Ellen M; Laursen, Anne Sofie Dam; Fang, Guanghong; Huang, Guoying; Miao, Maohua; Li, Jiong

doi:10.1001/jamanetworkopen.2021.33805

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…Evidence regarding VD nutrition and its relationship with all adverse outcomes is controversial. The risk of spontaneous abortion or stillbirth may be associated with multiple complicated factors, including consanguineous marriage [ 70 ], age [ 70 ], BMI [ 71 ], history of chronic disease [ 72 ], passive smoking [ 73 ], and alcohol intake [ 71 ]. Therefore, the benefits of VD supplementation during pregnancy should be evaluated further through rigorous interventional studies.…”

Section: Maternal Vitamin D Status and Adverse Pregnancy Outcomesmentioning

confidence: 99%

Relationship between Maternal Vitamin D Levels and Adverse Outcomes

et al. 2022

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Vitamin D (VD), a fat-soluble vitamin, has a variety of functions that are important for growth and development, including regulation of cell differentiation and apoptosis, immune system development, and brain development. As such, VD status during pregnancy is critical for maternal health, fetal skeletal growth, and optimal pregnancy outcomes. Studies have confirmed that adverse pregnancy outcomes, such as preeclampsia, low birth weight, neonatal hypocalcemia, poor postnatal growth, skeletal fragility, and increased incidence of autoimmune diseases, can be associated with low VD levels during pregnancy and infancy. Thus, there is growing interest in the role of VD during pregnancy. This review summarizes the potential adverse health outcomes of maternal VD status during pregnancy for both mother and offspring (gestational diabetes mellitus, hypertensive gestational hypertension, intrauterine growth restriction, miscarriage, stillbirth, and preterm birth) and discusses the underlying mechanisms (regulation of cytokine pathways, immune system processing, internal secretion, placental function, etc.) of VD in regulating each of the outcomes. This review aims to provide a basis for public health intervention strategies to reduce the incidence of adverse pregnancies.

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Section: Maternal Vitamin D Status and Adverse Pregnancy Outcomesmentioning

confidence: 99%

Relationship between Maternal Vitamin D Levels and Adverse Outcomes

et al. 2022

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“…In 2021, a cohort study of 1,642,534 offspring born in Denmark reported that maternal history of spontaneous abortion were associated with increased risks of overall CHD, and the risk was further enhanced by gestational type 2 diabetes [ 19 ]. A hospital-based study in Southern Israel reported 36% increased risk of CHD after maternal history of recurrent spontaneous abortion (> = 3 times) [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Associated factors for prenatally diagnosed fetal congenital heart diseases

Ruan

Xie

Liu

et al. 2023

BMC Cardiovasc Disord

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Objective Current studies have suggested that fetal congenital heart diseases (CHDs) are caused by various factors. However, few data in this field is available in China. This study aimed to detect associated factors of prenatally diagnosed fetal CHD in a large sample in China. Study design Pregnant women who underwent fetal echocardiography were recruited in our hospital between May 2018 and September 2019. The maternal sociodemographic and lifestyle characteristics and some fetal factors were obtained. We used forward stepwise logistic regression analysis to assess risk of fetal CHD associated with various factors. Results A total of 5024 subjects were enrolled, of whom 875 had CHD fetuses. Among the fetal CHD group (N = 875), critical CHDs account for 27%, of which Tetralogy of Fallot is the most (7.1%), followed by coarctation of aorta (4.0%), double-outlet right ventricle (2.9%). The forward stepwise logistic regression models revealed that history of spontaneous abortion (OR = 1.59, 95% CI 1.33–1.91, P = 0.000), upper respiratory tract infection during early pregnancy (OR = 1.30, 95% CI 1.04–1.62, P = 0.020), mental stress during early pregnancy (OR = 2.37, 95% CI 1.15–4.91, P = 0.020), single umbilical artery (OR = 2.30, 95% CI 1.18–4.51, P = 0.015), and paternal smoking (OR = 1.21, 95% CI 1.02–1.44, P = 0.027) are positively associated with an increased risk of fetal CHD. Conclusion We identified several factors positively associated with fetal CHD. These findings suggest that it is important to strengthen healthcare and prenatal counseling for women with these factors.

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“…According to retrospective studies, PGDM was reported to be highly associated with congenital heart diseases (CHDs) ( 52 – 56 ) and fetal diastolic dysfunction ( 58 ). Even in non-diabetic pregnant women, an elevated glucose level in the first trimester was directly correlated with an increased risk of CHD in the offspring ( 57 ).…”

Section: The Adverse Effects Of Maternal Diabetes On Offspringmentioning

confidence: 99%

Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia

Yan

Feng

et al. 2023

Front. Nutr.

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Diabetes mellitus during pregnancy, which can be classified into pregestational diabetes and gestational diabetes, has become much more prevalent worldwide. Maternal diabetes fosters an intrauterine abnormal environment for fetus, which not only influences pregnancy outcomes, but also leads to fetal anomaly and development of diseases in later life, such as metabolic and cardiovascular diseases, neuropsychiatric outcomes, reproduction malformation, and immune dysfunction. The underlying mechanisms are comprehensive and ambiguous, which mainly focus on microbiota, inflammation, reactive oxygen species, cell viability, and epigenetics. This review concluded with the influence of intrauterine hyperglycemia on fetal structure development and organ function on later life and outlined potential mechanisms that underpin the development of diseases in adulthood. Maternal diabetes leaves an effect that continues generations after generations through gametes, thus more attention should be paid to the prevention and treatment of diabetes to rescue the pathological attacks of maternal diabetes from the offspring.

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Association of Maternal History of Spontaneous Abortion and Stillbirth With Risk of Congenital Heart Disease in Offspring of Women With vs Without Type 2 Diabetes

Abstract: IMPORTANCEThe associations of maternal history of spontaneous abortion (SA) and stillbirth with congenital heart disease (CHD) remain elusive. OBJECTIVE To evaluate the associations of maternal history of pregnancy loss with CHD in offspring and the role of maternal type 2 diabetes.

Cited by 5 publications

References 36 publications

Relationship between Maternal Vitamin D Levels and Adverse Outcomes

Relationship between Maternal Vitamin D Levels and Adverse Outcomes

Associated factors for prenatally diagnosed fetal congenital heart diseases

Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia

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