Association of maternal iron deficiency anemia with the risk of gestational diabetes mellitus: a meta-analysis

Tiongco, Raphael Enrique; Arceo, Engracia; Clemente, Benjie; Pineda-Cortel, Maria Ruth

doi:10.1007/s00404-018-4932-0

Cited by 18 publications

(18 citation statements)

References 48 publications

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“…Others suggest that iron overload can be toxic to β-cells and thereby influence insulin secretion [33]. It has been speculated that the association between anaemia and increased risk for GDM may be explained by a more general nutritional status including micronutrient deficiency among women with GDM [31]. However, most women in our study had normal levels of folic acid and vitamin B12.…”

Section: Discussionmentioning

confidence: 55%

“…In the present study, no associations (except for a weak association between Hb at inclusion and fasting glucose from the OGTT after adjustment for age and BMI) between Hb or ferritin levels and glucose concentrations were found. Previous studies have suggested that anaemia in pregnancy increases the risk of GDM [9,30] whereas a recent meta-analysis based on six studies, reported that pregnant women with iron-deficiency anaemia were 39% less likely to develop GDM [31]. These discrepancies may be due to differences in study populations, diagnosis of GDM and timing of Hb and ferritin measurements.…”

Section: Discussionmentioning

confidence: 96%

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High Prevalence of Gestational Diabetes Mellitus in Rural Tanzania—Diagnosis Mainly Based on Fasting Blood Glucose from Oral Glucose Tolerance Test

Grunnet

Hjort

Minja

et al. 2020

IJERPH

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Gestational diabetes mellitus (GDM) is associated with poor pregnancy outcomes and increased long-term risk of metabolic diseases for both mother and child. In Tanzania, GDM prevalence increased from 0% in 1991 to 19.5% in 2016. Anaemia has been proposed to precipitate the pathogenesis of GDM. We aimed to examine the prevalence of GDM in a rural area of Tanzania with a high prevalence of anaemia and to examine a potential association between haemoglobin concentration and blood glucose during pregnancy. The participants were included in a population-based preconception, pregnancy and birth cohort study. In total, 538 women were followed during pregnancy and scheduled for an oral glucose tolerance test (OGTT) at week 32–34 of gestation. Gestational diabetes mellitus was diagnosed according to the WHO 2013 guidelines. Out of 392 women screened, 39% (95% CI: 34.2–44.1) had GDM, the majority of whom (94.1%) were diagnosed based solely on the fasting blood sample from the OGTT. No associations were observed between haemoglobin or ferritin and glucose measurements during pregnancy. A very high prevalence of GDM was found in rural Tanzania. In view of the laborious, costly and inconvenient OGTT, alternative methods such as fasting blood glucose should be considered when screening for GDM in low- and middle-income countries.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 96%

High Prevalence of Gestational Diabetes Mellitus in Rural Tanzania—Diagnosis Mainly Based on Fasting Blood Glucose from Oral Glucose Tolerance Test

Grunnet

Hjort

Minja

et al. 2020

IJERPH

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show abstract

“…During the survey, we were somewhat astonished to note that multiple pregnant women never prefer to consume animal entrails before pregnancy, which may be one of the reasons why the participants had such a severe iron-rich food deficiency during pregnancy. Since iron-rich food deficiency is related to premature, postpartum hemorrhage, and low birth weight, it is indispensable to augment the intake of ironrich foods during pregnancy [29,30]. Besides, soybean and its products, aquatic products, milk and milk products, eggs, and meats are generally considered favorable sources of high-quality protein and minerals, yet more than 60% of participants did not meet the recommended intake.…”

Section: Discussionmentioning

confidence: 99%

Association between maternal dietary quality and gestational diabetes mellitus based on the Diet Balance Index for Pregnancy

Wang¹,

Wang²,

Luo³

et al. 2021

Preprint

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Background: Maternal diet is critical to the development of gestational diabetes mellitus (GDM), but sparse studies have applied the Chinese Dietary Balance Index for Pregnancy (DBI-P) to assess the maternal dietary quality and its relationship with GDM. We aimed to examine the maternal dietary quality and its relationship with GDM risk using the newly developed DBI-P. Methods: We included 1122 pregnant women from the Tongji Birth Cohort (TJBC) in Wuhan, China. The semi-quantitative food frequency questionnaire (FFQ) was used to obtain the dietary information during pregnancy. The newly developed DBI-P, including DBI-P components and DBI-P dietary patterns, was applied to comprehensively evaluate the maternal dietary quality. GDM was diagnosed by the 75-g, 2-h oral glucose tolerance test at 24-28 weeks gestation. We used a generalized linear regression model to examine the relationship between DBI-P components and blood glucose levels, and a logistic regression model to examine the relationship between dietary patterns and GDM. Results: A total of 179 participants (16.0%) were diagnosed with GDM. There is a widespread phenomenon of dietary imbalance among pregnant women in Wuhan. With per score increase in nuts and eggs, fasting blood glucose increase by 0.03 mmol/l (95% CI: 0.01, 0.05) and 0.01 mmol/l (95 %CI: 0.01, 0.03), respectively, while per score increase in fruits, 1-h post-load blood glucose decreased by 0.05 mmol/l (95% CI: -0.10, -0.01). Besides, compared with pattern E characterized by higher intake of total energy, total fat, fruits, and cooking oil, pattern B (OR: 0.51, 95% CI: 0.26, 0.99) and pattern C (OR: 0.27, 95% CI: 0.09, 0.81) were associated with a lower GDM risk. The associations between dietary patterns and GDM risk may be partly attributed to the intakes of dietary total fat, carbohydrate, cholesterol, eggs, and cooking oil. Conclusions: Unfavorable dietary quality during pregnancy is associated with a higher risk of GDM. The newly established DBI-P can provide an easy-to-implement tool to assess maternal dietary quality. These findings will provide new insights for the exploration of preferable dietary evaluation methods and prevention and control of GDM.

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“…The association of iron deficiency with diabetes is less clear. A large meta-analysis suggested that pregnant women with iron deficiency anemia have less risk of developing gestational diabetes [166]. In a recent study in mice iron deficiency impaired insulin secretion and caused diabetes [167].…”

Section: Environmental Factors Affecting Trna Aminoacylation Modificmentioning

confidence: 99%

tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors

Arroyo

Green²,

Cnop³

et al. 2021

IJMS

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The global rise in type 2 diabetes results from a combination of genetic predisposition with environmental assaults that negatively affect insulin action in peripheral tissues and impair pancreatic β-cell function and survival. Nongenetic heritability of metabolic traits may be an important contributor to the diabetes epidemic. Transfer RNAs (tRNAs) are noncoding RNA molecules that play a crucial role in protein synthesis. tRNAs also have noncanonical functions through which they control a variety of biological processes. Genetic and environmental effects on tRNAs have emerged as novel contributors to the pathogenesis of diabetes. Indeed, altered tRNA aminoacylation, modification, and fragmentation are associated with β-cell failure, obesity, and insulin resistance. Moreover, diet-induced tRNA fragments have been linked with intergenerational inheritance of metabolic traits. Here, we provide a comprehensive review of how perturbations in tRNA biology play a role in the pathogenesis of monogenic and type 2 diabetes.

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Association of maternal iron deficiency anemia with the risk of gestational diabetes mellitus: a meta-analysis

Cited by 18 publications

References 48 publications

High Prevalence of Gestational Diabetes Mellitus in Rural Tanzania—Diagnosis Mainly Based on Fasting Blood Glucose from Oral Glucose Tolerance Test

High Prevalence of Gestational Diabetes Mellitus in Rural Tanzania—Diagnosis Mainly Based on Fasting Blood Glucose from Oral Glucose Tolerance Test

Association between maternal dietary quality and gestational diabetes mellitus based on the Diet Balance Index for Pregnancy

tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors

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