Association of maternal ozone exposure with term low birth weight and susceptible window identification

Wang, Qiong; Miao, Huazhang; Warren, Joshua L.; Ren, Meng; Benmarhnia, Tarik; Knibbs, Luke D.; Zhang, Huanhuan; Zhao, Qingguo; Huang, Cunrui

doi:10.1016/j.envint.2020.106208

Cited by 35 publications

(18 citation statements)

References 42 publications

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“…There are several possible biologic mechanisms through which ambient air pollution can cause LBW ( 32 , 33 ). Yet, no studies have specifically focused on the mechanisms that cause very low birth weight.…”

Section: Discussionmentioning

confidence: 99%

Associations between maternal exposure to ambient air pollution and very low birth weight: A birth cohort study in Chongqing, China

Zhou

Ming²,

Yang³

et al. 2023

Front. Public Health

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IntroductionThere have been many researches done on the association between maternal exposure to ambient air pollution and adverse pregnancy outcomes, but few studies related to very low birth weight (VLBW). This study thus explores the association between maternal exposure to ambient air pollutants and the risk of VLBW, and estimates the sensitive exposure time window.MethodsA retrospective cohort study analyzed in Chongqing, China, during 2015–2020. The Generalized Additive Model were applied to estimate exposures for each participant during each trimester and the entire pregnancy period.ResultsFor each 10 μg/m3 increase in PM2.5 during pregnancy, the relative risk of VLBW increased on the first trimester, with RR = 1.100 (95% CI: 1.012, 1.195) in the single-pollutant model. Similarly, for each 10 μg/m3 increase in PM10, there was a 12.9% (RR = 1.129, 95% CI: 1.055, 1.209) increase for VLBW on the first trimester in the single-pollutant model, and an 11.5% (RR = 1.115, 95% CI: 1.024, 1.213) increase in the multi-pollutant model, respectively. The first and second trimester exposures of NO2 were found to have statistically significant RR values for VLBW. The RR values on the first trimester were 1.131 (95% CI: 1.037, 1.233) and 1.112 (95% CI: 1.015, 1.218) in the single-pollutant model and multi-pollutant model, respectively; The RR values on the second trimester were 1.129 (95% CI: 1.027, 1.241) and 1.146 (95% CI: 1.038, 1.265) in the single-pollutant model and multi-pollutant model, respectively. The RR of O3 exposure for VLBW on the entire trimester was 1.076 (95% CI: 1.010–1.146), and on the second trimester was 1.078 (95% CI: 1:016, 1.144) in the single-pollutant model.ConclusionThis study indicates that maternal exposure to high levels of PM2.5, PM10, NO2, and O3 during pregnancy may increase the risk of very low birth weight, especially for exposure on the first and second trimester. Reducing the risk of early maternal exposure to ambient air pollution is thus necessary for pregnant women.

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Section: Discussionmentioning

confidence: 99%

Associations between maternal exposure to ambient air pollution and very low birth weight: A birth cohort study in Chongqing, China

Zhou

Ming²,

Yang³

et al. 2023

Front. Public Health

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“…To identify the window of susceptibility for exposure, distributed lag models were applied to estimate the associations between HDP (gestational hypertension and preeclampsia) risk and weekly O 3 exposures, reducing the role of collinearity in O 3 exposures during other weeks by creating a flexible cross-basis function. 31 Natural cubic spline functions with 3 degrees of freedom were assigned to the exposure variable in the value and lag dimensions.…”

Section: Methodsmentioning

confidence: 99%

Ozone Exposure During Pregnancy and Risk of Gestational Hypertension or Preeclampsia in China

et al. 2023

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ImportanceAlthough certain air pollutants have been associated with adverse obstetric outcomes, evidence regarding the association of ozone (O3) exposure with the risk of hypertensive disorders in pregnancy (HDP) is limited and inconsistent.ObjectivesTo evaluate the association between gestational O3 exposure and HDP (ie, gestational hypertension and preeclampsia) risk, and to explore the window of susceptibility for O3 exposure during pregnancy.Design, Setting, and ParticipantsThis cohort study recruited pregnant patients from the Obstetrics and Gynecology Hospital of Fudan University in Shanghai, China, from March 2017 to December 2018. Participants were older than 18 years, had no infectious diseases or chronic noncommunicable diseases before pregnancy, were Shanghai residents with intent to participate in the study, and had plans to give birth in Shanghai. Gestational hypertension and preeclampsia were diagnosed according to the diagnostic criteria of the Chinese Society of Obstetrics and Gynecology during the study period. Data on residential addresses, demographic characteristics, and household living environments were collected from participants through a questionnaire survey. Data were analyzed from December 10, 2021, to May 10, 2022.ExposuresA high temporospatial resolution model was applied to predict individual levels of daily O3 exposure during pregnancy.Main Outcomes and MeasuresThe outcomes were gestational hypertension and preeclampsia, and data on these diagnoses were extracted from the hospital’s information system. A logistic regression model was used to estimate the associations between O3 exposure and risk of gestational hypertension or preeclampsia. Exposure-response associations were confirmed by restricted cubic spline functions. Distributed lag models were used to identify the O3 exposure window of susceptibility.ResultsAmong the 7841 participants (all females; mean [SD] age, 30.4 [3.8] years), 255 (3.2%) had gestational hypertension and 406 (5.2%) had preeclampsia. Pregnant individuals with HDP had considerably higher prepregnancy body mass indexes and lower educational levels. The mean (SD) O3 exposure levels were 97.66 (25.71) μg/m3 in the first trimester and 106.13 (22.13) μg/m3 in the second trimester. Each 10-μg/m3 increment of O3 exposure during the first trimester was associated with higher gestational hypertension risk (relative risk, 1.28; 95% CI, 1.04-1.57). However, gestational O3 exposure was not associated with the risk of preeclampsia. The restricted cubic spline function analysis revealed an exposure-response association between O3 exposure and risk of gestational hypertension.Conclusions and RelevanceResults of this study showed an association between increased gestational hypertension risk and O3 exposure during the first trimester. Furthermore, gestational weeks 1 to 9 were identified as the window of susceptibility for O3 exposure and elevated gestational hypertension risk. Sustainable O3 control is needed to reduce the disease burden of gestational hypertension.

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“…As a common complication of twin pregnancies, twin growth discordance affects nearly 16% of twins . Although ozone has been suggested as a potential risk factor of low birth weight among singletons, ,− to our knowledge, the impact of maternal ozone exposure on twin growth discordance has not been quantified.…”

Section: Introductionmentioning

confidence: 96%

Evaluating the Impact of Maternal Exposure to Ozone on Twin Fetal Growth in China

Shen,

Zhang,

et al. 2023

Environ. Sci. Technol.

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Association of maternal ozone exposure with term low birth weight and susceptible window identification

Cited by 35 publications

References 42 publications

Associations between maternal exposure to ambient air pollution and very low birth weight: A birth cohort study in Chongqing, China

Associations between maternal exposure to ambient air pollution and very low birth weight: A birth cohort study in Chongqing, China

Ozone Exposure During Pregnancy and Risk of Gestational Hypertension or Preeclampsia in China

Evaluating the Impact of Maternal Exposure to Ozone on Twin Fetal Growth in China

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