Association of Maternal Plasma Manganese with the Risk of Spontaneous Preterm Birth: A Nested Case–Control Study Based on the Beijing Birth Cohort Study (BBCS) in China

Han, Weiling; Zheng, Wei; Wang, Aili; Chen, Junxi; Wang, Jia; Huang, Junhua; An, Hang; Ma, Yuru; Zhang, Kexin; Yang, Rui; Yan, Lailai; Li, Zhiwen; Li, Guanghui

doi:10.3390/nu15061413

Cited by 5 publications

(1 citation statement)

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“…A nested case–control study was conducted based on a prospective maternal and child health cohort, the Beijing Birth Cohort Study (BBCS, ChiCTR2200058395), from 2017 to 2018 in Beijing, China. The inclusive criteria have been described in a previous study [ 25 ]. Briefly, pregnant women were recruited if they met the following criteria: aged 18–44, with gestational week <14 weeks at their first visit for prenatal examination, with a written informed consent, and women who planned to accept routine prenatal examinations and delivery at Beijing Obstetrics and Gynecology Hospital.…”

Section: Materials/subjects and Methodsmentioning

confidence: 99%

Butyrate and iso-butyrate: a new perspective on nutrition prevention of gestational diabetes mellitus

Han,

Wang,

Yan

et al. 2024

Nutr. Diabetes

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Background Dietary imbalance, such as a lower proportion of complex carbohydrates and a higher protein diet, may contribute to gestational diabetes mellitus (GDM) risks through their metabolisms. However, there is a lack of knowledge regarding the association between butyrate, iso-butyrate, and GDM, which are metabolisms of the two primary nutrients above. This study aimed to clarify the association of butyrate and iso-butyrate with GDM. Methods A nested case–control study was conducted based on the Beijing Birth Cohort Study (BBCS) from 2017 to 2018. Totally, 99 singleton women were involved (GDM: n = 49, control: n = 50). All participants provided blood samples twice (in their first and second trimesters). Gas chromatography-mass spectrometry (GC-MS) was used for butyrate and iso-butyrate detection. Unconditional logistic regression and receiver operating characteristic (ROC) curve analysis were used for statistical analysis. Results The results showed that butyrate in the first trimester was negatively correlated with GDM (odds ratio (OR): 0.00, 95% confidential interval (CI): 0.00–0.21, P = 0.008), and iso-butyrate in the second trimester was positively related to GDM (OR: 627.68, 95% CI: 40.51–9724.56, P < 0.001). The ratio (butyrate/iso-butyrate) was negatively associated with GDM, both in the first trimester (OR: 0.00, 95%CI: 0.00–0.05, P < 0.001) and in the second trimester (OR: 0.52, 95% CI: 0.34–0.80, P = 0.003). The area under the curve (AUC) using the ratio in the first trimester combined with clinical risk factors achieved 0.89 (95% CI: 0.83–0.95). Iso-butyrate in the second trimester combined with clinical risk factors achieved an AUC of 0.97 (95% CI: 0.92–1.00). Conclusions High iso-butyrate and low butyrate levels may be associated with an increased risk of GDM. As they are produced through dietary nutrient formation by gut microbiota, further studies on the association of dietary intake and butyrate or iso-butyrate concentration in plasma may help find a novel approach to nutritional intervention for GDM.

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Section: Materials/subjects and Methodsmentioning

confidence: 99%