Association of Maternal Preeclampsia with Neonatal Respiratory Distress Syndrome in Very-Low-Birth-Weight Infants

Wen, Yang; Yang, Hwai I.; Chou, Hung-Chieh; Chen, Chien-Yi; Hsieh, Wu‐Shiun; Yau, Kuo-Inn Tsou; Tsao, Po‐Nien

doi:10.1038/s41598-019-49561-8

Cited by 35 publications

(29 citation statements)

References 41 publications

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“…In our study, we observed PIH in 16% of mothers of VLBH neonates which was lower as compared to the previous results [33]. RDS occurred in 34% of VLBW neonates in the current study which was low as compared to a recent study done by Wen et al [34] in 2019 who observed the incidence of 86% and that of severe RDS as 41.2%. In the current study, apnea observed was comparatively less with 11% of the VLBW neonates affected, whereas, in a study done by Zhao et al [35], it was around 54%.…”

Section: Discussioncontrasting

confidence: 83%

Morbidities and mortalities in very low birth weight newborn a cohort study at tertiary care center of Central India

Mehar¹,

Muley²,

Agrawal³

et al. 2020

Indian J Child Health

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ery low birth weight (VLBW) neonates represent a vulnerable group of newborns with a high mortality rate. The survival in neonates is associated with their birth weights, gestation, and illness severity. The survival rate of VLBW infants varies globally with 40% in developing countries to more than 90% in developed countries [1]. VLBW neonates who survived tend to have a higher risk for neurodevelopmental disabilities causing significant changes to the lives of their families [2]. Varied morbidities have been associated during initial hospitalization of VLBW infants, including respiratory distress syndrome (RDS), bloodstream and central nervous system infections, necrotizing enterocolitis (NEC), chronic lung disease (CLD), intraventricular hemorrhage, periventricular leukomalacia, and retinopathy of prematurity, leading to exposure to additional diagnostic, therapeutic, and surgical interventions. These cause psychological distress to families with an increase in the length of hospital stay, the risk of recurrent hospitalization, and costs of treatment [3].The morbidities in infants are proved to be associated with neurodevelopmental disabilities developing later including cerebral palsy, cognitive delay, hearing loss, and visual impairment [4,5]. According to several studies performed about morbidity and mortality and morbidity of neonates in the past two decades, no additional improvements have been seen [6]. Data are scarce on the incidence of short-term morbidities in preterm neonates from India. Bhat and Adhisivam concluded that early weaning from mechanical ventilator support in VLBW infants reduced morbidities such as CLD and infections [7]. The present study was designed and executed to assess the short-term outcomes of neonates with birth weights between 1000 g and 1500 g treated at the tertiary hospital of Central India. MATERIALS AND METHODSThis prospective cohort study was conducted in the NICU, conducted at the tertiary hospital of Central India from April 2014 to March 2015. It was a level 3 NICU with 20 intensive care beds and 6 bedded kangaroo mother care (KMC) ward with an annual admission of more than 1000 cases. All live VLBW neonates (1000-1500 g), admitted between the study period, were enrolled for the study. Extremely low weight (<1000 g), low birth weight (1500-2500 g), and normal birth weight (>2500 g) neonates

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Section: Discussioncontrasting

confidence: 83%

Morbidities and mortalities in very low birth weight newborn a cohort study at tertiary care center of Central India

Mehar¹,

Muley²,

Agrawal³

et al. 2020

Indian J Child Health

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“…Decreased utero-placental perfusion also significantly increases the risk of intrauterine growth restriction, preterm birth and other neonatal comorbidities (like respiratory distress syndrome, intraventricular hemorrhage) and other systemic disturbances [21,22]. In addition, these children are more susceptible to neurodevelopmental and behavioral problems as well as chronic noncommunicable disease later in life [12,23,24].…”

Section: Introductionmentioning

confidence: 99%

The impact of pregnancy induced hypertension on low birth weight in Ethiopia: systematic review and meta-analysis

2020

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Background Even though neonatal mortality reduction is the major goal needed to be achieved by 2030, it is still unacceptably high especially in Ethiopia. In the other hand, low birth weight is the major cause of neonatal mortality and morbidity. More than 10 millions of low birth weight infants occurred as a result of pregnancy induced hypertension. However, in Ethiopia the association between low birth weight and pregnancy induced hypertension was represented with un-updated, inconclusive and different studies. Therefore, this review aimed to estimate the overall pooled impact of pregnancy induced hypertension on low birth weight and its association in Ethiopia. Methods articles searched on PubMed/Medline, EMBASE, CINAHL, Cochrane library, Google, Google Scholar and local shelves. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument (JBI-MAStARI) was applied for critical appraisal. The I2 statistic was computed to check the presence of heterogeneity. Publication bias was evaluated using funnel plot asymmetry and Egger’s test. A random effect model was used to estimate the pooled prevalence of low birth weight. Result From the total 131 identified original articles, 25 were eligible and included for the final analysis. The overall pooled prevalence of low birth weight among women who had pregnancy induced hypertension in Ethiopia was 39.7% (95% CI: 33.3, 46.2). But, I2 statistic estimation evidenced significant heterogeneity across included studies (I2 = 89.4, p < 0.001). In addition, the odds of having low birth weight newborns among women who had pregnancy induced hypertension was 3.89 times higher compared to their counterparts (OR = 3.89, 95% CI: 2.66, 5.69). Conclusion The pooled prevalence of low birth weight among women who had pregnancy induced hypertension was more than two times higher than the pooled estimate of low birth weight among all reproductive aged women. The odds of low birth weight also increased nearly four times among women with pregnancy induced hypertension than normotensive women. Therefore, health policies which provide better and quality antenatal care with more oriented on importance of early detection and management of pregnancy induced hypertension should be implemented.

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“…In this study, neonates of hypertensive mothers had a higher risk of the need for MV within 72 h after extubation than those of normotensive mothers. It has been shown that gestational hypertension can promote maternal production of soluble fms-like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor that can block vascular endothelial growth factor (VEGF) signaling [ 26 , 27 ]. Since VEGF signaling is essential for the growth of pulmonary blood vessels and the production of surfactants, sFlt-1 may lead to increased incidence and severity of RDS in preterm neonates with hypertensive mothers.…”

Section: Discussionmentioning

confidence: 99%

Lung recruitment improves the efficacy of intubation-surfactant-extubation treatment for respiratory distress syndrome in preterm neonates, a randomized controlled trial

et al. 2022

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Background Lung recruitment is a maneuver used to decrease the length of intubation in preterm neonates. This study aimed to compare the therapeutic efficacy of lung recruitment plus intubation-surfactant-extubation (INSURE) procedure and INSURE alone for the preterm neonates with respiratory distress syndrome. Methods From 2017 to 2019, 184 preterm neonates (gestational age 24–32 weeks) with respiratory distress syndrome were enrolled and randomized into the lung recruitment group receiving lung recruitment (25 cm H2O, 15 s) plus INSURE and the control group receiving INSURE only. The primary outcome was the need for mechanical ventilation (MV) within 72 h after extubation. The secondary outcomes included duration of MV, noninvasive ventilation, total oxygen therapy, hospitalization time, and complications. Results Compared to the control group, the lung recruitment group had a significantly lower proportion of preterm neonates requiring MV within 72 h after extubation (23% vs. 38%, P = 0.025) and pulmonary surfactant administration, as well as a shorter MV duration. There was no significant difference in the incidences of complications (all P > 0.05) and in-hospital mortality (2% vs. 4%, P = 0.4) between the lung recruitment group and control group. Multivariate logistic regression analysis demonstrated that the control group had a 2.17-time higher risk of requiring MV than the lung recruitment group (AOR: 2.17, 95% CI: 1.13–4.18; P = 0.021). Compared with infants with a normotensive mother, infants with a hypertensive mother have a 2.41-time higher risk of requiring MV (AOR: 2.41, 95% CI: 1.15–5.05; P = 0.020). Conclusion Lung recruitment plus INSURE can reduce the need for MV within 72 h after extubation and did not increase the incidence of complications and mortality. Trial registration Chinese Clinical Trial Registry ChiCTR1800020125, retrospectively registered on December 15, 2018.

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Association of Maternal Preeclampsia with Neonatal Respiratory Distress Syndrome in Very-Low-Birth-Weight Infants

Cited by 35 publications

References 41 publications

Morbidities and mortalities in very low birth weight newborn a cohort study at tertiary care center of Central India

Morbidities and mortalities in very low birth weight newborn a cohort study at tertiary care center of Central India

The impact of pregnancy induced hypertension on low birth weight in Ethiopia: systematic review and meta-analysis

Lung recruitment improves the efficacy of intubation-surfactant-extubation treatment for respiratory distress syndrome in preterm neonates, a randomized controlled trial

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