Association of maternal prenatal urinary fluoride levels with ADHD symptoms in childhood.

Ibarluzea, Jesús; Subiza-Pérez, Mikel; Arregi, Ane; Molinuevo, Amaia; Arranz-Freijo, Enrique B.; Miguél, Manuel Sánchez de; Jiménez, Ana; Andiarena, Ainara; Santa‐Marina, Loreto; Lertxundi, Aitana

doi:10.1016/j.envres.2023.116705

Cited by 3 publications

(3 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Still, when considering the global body of scientific literature, there are some inconsistencies. [32][33][34] It is well-established that the prenatal and early postnatal periods are windows of susceptibility for neurodevelopmental impacts of environmental toxicant exposures. 35,36 Animal studies have delineated potential mechanisms underlying the association of prenatal fluoride exposure with neurobehavioral development.…”

Section: Discussionmentioning

confidence: 99%

“…Taken together, the weight of the scientific literature supports an association of prenatal fluoride exposure with adverse child cognitive and neurobehavioral development in North America. Still, when considering the global body of scientific literature, there are some inconsistencies …”

Section: Discussionmentioning

confidence: 99%

“…Still, when considering the global body of scientific literature, there are some inconsistencies. 32 , 33 , 34 …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal Urinary Fluoride and Child Neurobehavior at Age 36 Months

Malin,

Eckel,

et al. 2024

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceRecent studies in Canadian and Mexican populations suggest an association of higher prenatal fluoride exposure with poorer neurobehavioral development, but whether this association holds for US-based populations is unknown.ObjectiveTo examine associations of third trimester maternal urinary fluoride (MUF) with child neurobehavior at age 3 years in the US.Design, Setting, and ParticipantsThis prospective cohort study utilized urine samples archived from 2017 to 2020 and neurobehavioral data assessed from 2020 to 2023 from the Maternal and Developmental Risks from Environmental and Social Stressors (MADRES) pregnancy cohort, which consisted of predominately Hispanic women residing in Los Angeles, California. Cohort eligibility criteria at recruitment included being 18 years of age or older, less than 30 weeks’ gestation, and a fluent English or Spanish speaker. Exclusion criteria included having a disability preventing participation or provision of informed consent, being HIV positive or incarcerated, and having a multiple gestation pregnancy. There were 263 mother-child pairs who completed the 3-year study visit. In this analysis, women who reported prenatal smoking were excluded. Data analysis was conducted from October 2022 to March 2024.ExposureSpecific gravity-adjusted MUF (MUFSG), a biomarker of prenatal fluoride exposure.Main Outcomes and MeasuresNeurobehavior was quantified using the Preschool Child Behavior Checklist (CBCL), which included composite scores for Total Problems, Internalizing Problems, and Externalizing Problems. CBCL composite T scores range from 28 to 100. T scores from 60 to 63 are in the borderline clinical range, whereas scores above 63 are in the clinical range. Linear and logistic regression models adjusted for covariates were conducted.ResultsA total of 229 mother-child pairs (mean [SD] maternal age, 29.45 [5.67] years; 116 female children [50.7%] and 113 male children [49.3%]) who had MUFSG measured were included in the study. Median (IQR) MUFSG was 0.76 (0.51-1.19) mg/L, and 32 participants (14.0%) had a Total Problems T score in the borderline clinical or clinical range. A 1-IQR (0.68 mg/L) increase in MUFSG was associated with nearly double the odds of the Total Problems T score being in the borderline clinical or clinical range (odds ratio, 1.83; 95% CI, 1.17-2.86; P = .008), as well as with a 2.29-point increase in T score for the Internalizing Problems composite (B = 2.29; 95% CI, 0.47-4.11; P = .01) and a 2.14-point increase in T score for the Total Problems composite (B = 2.14; 95% CI, 0.29-3.98; P = .02).Conclusions and RelevanceIn this prospective cohort study of mother-child pairs in Los Angeles, California, prenatal fluoride exposure was associated with increased neurobehavioral problems. These findings suggest that there may be a need to establish recommendations for limiting fluoride exposure during the prenatal period.

show abstract