The hand is a versatile structure that performs numerous tasks, ranging from exertion of great force such as grip, pinch and torque to execution of precise fine motor skills. The aim of current study was to undertake a preliminary study on hand dimensions as potential predictors of female populations native to the forest and savanna zones of Ghana. A total of one hundred (100) female students aged between 17 and 24 years were recruited into this study, comprising of 53 native to the forest zone and 47 native to savanna zone of Ghana between 12th June to 27th July, 2023 at the Department of Anatomy, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology. Statistically significant positive correlation was observed between left hand length and right hand length (R = 0.923, p = 0.000). From the binary regression model, it could be speculated that left-hand breadth could predict female populations native to the savanna zone (LHB: β = − 2.37, Expβ = 0.09, p = 0.014). However, right-hand breadth and length and left hand length did not show any potential of prediction (RHB: β = 0.900, Expβ = 2.460, p = 0.410; RHL: β = 0.168, Expβ = 1.683, p = 0.803; LHL: β = − 0.300, Expβ = 0.741, p = 0.656). The study therefore may speculate that left handbreadth could have the potential to differentiate female populations native to savanna zone from females native to forest zone in Ghana.