Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis

Abstract

Abstract:Objective: Many investigations have studied the associations between matrix metalloproteinase-9 (MMP-9) C1562T polymorphisms and coronary artery disease (CAD). However, the conclusions of these studies were inconsistent. Therefore, this study was aimed at clarifying the association between MMP-9 C1562T polymorphisms and CAD in a large-scale meta-analysis. Methods: The PubMed and Embase databases were retrieved to collect all publications on the association between MMP-9 C1562T polymorphisms and CAD. Then the odd ratios (ORs) and 95% confidence intervals (95% CIs) for C1562T TT+TC versus CC genotype between CAD and the control groups were evaluated. Subgroup analysis was also performed according to different races. The meta-analysis was performed by Stata 10.0. Results: Sixteen case-control studies were included in our meta-analysis, involving 11 032 CAD patients and 4628 non-CAD controls. Compared with C allele carriers, East Asian T allele carriers TT+TC had a significantly higher risk of CAD (OR=1.43; 95% CI: 1.03-1.99; P=0.031); however, there were no significant associations in Western populations (OR=1.06; 95% CI: 0.96-1.18; P=0.240) or West Asians (OR=1.13; 95% CI: 0.75-1.70; P=0.565). When further analyzing the association between C1562T polymorphisms and myocardial infarction (MI, the most serious type of CAD), the risk of TT+TC genotype versus CC genotype for MI was significantly higher for the overall (OR=1.21; 95% CI: 1.04-1.40; P=0.012) and for East Asians (OR=1.58; 95% CI: 1.26-1.97; P=0.000) but not in Western populations (OR=1.12; 95% CI: 0.99-1.26; P=0.078). Conclusions: Our meta-analysis suggested an obvious ethnic difference in the association between MMP-9 C1562T polymorphisms and CAD. MMP-9 C1562T polymorphism was significantly related to CAD in East Asians. However, no significant associations were observed in either West Asians or Western populations.

Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population

“…Alp et al (2009) and Ghaderian et al (2010) did not find a significant association between MMP-9 rs3918242 genetic variation and development of coronary artery disease and myocardial infarction in Turkish and Chinese population. Two recent meta-analysis studies reported that the MMP-9 rs3918242 genetic factors may have association with the risk of coronary artery disease in Asian populations (Wang and Shi, 2014;Zhang et al, 2014). In our study, we found that the TT and CT genotypes and T allele of MMP-9 rs3918242 could influence the development of coronary artery disease in a Chinese population.…”

“…Three main polymorphisms were observed in the promoter, coding and untranslated region of MMP-9 (Zhang et al, 1999). The MMP-9 rs3918242 polymorphism (C ® T) is located at the promoter region, and previous studies have reported that the MMP-9 rs3918242 gene polymorphism plays an important role in the development of coronary artery diseases, but the results are inconclusive (Mishra et al, 2012;Opstad et al, 2013;Xu et al, 2013;Opstad et al, 2014;Wang and Shi, 2014;Zhang et al, 2014). Therefore, we carried out a case-control study to assess the role of one single nucleotide polymorphism (SNP) of MMP-9 rs3918242 in the development of coronary artery disease.…”

Matrix metalloproteinase 9 gene polymorphism 1562C>T is significantly associated with acute coronary syndrome susceptibility in the Vietnamese population

“…In another study on Iranian population, Ghaderian et al also failed to indicate that MMP-9 T allele had www.scienceasia.org an association with increasing risk of developing AMI 15 . Although these studies showed inconsistent results, a plausible explanation may be drawn from the study of Wang and Shi 21 . Using meta-analysis of 16 case-control studies, the authors suggested that MMP-9 1562C>T polymorphism was an occurrence of coronary artery diseases in the East Asian but not in the West Asian 21 .…”

“…Using meta-analysis of 16 case-control studies, the authors suggested that MMP-9 1562C>T polymorphism was an occurrence of coronary artery diseases in the East Asian but not in the West Asian 21 . This difference could be explained by the genetic specificity of population ethnicity 18,21 .…”

Concomitant coronary and renal revascularization improves left ventricular hypertrophy more than coronary stenting alone in patients with ischemic heart and renal disease

“…Mechanisms by which coexistence of CAD and ARAS is associated with HFpEF are under investigation (Groban and Kitzman, 2010;Wang and Shi, 2014). The progressive increase in cardiac diastolic dysfunction leading to a worsening of CAD and ARAS is partly explained by factors such as increased afterload, renal hypertension resulting from ARAS, myocardial ischemia, overactivation of RAAS, and inflammation (Ding et al, 2014).…”