Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women

Sull, Jae Woong; Kim, Gitae; Jee, Sun Ha

doi:10.1186/s12881-020-01100-3

Cited by 15 publications

(7 citation statements)

References 24 publications

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“…Moreover, a number of studies have shown the association of polymorphisms within MC4R and the development of T2D [32]. Particularly, it was reported, that the MC4R rs17782313 C allele is most often associated with an increased T2D risk [33].…”

Section: Discussionmentioning

confidence: 99%

Association of gene polymorphisms with body weight changes in prediabetic patients

et al. 2022

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Background Recent research has demonstrated that Type 2 Diabetes (T2D) risk is influenced by a number of common polymorphisms, including MC4R rs17782313, PPARG rs1801282, and TCF7L2 rs7903146. Knowledge of the association between these single nucleotide polymorphisms (SNPs) and body weight changes in different forms of prediabetes treatment is still limited. The aim of this study was to investigate the association of polymorphisms within the MC4R, PPARG, and TCF7L2 genes on the risk of carbohydrate metabolism disorders and body composition changes in overweight or obese patients with early carbohydrate metabolism disorders. Methods and results From 327 patients, a subgroup of 81 prediabetic female patients (48.7 ± 14.8 years) of Eastern European descent participated in a 3-month study comprised of diet therapy or diet therapy accompanied with metformin treatment. Bioelectrical impedance analysis and genotyping of MC4R rs17782313, PPARG rs1801282, and TCF7L2 rs7903146 polymorphisms were performed. The MC4R CC and TCF7L2 TT genotypes were associated with increased risk of T2D (OR = 1.46, p = 0.05 and OR = 2.47, p = 0.006, respectively). PPARG CC homozygotes experienced increased weight loss; however, no additional improvements were experienced with the addition of metformin. MC4R TT homozygotes who took metformin alongside dietary intervention experienced increased weight loss and reductions in fat mass (p < 0.05). Conclusions We have shown that the obesity-protective alleles (MC4R T and PPARG C) were positively associated with weight loss efficiency. Furthermore, we confirmed the previous association of the MC4R C and TCF7L2 T alleles with T2D risk.

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Section: Discussionmentioning

confidence: 99%

Association of gene polymorphisms with body weight changes in prediabetic patients

et al. 2022

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“…Moreover, a number of studies have shown the association of polymorphisms within MC4R and the development of T2D [30]. Particularly, it was reported, that the C allele of rs17782313 MC4R is most often associated with an increased T2D risk [31].…”

Section: Discussionmentioning

confidence: 99%

Association of gene polymorphisms with body weight changes in prediabetic patients

Валеева

Medvedeva

Khasanova

et al. 2021

Preprint

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Background: Recent research has demonstrated that Type 2 Diabetes (T2D) risk is influenced by a number of common polymorphisms, including rs17782313 MC4R, rs1801282 PPARG, and rs7903146 TCF7L2. Knowledge of the association between these SNPs (single nucleotide polymorphism) and body weight changes in different forms of prediabetes treatment is still limited. The aim of this study was to investigate the association of polymorphisms within the MC4R, PPARG, TCF7L2 genes on the risk of carbohydrate metabolism disorders and body composition changes in overweight or obese patients with early carbohydrate metabolism disorders. Methods and Results: From 327 patients, a subgroup of 81 prediabetic female patients (48.7±14.8 years) of Eastern European descent participated in a 3-month study comprised of diet therapy or diet therapy accompanied with metformin treatment. Bioelectrical impedance analysis and genotyping of rs17782313 MC4R, rs7903146 TCF7L2, rs1801282 PPARG were performed. The MC4R CC and TCF7L2 TT genotypes were associated with increased risk of T2D (OR=1.46, p=0.05 and OR=2.47, p=0.006, respectively). PPARG СС homozygotes experienced increased weight loss; however, no additional improvements were experienced with the addition of metformin. MC4R ТТ homozygotes who took metformin alongside dietary intervention experienced increased weight loss and reductions in fat mass (p<0.05).Conclusions: We confirmed the previous association of the MC4R C and TCF7L2 T alleles with T2D risk. The obesity-protective alleles (MC4R T and PPARG C) were positively associated with weight loss efficiency.

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“…Поскольку ожирение связано с повышенным риском СД2, во многих исследованиях изучалась связь между полиморфизмом в районе гена MC4R и риском СД2 в различных этнических группах с противоречивыми результатами [43][44][45]. Так, rs17782313 показал связь с диабетом в нескольких исследованиях «случай-контроль» [46][47][48]. Обширный метаанализ, включающий 123 373 человека, подтвердил независимую от ИМТ значимую связь полиморфизма rs17782313 вблизи гена MC4R с риском СД2 в исследуемой популяции, состоящей из европейцев и азиатов [46].…”

Section: результатыunclassified

Association of polymorphisms of genes SLC30A8 and MC4R with the prognosis of the development of type 2 diabetes mellitus

et al. 2022

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BACKGROUND: The prevalence of Type 2 diabetes mellitus (T2DM) has reached epidemic proportions and it is estimated to affect over 400 million people worldwide. Moreover, the incidence of diabetes is expected to continue to rise and it is projected to affect nearly one of the three individuals by the year 2050. These alarming projections suggest that there is an urgent need for the development and implementation of novel prevention and treatment strategies to combat the rise in T2DM.AIM: To study the possibility of using polymorphisms of genes SLC30A8 and MC4R as markers for predicting the development of T2D in the population of Novosibirsk.MATERIALS AND METHODS: On the basis of prospective follow-up of a representative population sample of residents of Novosibirsk (The HAPIEE Project), 2 groups were formed according to the “case-control” principle (case — people who had diabetes mellitus 2 over 10 years of follow-up, and control — people who did not developed disorders of carbohydrate metabolism). T2D group (n = 443, mean age 56.2 ± 6.7 years, men — 29.6%, women — 70.4%), control group (n = 532, mean age 56.1 ± 7.1 years, men — 32.7%, women — 67.3%). DNA was isolated by phenol-chloroform extraction. Genotyping was performed by the method of polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism, polymerase chain reaction in real time. Statistical processing was carried out using the SPSS 16.0 software package.RESULTS: Genotype TT rs13266634 of the SLC30A8 gene was associated with the risk of developing T2D (relative risk — RR 1.51, 95% confidence interval — CI 1.11–2.05, p =0.008). The CC genotype rs13266634 of the SLC30A8 gene was associated with a protective effect against T2D (RR 0.57, 95% CI 0.35–0.92, p=0.026). No significant effect of rs17782313 of the MC4R gene on the risk of developing T2D was found.CONCLUSION: The rs13266634 polymorphism of the SLC30A8 gene confirmed its association with the prognosis of the development of T2D, which indicates the possibility of considering it as a candidate for inclusion in a diabetes risk score. The association between polymorphisms rs17782313 of the MC4R gene and the prognosis of the development of T2D was not found.

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Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women

Cited by 15 publications

References 24 publications

Association of gene polymorphisms with body weight changes in prediabetic patients

Association of gene polymorphisms with body weight changes in prediabetic patients

Association of gene polymorphisms with body weight changes in prediabetic patients

Association of polymorphisms of genes SLC30A8 and MC4R with the prognosis of the development of type 2 diabetes mellitus

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