Association of mean platelet volume with angiographic thrombus burden and short‐term mortality in patients with ST‐segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Lai, Hong-Mei; Xu, Rui; Yang, Yining; Ma, Yun; Li, Xiaomei; Chen, Qingjie; Zhai, Hua‐Jin; Liu, Fen; Chen, Bang‐Dang

doi:10.1002/ccd.25860

Cited by 26 publications

(22 citation statements)

References 37 publications

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“…30) Although the pooled analysis of four ISAR trials 19) and a subgroup analysis of the CADILLAC trial 18) confirmed that a higher baseline PC was a predictor of adverse prognosis in patients undergoing PCI, other studies found no significant association between baseline PC and adverse prognosis in patients with STEMI undergoing PCI. [11][12][13][14]22) Our study confirmed again that high MPV was an independent predictor of adverse prognosis for patients with STEMI undergoing P-PCI, but high PC was not.…”

Section: Mpv/pc Ratio Predicate Prognosis In Stemisupporting

confidence: 65%

“…15) They noted that MPV was a strong, independent predictor of impaired angiographic reperfusion and 6-month mortality in patients with STEMI undergoing PCI. 15) This observation has since been confirmed by several other studies [10][11][12][13][14]16,17) and has been extended by the observation that elevated MPV at admission was an independent predictor of large intracoronary thrombus burden.…”

Section: Mpv/pc Ratio Predicate Prognosis In Stemimentioning

confidence: 56%

“…6,8) Increased MPV was confirmed to be related with coronary artery disease (CAD). 9) Further, recent researches have shown that increased MPV was associated with a worse short-term [10][11][12][13][14] and long-term 11,[15][16][17] prognosis, as well as angiographic thrombus burden 13) and impaired myocardial reperfusion 12,14,15) in patients with STEMI undergoing P-PCI. And platelet count (PC) has been determined as an important predictor of adverse events in patients with CAD undergoing PCI.…”

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confidence: 99%

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Predictive Value of Mean Platelet Volume/Platelet Count for Prognosis in Acute Myocardial Infarction

Tian

Song

et al. 2018

Int. Heart J.

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SummaryIncreased mean platelet volume (MPV) has been associated with adverse clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). We aim to assess whether MPV/platelet count (MPV/PC) ratio is a useful marker to predict long-term prognosis in patients with STEMI undergoing PCI. Moreover, the prognostic accuracy of MPV/PC ratio is compared with MPV. 962 consecutive patients with STEMI treated with P-PCI were considered. According to the admission MPV/PC values, the population was divided into two groups: high MPV/PC group (n = 320, MPV/PC !0.055) and low MPV/PC group (n = 642, MPV/PC < 0.055). Multivariate analysis showed that high MPV/PC was an independent predictor of major adverse cardiovascular event (MACE; hazard ratio [HR]: 1.121, 95% confidence interval [CI]: 1.056-1.190, P < 0.01), all-cause mortality (HR: 1.109, 95% CI: 1.016-1.209, P = 0.020), cardiac mortality (HR: 1.141, 95% CI: 1.038-1.253, P = 0.006), nonfatal myocardial reinfarction (HR: 1.148, 95% CI: 1.044-1.262, P = 0.004), and unplanned repeat revascularization (HR: 1.073, 95% CI: 1.007-1.144, P = 0.030), respectively. MPV/PC ratio has good accuracy for predicting MACE (the area under the receiver-operating characteristic curve: 0.764), and the cut-off value was 0.054 with a sensitivity of 0.813 and a specificity of 0.662. The discriminatory performance of MPV/PC ratio was better than MPV for predicting MACE (MPV/PC ratio versus MPV: z = 2.285, P = 0.022), in patients with STEMI undergoing P-PCI. MPV/PC ratio is able to but better than MPV to predict long-term adverse outcomes in patients with STEMI undergoing P-PCI.(Int Heart J Advance Publication)

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Section: Mpv/pc Ratio Predicate Prognosis In Stemisupporting

confidence: 65%

Section: Mpv/pc Ratio Predicate Prognosis In Stemimentioning

confidence: 56%

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confidence: 99%

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Predictive Value of Mean Platelet Volume/Platelet Count for Prognosis in Acute Myocardial Infarction

Tian

Song

et al. 2018

Int. Heart J.

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“…There has been rapidly growing interest in the association between MPV and the risk of cardiovascular events following STEMI. High MPV is an independent predictor of large intracoronary thrombus burden and short-term mortality in STEMI patients (Lai et al, 2015). Also, it is associated with lower ST-segment resolution and higher prevalence of major adverse cardiac events in patients receiving thrombolytic therapy for first time STEMI (Ghaffari et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction

Hudzik

Szkodziński

Lekston

et al. 2016

Journal of Diabetes and its Complications

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“…[29,31]. После публикации последне-го метаанализа в 2015 г. появилось еще не-сколько работ, подтверждающих прогностичес-кую значимость СОТ у больных с ОКС [32,41,42]. По крайней мере, в одном исследовании была выявлена корреляция СОТ с риском тромбо-зов после ЧКВ у больных со стабильной ИБС [43].…”

Section: средний объем тромбоцитов у больных с сердечно-сосудистыми пunclassified

Platelet Turnover and Atherothrombosis

Мазуров¹

2017

Aterotromboz

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ОБОРОТ ТРОМБОЦИТОВ И АТЕРОТРОМБОЗА.В. МАЗУРОВ, д.м.н., профессор, Научный медицинский исследовательский центр кардиологии Минздрава России, Москва КЛЮЧЕВЫЕ СЛОВА: тромбоциты, атеротромбоз, ретикулярные тромбоциты, средний объем тромбоцитов, агрегация тромбоцитов, мегакариоциты, тромбоцитопоэз Тромбоциты играют ведущую роль в инициации атеротромбоза -образования внутрисо-судистых тромбов в участках атеросклеротическом повреждении сосудов. Функциональ-ная (протромботическая) активность тромбоцитов существенным образом варьирует как у здоровых лиц, так и у пациентов с сердечно-сосудистыми заболеваниями. Одной из причин повышения активности тромбоцитов может быть ускорение их продукции и оборота. При стимуляции тромбоцитопоэза в кровотоке появляются крупные и ретику-лярные (с повышенным количеством РНК) «молодые» тромбоциты. Эти тромбоциты со-держат больше адгезивных рецепторов, больше секреторных гранул и обладают повы-шенной способностью к агрегации. В обзоре приводятся данные, указывающие на то, что крупные и ретикулярные тромбоциты являются не только маркерами, но и предик-торами атеротромботических событий, и в первую очередь острого коронарного синдро-ма. Увеличение количества таких тромбоцитов у больных, получающих антитромбоци-тарные препараты, ассоциировано со снижением эффективности их антиагрегантного действия. Предполагается, что появление крупных и ретикулярных тромбоцитов в кро-ви больных с атеросклерозом и атеротромбозом может быть следствием повышения тромбопоэтической активности мегакариоцитов при этих патологических состояниях.KEYWORDS: thrombocytes, atherothrombosis, reticular platelets, average platelet count, platelet aggregation, megakaryocytes, thrombocytopoiesis PLATELET TURNOVER AND ATHEROTHROMBOSIS A.V. MAZUROV, MD, Prof. National Medical Research Cardiology Center, Russian Ministry of Health, MoscowPlatelets play an important role in initiating atherothrombosis, i.e. the formation of blood clots inside a blood vessel at areas of atherosclerotic vascular injury. The functional (prothrombotic) activity of platelets significantly varies both in healthy individuals and in patients with cardiovascular diseases. The increased platelet production and turnover may be one of the reasons for promoting platelet activity. Stimulating thrombocytopoiesis results in large and reticular (with an increased amount of RNA) "young" platelets in the bloodstream. These platelets contain more adhesive receptors, more secretory granules and have an increased aggregation capacity. The review provides data indicating that large and reticular platelets are not only markers, but also predictors of atherothrombotic events, and primarily of acute coronary syndrome. An increase in such platelet count in patients receiving antiplatelet drugs is associated with a decrease in effectiveness of their antiplatelet action. It is assumed that the appearance of large and reticular platelets in the blood of patients with atherosclerosis and atherothrombosis may be a consequence of an increase in the thrombopoietic activity of meg...

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Association of mean platelet volume with angiographic thrombus burden and short‐term mortality in patients with ST‐segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Abstract: Increased MPV at admission is an independent predictor of large intracoronary thrombus burden and short-term mortality. It may be a useful biomarker for risk stratification in patients with STEMI undergoing primary PCI. © 2015 Wiley Periodicals, Inc.

Cited by 26 publications

References 37 publications

Predictive Value of Mean Platelet Volume/Platelet Count for Prognosis in Acute Myocardial Infarction

Predictive Value of Mean Platelet Volume/Platelet Count for Prognosis in Acute Myocardial Infarction

Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction

Platelet Turnover and Atherothrombosis

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