Association of mean Platelet volume with DSM-IV major depression in a large community-based population: The MELEN study

Canan, Fatih; Dikici, Süber; Kutlucan, Ali; Celbek, Gökhan; Coskun, Hulya; Güngör, Âdem; Aydın, Yusuf; Kocaman, Gulsen

doi:10.1016/j.jpsychires.2011.11.016

Cited by 76 publications

(51 citation statements)

References 43 publications

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“…Our results are in line with another study that demonstrated increased MPV levels were associated with depression in a large population (Canan et al, 2012). Likewise, elevated MPV levels were also found in patients with fibromyalgia syndrome as well as bipolar disorder (Vural et al, 2015; Yildirim, Solmaz, Akgol, & Ersoy, 2016).…”

Section: Discussionsupporting

confidence: 93%

“…As a routinely available measure of platelet size at admission, MPV can be considered as a biological indicator of platelet activity (Chu, et al, 2010), which was correlated with depression (Musselman, et al, 1996; Shimbo et al, 2002). This accorded well with one study based on a large population, which reported that elevated MPV levels were associated with major depression (Canan, et al, 2012). Meanwhile, it has been shown that escitalopram effect of inhibiting reuptake of serotonin occurs in neurons as well as platelets, reducing platelet reactivity (Atar et al, 2006).…”

Section: Discussionsupporting

confidence: 90%

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The association between mean platelet volume levels and poststroke depression

Qiu

Liu

et al. 2018

Brain and Behavior

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ObjectiveHigh levels of mean platelet volume (MPV) had been found in depression subjects. We sought to examine the relationship between MPV and poststroke depression (PSD).MethodsOne hundred and eighty‐five patients with acute ischemic stroke were enrolled in our study. Peripheral venous blood samples were drawn at admission and MPV levels were measured by the automated hematology analyzer. Patients with a HAMD‐17 score >7 were diagnosed as having PSD.ResultsWe found that 60 patients (32.4%) developed PSD, the MPV levels in PSD patients were significantly higher (9.3 ± 1.8 fl) compared to non‐PSD patients (8.5 ± 1.6 fl). High MPV levels (≥9.1 fl) were independently correlated with PSD (OR 2.762, 95% CI 1.138–6.702, p = 0.025).ConclusionsPatients with higher levels of MPV at admission were correlated with the development of PSD at 1 month after stroke and might be a predictor of its presence.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

The association between mean platelet volume levels and poststroke depression

Qiu

Liu

et al. 2018

Brain and Behavior

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“…The number of studies about MPV values in the field of psychiatry is scarce. In their large scale study, Canan et al [26] showed that MPV values were increased in major depression patients, and these values were decreased after 8 weeks of escitalopram treatment. Results of the studies about MPV values in panic disorder patients were contradictory.…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume level in patients with generalized anxiety disorder

Almış

Aksoy

2017

Psychiatry and Clinical Psychopharmacology

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OBJECTIVE: Generalized anxiety disorder (GAD) is characterized by persistent and chronic anxiety state. Stressful life events and anxiety usually cause an increase in platelet volume and activity through various mechanisms. Mean platelet volume (MPV), which is indicative of platelet size, is accepted as an indication of platelet activity. METHOD: In this first retrospective cohort study about MPV among GAD patients, we compared complete blood count especially in terms of platelet count (PLT), platelet distribution width (PDW), plateletcrit (PCT) and MPV values of 60 GAD patients with 60 healthy controls. RESULTS: MPV was found to be significantly higher (p = .008) and platelet count was found to be significantly lower in the GAD group (p = .001). The area under the ROC curve (AUC) of MPV levels for GAD was 0.655 (95% CI: 0.557-0.754, p < .001). DISCUSSION: Increased MPV levels in GAD patients in our study supports the hypothesis of increased platelet activation due to sympathetic system activation. Also platelet levels were found to be significantly lower in GAD patients in our study. This finding is consistent with the non-linear inverse relation between platelet volume and platelet count. According to ROC curve analysis for differentiation of GAD from those in the control group, MPV would be considered to be a "poor" biochemical marker. We believe that further controlled prospective studies about this issue will be valuable. ARTICLE HISTORY

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“…Patients who had suffered a myocardial infarction and those with the unstable angina pectoris display increased values of MPV compared to the patients suffering from the stable angina pectoris and compared to the patients with chest pain of non-cardiac origin. An increase of MPV has been even recognized as an independent risk factor for the development of myocardial infarction or stroke [36]. In the study of Canan et al from 2011, the authors investigated the relation between MPV, as an index of the activity of thrombocytes and depression in the adult population of Turkey [37].…”

Section: Development Of Thrombocytes and Thrombocyte Indicesmentioning

confidence: 99%

The role of thrombocyte serotonin system and some thrombocyte characteristics in treatment of depressive patients with cardiovascular diseases

Kostanjšak¹,

Zdunić

2017

Alcoholism and Psychiatry Research

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-Serotonin has an important role in the development of depressive disorders. Bearing in mind that direct testing of central nervous system is unavailable to researchers due to the inability to reach the samples, ever greater attention is given to the peripheral systems that can help us diagnose and detect changes of the disease, but also follow the course of its treatment and recovery. Thrombocyte is a blood cell that contains serotonin lodged in its delta granules. Thrombocyte serotonin system is similar, although not the same as the serotonin system in central nervous system. The most important differences are that in thrombocytes, serotonin is broken down by the enzyme monoaminooxidase B (MAO-B), while that function in neuron is carried out by monoaminooxidase A (MAO-A) and that a thrombocyte cannot synthetize serotonin itself, because it lacks tryptophan hydroxylase. Nowadays, in the treatment of depressive disorders, mostly the selective inhibitors of serotonin uptake (SIPPS) are being used. The research has proved that therapy with those medications changes the concentration of serotonin in thrombocytes and changes the values of some thrombocyte indices. The thrombocyte serotonin is a powerful vasoconstrictor, which increases the cardiovascular risk and the probability of thrombogenesis. The mean volume of thrombocytes (MPV) is a positive index of thrombocyte activity and the increase of MPV represents an independent risk factor for the development of cardiovascular diseases. It is of enormous significance to recognize the depression in patients who suffer from cardiovascular diseases. Depression interferes with the recovery of those patients, because it reduces the personal engagement in it and disturbs patients' compliance and the motivation for treatment. Besides the fact that the treatment with SIPPS leads to the regression of symptoms of depression, it also changes the concentration of thrombocyte serotonin and the mean volume of thrombocytes towards the values that reduce their role in pathogenesis of cardiovascular diseases, thus reducing the risk of re-occurrence of cardiovascular incidents and improving the patients' recovery.

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Association of mean Platelet volume with DSM-IV major depression in a large community-based population: The MELEN study

Cited by 76 publications

References 43 publications

The association between mean platelet volume levels and poststroke depression

The association between mean platelet volume levels and poststroke depression

Mean platelet volume level in patients with generalized anxiety disorder

The role of thrombocyte serotonin system and some thrombocyte characteristics in treatment of depressive patients with cardiovascular diseases

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