Association of Medical Male Circumcision and Sexually Transmitted Infections in a Population-Based Study: A Targeted Maximum Likelihood Estimation Approach
Abstract:Background: Epidemiological theory and many empirical studies support the hypothesis that there is a protective effect of male circumcision against some sexually transmitted infections (STIs). However, there is a paucity of randomized control trials (RCTs) to test this hypothesis in the South African population. Due to the infeasibility of conducting RCTs, estimating marginal or average treatment effects with observational data, are of increasing interest. Using targeted maximum likelihood estimation (TMLE), a… Show more
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