Association of menopausal symptom severity and osteoporotic fractures: a case-control study

Jaber, Ruba M.; Khalil, Ibrahim A.; Almohtasib, Yazan Salah; Hamdan, Mohammad; AlRyalat, Saif Aldeen

doi:10.1080/08952841.2020.1803183

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…There was evidence for 33 and against parity 34 and some evidence of association for hyperthyroidism, 86 , 99 lumbar 1–2 bone density or fracture, 37 , 69 use of estrogen or hormone therapy, 50 , 76 higher gravidity, 68 older age at second abortion, 71 diet (e.g. high animal fat, 67 low soy 100 ), use of Chinese herbal medicine, 89 and having a Chinese medical diagnosis of Yang-xu.…”

Section: Resultsmentioning

confidence: 99%

Correlates of palpitations during menopause: A scoping review

Carpenter

Sheng

Pike

et al. 2022

Womens Health (Lond Engl)

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Objective: Palpitations during peri- and post-menopause are common. It is unclear what variables are related to palpitations in peri- and post-menopausal women. The purpose of this scoping review was to summarize potential correlates of palpitations in women transitioning through menopause. Methods: The review followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Authors included English-language, full-length, peer-reviewed, cross-sectional research articles on palpitations in menopausal women published through December 18, 2021, from PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PsycINFO searches. Following de-duplication, screening of titles and abstracts, and review of full-texts, independent reviewers extracted data on variables studied in relationship to palpitations from 84 articles and resolved discrepancies. Authors extracted data on (1) demographic, clinical, biomarker, and symptom/quality of life variables and (2) data analysis method (bivariate, multivariate). Authors classified each variable as a likely, unlikely, or unclear correlate of palpitations. Results: Articles were diverse in region of origin, sample sizes, and variables assessed in relationship to palpitations. Evidence for any one variable was sparse. Likely correlates of palpitations included race/ethnicity, lower physical activity, worse vasomotor symptoms (VMSs), worse sleep, and worse quality of life. Unlikely correlates included age, employment, education, marital status, socioeconomic status, comorbidities, body mass index, and sexual difficulties. Unclear correlates due to equivocal evidence were menopausal status, smoking, and depression. Unclear correlates due to insufficient evidence (less than three articles) included all of the assessed biomarkers, anxiety, and stress. Conclusion: Likely correlates were identified including race/ethnicity, physical activity, VMS, sleep, and quality of life. However, additional research is needed to better understand potential correlates of palpitations.

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Section: Resultsmentioning

confidence: 99%

Correlates of palpitations during menopause: A scoping review

Carpenter

Sheng

Pike

et al. 2022

Womens Health (Lond Engl)

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The association of vasomotor symptoms with fracture risk and bone mineral density in postmenopausal women: a systematic review and meta-analysis of observational studies

Anagnostis,

Lallas,

Pappa

et al. 2024

Osteoporos Int

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Background/Aims Vasomotor symptoms (VMS) adversely affect postmenopausal quality of life. However, their association with bone health has not been elucidated. This study aimed to systematically review and meta-analyze the evidence regarding the association of VMS with fracture risk and bone mineral density (BMD) in peri- and postmenopausal women. Methods A literature search was conducted in PubMed, Scopus and Cochrane databases until 31 August 2023. Fracture, low BMD (osteoporosis/osteopenia) and mean change in lumbar spine (LS) and femoral neck (FN) BMD were assessed. The results are presented as odds ratio (OR) and mean difference (MD), respectively, with a 95% confidence interval (95% CI). The I 2 index quantified heterogeneity. Results Twenty studies were included in the qualitative and 12 in the quantitative analysis ( n =49,659). No difference in fractures between women with and without VMS was found ( n =5, OR 1.04, 95% CI 0.93–1.16, I 2 16%). However, VMS were associated with low BMD ( n =5, OR 1.54, 95% CI 1.42–1.67, I 2 0%). This difference was evident for LS (MD -0.019 g/cm 2 , 95% CI -0.03 to -0.008, I 2 85.2%), but not for FN BMD (MD -0.010 g/cm 2 , 95% CI -0.021 to 0.001, I 2 78.2%). These results were independent of VMS severity, age and study design. When the analysis was confined to studies that excluded menopausal hormone therapy use, the association with BMD remained significant. Conclusions The presence of VMS is associated with low BMD in postmenopausal women, although it does not seem to increase fracture risk. Supplementary Information The online version contains supplementary material available at 10.1007/s00198-024-07075-8.

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Association of menopausal symptom severity and osteoporotic fractures: a case-control study

Cited by 2 publications

References 16 publications

Correlates of palpitations during menopause: A scoping review

Correlates of palpitations during menopause: A scoping review

The association of vasomotor symptoms with fracture risk and bone mineral density in postmenopausal women: a systematic review and meta-analysis of observational studies

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