Association of menstrual and reproductive factors with breast cancer risk: Results from the Shanghai breast cancer study

Gao, Yu Tang; Shu, Xiao Ou; Dai, Qi; Potter, John D.; Brinton, Louise A.; Wen, Wanqing; Sellers, Thomas A.; Kushi, Lawrence H.; Ruan, Zhi; Bostick, Roberd M.; Jin, Fan; Wang, Zheng

doi:10.1002/1097-0215(20000715)87:2<295::aid-ijc23>3.0.co;2-7

Cited by 254 publications

(227 citation statements)

References 20 publications

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“…Details of the SBCS have been described previously (3). Briefly, cases were identified through a rapid case-ascertainment system supplemented by the population-based Shanghai Cancer Registry.…”

Section: Methodsmentioning

confidence: 99%

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History of benign breast disease and risk of breast cancer among women in China: a case–control study

Dorjgochoo

Deming

Gao

et al. 2008

Cancer Causes Control

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Section: Methodsmentioning

confidence: 99%

“…30-40% in most countries, including China, where the rate has risen particularly among women aged 50 or older (3).…”

mentioning

confidence: 99%

History of benign breast disease and risk of breast cancer among women in China: a case–control study

Dorjgochoo

Deming

Gao

et al. 2008

Cancer Causes Control

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“…7 Briefly, all women age 25-64 years who were permanent residents of urban Shanghai at the time of diagnosis of first primary invasive breast cancer (August 1996 through March 1998) were eligible for the study. Two senior pathologists histologically confirmed all diagnoses.…”

Section: Methodsmentioning

confidence: 99%

Abortion history and breast cancer risk: Results from the Shanghai breast cancer study

et al. 2001

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Studies of the association between induced abortion and breast cancer risk have been inconsistent, perhaps due to underreporting of abortions. Induced abortion is a well-accepted family planning procedure in China, and women who have several induced abortions do not feel stigmatized. The authors used data from a population-based case-control study of breast cancer among women age 25-64 conducted between 1996 and 1998 in urban Shanghai to assess whether a history of and the number of induced abortions were related to breast cancer risk. In-person interviews were completed with 1,459 incident breast cancer cases ascertained through a population-based cancer registry, and 1,556 controls randomly selected from the general population in Shanghai (with respective response rates of 91% and 90% Studies of induced abortion and breast cancer risk have been inconsistent. Underreporting of induced abortion is suspected, 1 which may be reflected in the low reported percentages of women who had undergone the procedure in these studies. In the majority of previous studies of this association fewer than 20% of women have reported induced abortions. The Iowa Women's Health Study, a cohort study, had the lowest percentage of reported induced abortions (2%), and found no association between induced abortion and breast cancer risk (OR ϭ 1.1, 95% CI 0.8 -1.6). 2 An intermediate percentage of reported induced abortions (39%) was found in a Greek case-control study that reported an elevated risk of breast cancer associated with induced abortion (OR ϭ 1.51, 95% CI 1.28 -1.84). 3 The highest percentage of reported induced abortions (76%) was seen in a Russian case-control study that reported no association for 1 abortion (OR ϭ 1.0, 95% CI 0.7-1.4) and a borderline reduced risk for 2 or more abortions (OR ϭ 0.7, 95% CI 0.6 -1.0). 4 Remennick 5 postulated that should induced abortion be related to breast cancer Russian women may be at a greater risk given the extremely frequent use of the procedure. The same may be true of women in China that had 1 of the highest induced abortion rates in the world during the childbearing years for the majority of women in this study. 6 This study was conducted to assess whether a history of and the number of induced abortions were related to breast cancer risk. The lack of social stigma associated with induced abortion in China may limit the amount of underreporting of the procedure and present a clearer picture of this association. MATERIAL AND METHODSDetailed methods of this population-based case-control study appear elsewhere. 7 Briefly, all women age 25-64 years who were permanent residents of urban Shanghai at the time of diagnosis of first primary invasive breast cancer (August 1996 through March 1998) were eligible for the study. Two senior pathologists histologically confirmed all diagnoses. We used rapid case ascertainment supplemented by the Shanghai Cancer Registry to identify breast cancer cases who had no prior history of cancer and were alive at the time of interview. A total of 1,459 breas...

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“…This study examined surgically-resected tumor tissues and adjacent normal tissues of 55 patients with primary breast cancer and 21 patients with BBD, who are a subset of patients recruited as part of the Shanghai Breast Cancer Study (10). These patients were diagnosed with breast cancer or BBD between 1996 and 1998 and were identified through a network of major hospitals that treat over 80% of breast cancer patients in urban Shanghai.…”

Section: Study Subjects and Control Samplesmentioning

confidence: 99%

Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases

Shu

Wen

et al. 2007

Breast Cancer Res Treat

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The mitochondrial DNA (mtDNA) 4977-bp deletion ( mtDNA 4977 mutation) is one of the most frequently observed mtDNA mutations in human tissues, and may play a role in carcinogenesis. Only a few studies have evaluated mtDNA 4977 mutation in breast cancer tissue, and the findings have been inconsistent, which may be due to methodological differences. In this study, we developed a quantitative real-time PCR assay to assess the level of the mtDNA 4977 mutation in tumor tissue samples from 55 primary breast cancer patients and 21 patients with benign breast disease (BBD). The mtDNA 4977 mutation was detected in all of the samples with levels varying from 0.000149% to 7.0%. The mtDNA 4977 mutation levels were lower in tumor tissues than in adjacent normal tissues in both breast cancer and BBD subjects. The differences, however, were not statistically significant. No significant difference between breast cancer and BBD patients was found in the mtDNA 4977 mutation levels of tumor tissues and adjacent normal tissues. The mtDNA 4977 mutation levels were not significantly associated with clinicopathological characteristics (age, histology, tumor stage, and ER/PR status) in breast cancer or BBD patients. These results do not support the notion that the mitochondrial DNA 4977-bp deletion plays a major role in breast carcinogenesis.

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Association of menstrual and reproductive factors with breast cancer risk: Results from the Shanghai breast cancer study

Cited by 254 publications

References 20 publications

History of benign breast disease and risk of breast cancer among women in China: a case–control study

History of benign breast disease and risk of breast cancer among women in China: a case–control study

Abortion history and breast cancer risk: Results from the Shanghai breast cancer study

Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases

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