Association of metabolic biomarkers of cardiovascular disease in overweight and obese children in Emohua Local Government Area of Rivers State, Nigeria

Godwill, Orluwene Chituru; Isaac, Nnatuanya

doi:10.9790/0853-0134046

Cited by 2 publications

(3 citation statements)

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“…This finding suggests that increased ALT levels are not solely a result of the presence of obesity but may suggest an ethnic or genetic predisposition to high ALT levels. In addition, this possible predisposition combined with increased IR could subsequently lead to an increased risk of NAFLD in this young Latinx population 9,40 . van Vliet et al reported a higher incidence of IR in cases with high ALT in multiethnic youth aged 3 to 18 years.…”

Section: Discussionmentioning

confidence: 99%

“…Children with obesity can have altered glycemic markers, including glucose, hemoglobin A1c (HbA1c), insulin, and the homeostasis model assessment (HOMA), which can provide an indirect assessment of IR. In addition, dyslipidemia is commonly associated with obesity, including abnormalities in total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides 9 . Inflammation may be an important mediator for many of the problems associated with obesity.…”

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confidence: 99%

“…Inflammation may be an important mediator for many of the problems associated with obesity. Its primary marker is C-reactive protein (CRP), which is produced in the liver in response to an increased level of cytokines 9,10 . Finally, adults and children with obesity can have elevated liver enzymes aspartate aminotransferase (AST), and alanine aminotransferase (ALT).…”

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confidence: 99%

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Differences in Cardiometabolic Biomarkers between Elementary School–Age Latinx Children with Obesity versus Healthy Weight

McKay

Jones²,

Gallo

2023

Southern Medical Journal

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Objectives: Low-income Latinx youth are disproportionately affected by obesity, which results in an increased risk of cardiometabolic abnormalities. Biomarker tracking may be useful for the early identification of obesity comorbidities in young Latinx children. Hence, we aimed to compare cardiometabolic biomarkers between age-and sex-matched pairs of elementary school-aged Latinx children with obesity versus healthy weight.Methods: This case-control study compared cardiometabolic biomarkers between 13 pairs of age-and sex-matched elementary school-age (median 6.5 years) Latinx children with obesity (body mass index for age ≥ 95th percentile) as compared with their healthy weight (between the 5th and 85th percentiles) counterparts. Anthropometric measures and a fasted venous blood sample were taken for the analysis of lipids, glycemic, inflammatory, endocrine, and hepatic markers. Group differences were tested by the Mann-Whitney U or χ 2 test.Results: Cases had higher insulin (P = 0.003), hemoglobin A1c (P = 0.002), triglycerides (P = 0.023), and C-reactive protein (P < 0.001) and lower high-density lipoprotein (P = 0.002). Hepatic markers were similar, with alanine aminotransferase elevated among both groups. Conclusions:The aforementioned biomarkers may be more sensitive to higher adiposity risk in this young Latinx population; however, elevated hepatic markers may indicate an ethnic/genetic predisposition to abnormal liver function. Research should be replicated in a larger group to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

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