Association of Metabolic Syndrome and Asthma Status: A Prospective
Study from Guilan Province, Iran

Nejatifar, Fatemeh; Foumani, Ali Alavi; Poor, Ahmad Reza Ghorban; Nejad, Azita Tangestani

doi:10.2174/1871530321666210305125059

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Ten studies evaluating the association between asthma and MetS were included in our review, and their overall results were similar. In the prospective cohort study by Nejatifar et al 39 , the correlations of WC with asthmatic spirometry indices, DM, hypertriglyceridemia, and hypertension were signi cantly negative (P < 0.05). Brumpton et al 40 also conducted a prospective cohort study, which showed that MetS is a risk factor for incident asthma (adjusted OR 1.57, 95% CI 1.31-1.87).…”

Section: Asthma and Metsmentioning

confidence: 89%

“…Similarly, an analysis of the 2007 to 2012 KNHANES data indicated that individuals with MetS had a signi cantly higher prevalence of asthma (adjusted OR 1.34, 95% CI 1.09-1.64) 41 . All seven of the reviewed studies concluded that a high WC is a signi cant risk factor for asthma, evidenced by the adjusted OR [39][40][41][42][43][44][45] .…”

Section: Asthma and Metsmentioning

confidence: 99%

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Associations between metabolic syndrome and allergic diseases: a nationwide study in Korea and literature review

Kwon,

An,

et al. 2024

Preprint

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Atopic dermatitis (AD), allergic rhinitis (AR), and asthma are typical allergic diseases, with a common pathogenesis involving increased type 2 immunity. Despite numerous studies, the association between these diseases and metabolic syndrome (MetS) remains controversial. This study aimed to explore relationships between AD, AR, and asthma both to MetS and to each of its components. Population-based, cross-sectional data were obtained from the Korean National Health and Nutrition Examination Survey from 2019 to 2020. Multiple logistic regression analyses were conducted to evaluate the association between allergic diseases and MetS. The results were compared with those of previous studies of the association between MetS and allergic diseases, identified in a literature review following a search of PubMed and the Cochrane Library. Based on assessments of 1,329, 4,824, and 1,172 patients with AD, AR, and asthma, respectively, negative associations between both AD and AR and MetS were determined, after adjusting for confounding factors. By contrast, asthma was positively associated with MetS (odds ratio [OR] 0.58, 95% confidence interval [CI] 0.50–0.67; OR 0.73, 95% CI 0.67–0.78; OR 1.70, 95% CI 1.51–1.92, respectively). The heterogeneous findings highlight the need for further investigation of associations between the studied allergic diseases and MetS as well as each of its components.

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Section: Asthma and Metsmentioning

confidence: 89%

Section: Asthma and Metsmentioning

confidence: 99%

Associations between metabolic syndrome and allergic diseases: a nationwide study in Korea and literature review

Kwon,

An,

et al. 2024

Preprint

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Predictive value of triglyceride-glucose index for the occurrence of acute respiratory failure in asthmatic patients of MIMIC-IV database

Feng,

Lv,

et al. 2024

Sci Rep

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This study aims to investigate the association between the triglyceride-glucose (TyG) index and the occurrence of acute respiratory failure in asthma patients. This retrospective observational cohort study utilized data from the Medical Information Mart for Intensive Care IV (MIMIC-IV 2.2) database. The primary outcome was the development of acute respiratory failure in asthma patients. Initially, the Boruta algorithm and SHapley Additive exPansions were applied to preliminarily determine the feature importance of the TyG index, and a risk prediction model was constructed to evaluate its predictive ability. Secondly, Logistic regression proportional hazards models were employed to assess the association between the TyG index and acute respiratory failure in asthma patients. Finally, subgroup analyses were conducted for sensitivity analyses to explore the robustness of the results. A total of 751 asthma patients were included in the study. When considering the TyG index as a continuous variable, logistic regression analysis revealed that in the unadjusted Model 1, the odds ratio (OR) was 2.381 (95% CI: 1.857–3.052; P < 0.001), in Model II, the OR was 2.456 (95% CI: 1.809–3.335; P < 0.001), and in the multivariable-adjusted model, the OR was 1.444 (95% CI: 1.029–2.028; P = 0.034). A consistent association was observed between the TyG index and the risk of acute respiratory failure in asthma patients. No significant interaction was found between the TyG index and various subgroups ( P > 0.05). Furthermore, machine learning results indicated that an elevated TyG index was a significant feature predictive of respiratory failure in asthma patients. The baseline risk model achieved an AUC of 0.743 (95% CI: 0.679–0.808; P < 0.05), whereas the combination of the baseline risk model with the TyG index yielded an AUC of 0.757 (95% CI: 0.694–0.821; P < 0.05). The TyG index can serve as a predictive indicator for acute respiratory failure in asthma patients, albeit confirmation of these findings requires larger-scale prospective studies.

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Effect of Calcitriol Treated Mesenchymal Stem Cells as an Immunomodulation Micro-environment on Allergic Asthma in a Mouse Model

Ghalavand

Ghaleh

Khafaei

et al. 2023

EMIDDT

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Background: Allergic asthma is a chronic inflammatory illness of the respiratory system characterized by an increase in the number of inflammatory cells in the airways and trouble breathing. Mesenchymal stem cells (MSCs) have the potential to be used in inflammatory diseases as a cellular immunosuppressive treatment. They express calcitriol receptors and communicate with other immunocytes, which increases their anti-inflammatory activity. This study aimed to determine the effects of calcitriol-treated MSC treatment on allergic asthma pathways in a mouse model. Methods: To generate a mouse model of asthma, the mice were sensitized intraperitoneally with ovalbumin (OVA) and aluminum hydroxide emulsion and then challenged intra-nasally with OVA. On day 14, experimental mice received tail vein injections of calcitriol-treated MSCs in PBS prior to allergen exposure. The cytokines assays including IL-4, 10, 12, 17, TGF-β and IFN-γ, splenocytes proliferation, and histological examination of lungs samples were performed. The mice were sensitized with OVA and the response to dexamethasone treatment was compared. Results: Calcitriol-treated MSCs significantly increased the levels of IL-12, TGF-β, and IFN-γ compared to non-treated MSCs groups. Moreover, calcitriol-treated and non-treated MSCs significantly decreased IL-4 and IL-17 compared to asthmatic groups. The results of the histopathological examination showed that calcitriol-treated MSCs reduced the accumulation of inflammatory cells and bronchial wall thickening in comparison with the asthma group. Conclusion: Using the allergic asthma model, we were able to show that calcitriol-treated MSCs had an inhibitory impact on airway inflammation. Our findings suggest that the injection of calcitriol-treated MSCs may be a viable treatment option for allergic asthma.

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Association of Metabolic Syndrome and Asthma Status: A Prospective Study from Guilan Province, Iran

Cited by 3 publications

References 27 publications

Associations between metabolic syndrome and allergic diseases: a nationwide study in Korea and literature review

Associations between metabolic syndrome and allergic diseases: a nationwide study in Korea and literature review

Predictive value of triglyceride-glucose index for the occurrence of acute respiratory failure in asthmatic patients of MIMIC-IV database

Effect of Calcitriol Treated Mesenchymal Stem Cells as an Immunomodulation Micro-environment on Allergic Asthma in a Mouse Model

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