Association of Metabolic Syndrome Parameters with TT3 and FT3/FT4 Ratio in Obese Turkish Population

Tarçın, Özlem; Abanonu, Gul Babacan; Yazıcı, Dilek

doi:10.1089/met.2011.0098

Cited by 56 publications

(62 citation statements)

References 33 publications

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“…Tarcin et al [29] reported higher FT4 levels and lower FT3/FT4 in obese subjects with metabolic syndrome than in those without. This supports the concept that inflammation and adiposity parameters are more associated with changes in thyroid hormone levels than glycaemic levels, as none of the subjects in this study had T2DM.…”

Section: Discussionmentioning

confidence: 97%

The influence of body mass index and low-grade systemic inflammation on thyroid hormone abnormalities in patients with type 2 diabetes

et al. 2013

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The relaTionship between diabetes mellitus (DM) and thyroid hormones (TH) is a complex one. It is known that TH levels affect not only glycaemic control but also hepatic and muscular insulin resistance and play a major role in energy homeostasis [1]. Both hypothyroidism and thyrotoxicosis have been shown to increase insulin resistance [2]. Decompensated hyperthyroidism can worsen glycaemic control and predispose patients to diabetic ketoacidosis [3].On the other hand, patients with DM may show abstract. Previous reports highlight the role of systemic inflammation in the genesis of non-thyroidal illness syndrome and type 2 diabetes mellitus (T2DM). Our objective was to assess whether body mass index and the low-grade systemic inflammation would be associated with changes in thyroid hormone metabolism in patients with type 2 diabetes. This was a cross-sectional study of 104 subjects; 52 patients with type 2 diabetes and 52 in a control group, paired by age, gender and body mass index. We measured total (T) and free (F) thyroxine (T4) and triiodothyronine (T3), reverse T3 (rT3), the ratios FT3/rT3, FT3/FT4 and FT4/rT3, clinical parameters (age, gender, diabetes duration and complications, body mass index, waist circumference, hypertension, HbA1c), and high sensitivity C-reactive protein. Patients with DM presented lower levels of TT4 (p=0.006), TT3 (p<0.001) and FT3 (p<0.001) and higher of FT4 (p<0.001), waist circumference (p=0.047) and C-reactive protein (p<0.001). Body mass index was inversely correlated with FT4 (p=0.036) and TT3 (p=0.008). C-reactive protein was positively correlated with rT3 (p=0.001) and inversely with FT4/rT3 (p<0.001) and FT3/rT3 (p=0.014). Body mass index was an independent predictor for FT4 (B=-0.011, p=0.029) and TT3 levels (B=-1.118, p=0.003). Inflammation predicted the FT4/rT3 ratio (B=-0.190, p<0.001). C-reactive protein (B=0.235, p<0.001) and body mass index (B=-0.008, p=0.047) were independent predictors for rT3. In conclusion, type 2 diabetes was associated with a low T3 state. Body mass index and the low-grade systemic inflammation are related to the non-thyroidal illness syndrome in these patients, possibly by altering the activity of peripheral deiodinases.Key words: Diabetes mellitus, Low T3, Inflammation, Non-thyroidal illness syndrome abnormalities in serum TH levels in the absence of intrinsic disease of the thyroid axis. These are similar to those present in critically ill patients with the non-thyroidal illness syndrome (NTIS), such as low serum triiodothyronine (T3) and thyroxine (T4) levels and elevated reverse T3 (rT3), with concurrent normal serum TSH levels [4,5]. This finding is more frequent in those with poor glycaemic control, especially when HbA1c levels are above 10.5-11% [6] and are reversible upon restoration of adequate metabolic control [7]. Although classically related to glycaemic control, the pathophysiology of TH abnormalities in patients with DM has never been fully investigated. Previous reports highlight the role of systemic inflammation in the genes...

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Section: Discussionmentioning

confidence: 97%

The influence of body mass index and low-grade systemic inflammation on thyroid hormone abnormalities in patients with type 2 diabetes

et al. 2013

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“…On the other hand, thyroid hormone disorders are associated with changes in body composition, and obesity may have an impact on the levels of thyroid hormones as well as the risk of MetS in women (9,29). Tarcin et al (30) showed that MetS positive patients had significantly higher fasting glucose, triglyceride, fT4, BP, and lower HDL and fT3/fT4 ratio than MetS negative patients. In our study, interestingly, MetS parameters, except systolic BP, were correlated with the fT3/fT4 ratio, (HDL negatively), significantly.…”

Section: Discussionmentioning

confidence: 99%

Indices of Central and Peripheral Obesity; Anthropometric Measurements and Laboratory Parameters of Metabolic Syndrome and Thyroid Function

Aras¹,

Üstünsoy²,

Armutçu³

2015

Balkan Med J

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“…Contrary to adults (2,15,18,(31)(32)(33), the role of thyroid hormones in glucose dysmetabolism in otherwise healthy obese children has been examined to a limited extent. In our pediatric population, both BMI-SDS and TSH variations were independently associated with HOMA-IR variation.…”

Section: δBmc-sdsmentioning

confidence: 99%

Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study

Santos

Limbert

Marquês

et al. 2015

Journal of Pediatric Endocrinology and Metabolism

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Background: Serum thyroid stimulating hormone (TSH) levels are frequently elevated in obese children and are most likely to be associated with insulin resistance. However, clinical relevance of this association remains unclear. Objectives: To assess the prevalence of hyperthyrotropinemia; to analyze the relationship between TSH and homeostasis model assessment -insulin resistance (HOMA-IR); and to verify whether TSH levels and HOMA-IR vary with weight loss in obese children. Subjects and Methods: Retrospective longitudinal study with data from baseline and 1 year after lifestyle intervention in a pediatric obese group (344 children were recruited and 100 among them completed follow-up). For postintervention analysis, three groups were considered according to body mass index-standard deviation score (BMI-SDS) variations: ≤ -0.5 (significant weight loss); 0.5-0 (weight loss); and > 0 (weight gain). Statistical analysis was performed using SPSS 19.0

show abstract

Association of Metabolic Syndrome Parameters with TT3 and FT3/FT4 Ratio in Obese Turkish Population

Cited by 56 publications

References 33 publications

The influence of body mass index and low-grade systemic inflammation on thyroid hormone abnormalities in patients with type 2 diabetes

The influence of body mass index and low-grade systemic inflammation on thyroid hormone abnormalities in patients with type 2 diabetes

Indices of Central and Peripheral Obesity; Anthropometric Measurements and Laboratory Parameters of Metabolic Syndrome and Thyroid Function

Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study

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