Association of Metabolic Syndrome with Chronic Kidney Disease in Elderly Japanese Women: Comparison by Estimation of Glomerular Filtration Rate from Creatinine, Cystatin C, and Both

Kurata, Miki; Tsuboi, Ayaka; Takeuchi, Mika; Fukuo, Keisuke; Kazumi, Tsutomu

doi:10.1089/met.2015.0085

Cited by 11 publications

(5 citation statements)

References 36 publications

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“…However, there was no difference in the percentage of women with anemia and CKD G3b between women with and without low grip strength, low SMI and sarcopenia in the present study. We have previously shown in elderly women that the prevalence of CKD was much higher when creatinine-based eGFR was used than the prevalence obtained when cystatin-C based equations were used (46% vs 13%, p < 0.001) 34. This may explain in part why percentage of women with CKD was high (33%) in the present study.…”

Section: Discussioncontrasting

confidence: 50%

Elevated serum adiponectin, elevated tumor necrosis factor-α and decreased transthyretin in Japanese elderly women with low grip strength and preserved insulin sensitivity

Takeuchi

Tsuboi

Minato

et al. 2019

BMJ Open Diab Res Care

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ObjectiveTo determine if serum adiponectin levels are associated with low grip strength and/or low muscle mass in the elderly independently of insulin resistance and inflammation.Research design and methodsCross-sectional associations were analyzed by logistic regression between low grip strength and/or low muscle mass and body composition, elevated serum adiponectin (≥20 mg/L), and biomarkers of nutrition status, insulin resistance and inflammation in 176 community-living Japanese elderly women. Sarcopenia was evaluated using the Asian criteria.ResultsIn bivariate analyses, low grip strength (n=71) was positively associated with age, log tumor necrosis factor-α and hyperadiponectinemia (n=34) and inversely with body weight, height, skeletal muscle mass, serum albumin, transthyretin (TTR), fat mass, serum zinc and hemoglobin (all p<0.01). In a fully adjusted model, TTR (OR 0.90; 95% CI 0.83 to 0.98, p=0.01) in addition to age (p=0.01), height (p<0.001) and skeletal muscle mass (p=0.018) emerged as independent determinants of low grip strength. Mean waist circumference and high-density lipoprotein cholesterol did not differ between women with and without low grip strength and were within the respective normal range. Although hyperadiponectinemia was a single metabolic correlate of low muscle mass (n=87), low serum cholesterol, albumin and TTR in addition to hyperadiponectinemia were associated with sarcopenia (n=45).ConclusionsHyperadiponectinemia, elevated tumor necrosis factor-alpha and decreased TTR, a biomarker of age-related catabolic states, were found in community-living Japanese elderly women with low grip strength and preserved insulin sensitivity although hyperadiponectinemia was a single correlate of low muscle mass.

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Section: Discussioncontrasting

confidence: 50%

Elevated serum adiponectin, elevated tumor necrosis factor-α and decreased transthyretin in Japanese elderly women with low grip strength and preserved insulin sensitivity

Takeuchi

Tsuboi

Minato

et al. 2019

BMJ Open Diab Res Care

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“…A graded relationship has previously been identified between the risk of CKD and the number of components of the MetS present. A cross-sectional study of older adult Japanese community-dwelling women showed that the number of MetS components is associated with the prevalence of CKD in non-obese subjects 31. Moreover, Okada et al found that both early- and late-stage kidney pathology increased with the number of MetS components present and that this association was statistically significant in both normal-weight and overweight individuals 32.…”

Section: Discussionmentioning

confidence: 99%

<p>Metabolic Syndrome Is Associated With Rapid Estimated Glomerular Filtration Rate Decline In A Chinese Community-Based Population</p>

Wu¹,

Jiang²,

Jia³

et al. 2019

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PurposeThis study aimed to determine the relationship between the metabolic syndrome (MetS) and rapid estimated glomerular filtration rate (eGFR) decline in a Chinese community-based population.Patients and methodsA total of 3108 participants were recruited between December 2011 and July 2014 from an observational study cohort designed for the study of atherosclerotic diseases in Beijing, China. The outcome was a rapid eGFR decline. Subgroup and interaction analyses were performed with respect to a number of covariates.ResultsOver a median follow-up period of 2.34 (IQR: 2.29–2.41) years, the overall incidence of rapid eGFR decline was 7.24%. We found that the MetS was significantly associated with the risk of rapid eGFR decline (odds ratio [OR]=1.69, 95% confidence interval [CI]: 1.28–2.23, p<0.001) in a model adjusted for age, sex, and eGFR, and this relationship remained significant after adjustment for smoking, drinking, and low-density lipoprotein-cholesterol (OR=1.78, 95% CI: 1.34–2.35, p<0.001). Waist circumference (OR=1.38, 95% CI: 1.04–1.83, p=0.027), triglycerides (OR=1.40, 95% CI: 1.05–1.86, p=0.022), blood pressure (OR=2.05, 95% CI: 1.49–2.82, p<0.001), and fasting plasma glucose (OR=2.12, 95% CI: 1.57–2.85, p<0.001), but not high-density lipoprotein-cholesterol (OR=1.26, 95% CI: 0.94–1.69, p=0.117), were positively associated with the risk of rapid eGFR decline. Similarly, an increase in the number of MetS components present was associated with an increase in the risk of rapid eGFR decline. Furthermore, this association was modified by smoking status (OR=3.78, 95% CI: 1.68–8.49, p-interaction=0.030).ConclusionThe MetS independently predicted rapid eGFR decline in a Chinese community-based cohort recruited for the study of atherosclerosis. The relationship between the MetS and the risk of rapid eGFR decline was modified by smoking status.

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“…We have previously shown in elderly women that the prevalence of CKD was much higher when creatinine-based eGFR was used than the prevalence obtained when cystatin-C-based equations were used (46% vs 13%, p<0.001). 34 This may explain in part why percentage of women with CKD was high (32%) in the present study.…”

Section: Discussionmentioning

confidence: 65%

Elevated serum adiponectin and tumor necrosis factor-α and decreased transthyretin in Japanese elderly women with low grip strength and preserved muscle mass and insulin sensitivity

Takeuchi

Tsuboi

Minato

et al. 2018

BMJ Open Diab Res Care

Self Cite

View full text Add to dashboard Cite

ObjectiveTo determine if adiponectin levels are associated with low grip strength among the elderly independently of insulin resistance and inflammation.Research design and methodsCross-sectional associations were analyzed by logistic regression between low grip strength and body composition, elevated serum adiponectin (≥20 mg/L), and biomarkers of nutritious stasis, insulin resistance and inflammation in 179 community-living Japanese women. Sarcopenia was evaluated using the Asian criteria.ResultsNo women had sarcopenia. In bivariate analyses, low grip strength (n=68) was positively associated with age, log tumor necrosis factor-α (TNF-α) and hyperadiponectinemia (n=37) and inversely with body weight, height, skeletal muscle mass, serum albumin, transthyretin (TTR), fat mass, serum zinc and hemoglobin (all p<0.01). In a fully adjusted model, TTR (0.90: 0.83–0.98, p=0.01) in addition to age (p=0.007), height (p=0.004) and skeletal muscle mass (p=0.008) emerged as independent determinants of low grip strength. When TTR was removed from the full model, TNF-α was associated with low grip strength (7.7; 1.3–45.8, p=0.02). Mean waist circumference and high-density lipoprotein cholesterol did not differ between women with and without low grip strength and were within the respective normal range. Women with hyperadiponectinemia had higher percentage of women with low grip strength and lower grip strength (both p<0.01).ConclusionsHyperadiponectinemia and elevated TNF-α in addition to decreased TTR, a biomarker of age-related catabolic states, were found in community-living Japanese elderly women with low grip strength and preserved muscle mass and insulin sensitivity.

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Association of Metabolic Syndrome with Chronic Kidney Disease in Elderly Japanese Women: Comparison by Estimation of Glomerular Filtration Rate from Creatinine, Cystatin C, and Both

Cited by 11 publications

References 36 publications

Elevated serum adiponectin, elevated tumor necrosis factor-α and decreased transthyretin in Japanese elderly women with low grip strength and preserved insulin sensitivity

Elevated serum adiponectin, elevated tumor necrosis factor-α and decreased transthyretin in Japanese elderly women with low grip strength and preserved insulin sensitivity

<p>Metabolic Syndrome Is Associated With Rapid Estimated Glomerular Filtration Rate Decline In A Chinese Community-Based Population</p>

Elevated serum adiponectin and tumor necrosis factor-α and decreased transthyretin in Japanese elderly women with low grip strength and preserved muscle mass and insulin sensitivity

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