Association of metabolic syndrome with cardiovascular outcomes in hypertensive patients: a systematic review and meta-analysis

Liu, J; Chen, Y; Cai, Kedan; Gong, Yuhua

doi:10.1007/s40618-021-01603-7

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…A substantial proportion of Taiwan older women are estimated at high risk of metabolic syndrome because women with low socioeconomic status (low level of education or/and incomes) have an increased risk of metabolic syndrome 6 – 8 and that as high as 86% of older women in Taiwan were low-educated (no education, 47.4%; 6 years or less, 38.4%) 9 . Since individuals with metabolic syndrome have increased risks of cardiovascular diseases, type 2 diabetes, cardiovascular and all-cause mortality 10 – 13 , early and effective management/treatment is crucially needed for this specific population.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Efficacy of a multidimensional self-management intervention on low-education women with metabolic syndrome: a cluster randomized controlled trial

Chang

Jeng

et al. 2023

Sci Rep

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Low-education women, a substantially older population, are subject to increased risks of metabolic syndrome and consequent cardiometabolic diseases; early detection and effective management were urgently needed. Ninety-nine women with metabolic syndrome, age 61 and education ≤ 6 years, from four community units were randomly assigned to either a self-management intervention (n = 51) or a control arm (n = 48). The intervention consisted of five dimensions, physical activity and diet modifications (daily exercise classes and two nutrition courses), goal setting, coaching and peer support, problem-solving, and self-monitoring. The control arm received an education leaflet. Assessments were performed at baseline, six months, and 18 months. Compared with the control, the intervention participants improved the overall rate of meeting the recommended servings for six health foods, including vegetables, dairy products, and nuts (except whole grains, fruits, and protein); the rate of meeting regular leisure-time physical activity; and criteria biomarkers—waist circumference, fasting blood glucose, high-density lipoprotein cholesterol (except blood pressure and triglycerides); as well as body weight and body mass index; consequently decreased the number of risk factors and rate of metabolic syndrome. In conclusion, the multidimensional self-management intervention improved physical activity, healthy eating, and metabolic syndrome risks among low-education women with metabolic syndrome.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Efficacy of a multidimensional self-management intervention on low-education women with metabolic syndrome: a cluster randomized controlled trial

Chang

Jeng

et al. 2023

Sci Rep

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“…Also, previous studies showed adverse effects of metabolic syndrome. Accordingly, metabolic syndrome increased the risk of major adverse cardiovascular events by 1.55 times (95% CI: 1.28, 1.87) in patients with hypertension [ 32 ]. Another meta-analysis on eight studies showed that patients with end-stage renal disease and metabolic syndrome had an increased risk of mortality (risk ratio (RR): 1.92; 95% CI: 1.15, 3.21) and CVDs (RR: 6.42; 95% CI: 2.00, 20.58) compared to those without metabolic syndrome [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Association between metabolic syndrome and myocardial infarction among patients with excess body weight: a systematic review and meta-analysis

Sedaghat,

Khodakarim,

Nejadghaderi

et al. 2024

BMC Public Health

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Background Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality worldwide. Controversial views exist over the effects of metabolically unhealthy obesity phenotypes on CVDs. This study aimed to perform a meta-analysis to assess the association between metabolic syndrome and myocardial infarction (MI) among individuals with excess body weight (EBW). Methods We searched PubMed/Medline, Scopus, and Web of Science databases as of December 9, 2023. Cohort studies involving patients with overweight or obesity that reported the relevant effect measures for the association between metabolic syndrome and MI were included. We excluded studies with incomplete or unavailable original data, reanalysis of previously published data, and those that did not report the adjusted effect sizes. We used the Newcastle Ottawa Scale for quality assessment. Random-effect model meta-analysis was performed. Publication bias was assessed by Begg’s test. Results Overall, nine studies comprising a total of 61,104 participants were included. There was a significant positive association between metabolic syndrome and MI among those with obesity (hazard ratio (HR): 1.68; 95% confidence interval (CI): 1.27, 2.22). Subgroup analysis showed higher HRs for obesity (1.72; 1.03, 2.88) than overweight (1.58; 1.-13-2.21). Meta-regression revealed no significant association between nationality and risk of MI (p = 0.75). All studies had high qualities. There was no significant publication bias (p = 0.42). Conclusions Metabolic syndrome increased the risk of MI in those with EBW. Further studies are recommended to investigate other risk factors of CVDs in EBW, in order to implement preventive programs to reduce the burden of CVD in obesity.

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“…Therefore, the number of teeth and PER, which indicate unhealthy periodontal conditions, are part of factors that can be related to MI and affect cardiac evolution. Missing teeth is associated with an increased risk of MI and discriminates patients with high cardiovascular risk [31]; low physical activity with an inadequate diet that produces a metabolic syndrome is associated with a high risk of major adverse cardiovascular events [32]. Furthermore, exercise-based cardiac rehabilitation is essential in cardiac patients' recovery of cardiac patients [33]; a recent cohort study tried to associate the impact of periodontitis and subgingival bacteria on recurrent CVD events such as MI, stroke and death caused by CVD.…”

Section: Discussionmentioning

confidence: 99%

Periodontitis and Other Risk Factors Related to Myocardial Infarction and Its Follow-Up

Seoane

Fernandez-Riejos

Garcia-Rubira

et al. 2022

JCM

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The main issue in the prevention of myocardial infarction (MI) is to reduce risk factors. Periodontal disease is related to cardiovascular disease and both share risk factors. The purpose of this study is to investigate whether periodontitis can be considered a risk factor for MI and common risk factors in a case–control study and in a prospective follow-up study in patients with MI. The test group (MIG) was made up of 144 males who had MI in the previous 48 h. The control group (CG) was composed of 138 males without MI. Both groups were subdivided according to the presence or absence of stage III and IV of periodontitis. General data; Mediterranean diet and physical activity screening; periodontal data; and biochemical, microbiological and cardiological parameters were recorded. ANOVA, Mann–Whitney U and Kruskal–Wallis statistical tests and binary logistic regression analysis were applied. No differences in anthropometric variables were observed between the four groups. The average weekly exercise hours have a higher value in CG without periodontitis. The number of leukocytes was higher in MIG, the number of monocytes was higher in CG and the number of teeth was lower in MIG with periodontitis. Adherence to the Mediterranean diet was higher in CG. Porphyromonas gingivalis and Tannerella forsythia were higher in CG with periodontitis and in MIG with and without periodontitis. At follow-up, the left ventricular ejection fraction (LVEF) data were better in the non-periodontitis group: 15 patients had Mayor Cardiovascular Adverse Events (MACE), 13 of them had periodontitis and 2 did not show periodontitis. Periodontitis, exercise, diet and smoking are risk factors related to MI. MACE presented in the ‘MI follow-up’ shows periodontitis, weight, exercise hours and dyslipidemia as risk factors. LVEF follow-up values are preserved in patients without periodontitis. Our data suggest that periodontitis can be considered a risk factor for MI and MACE in the studied population.

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Association of metabolic syndrome with cardiovascular outcomes in hypertensive patients: a systematic review and meta-analysis

Cited by 6 publications

References 26 publications

RETRACTED ARTICLE: Efficacy of a multidimensional self-management intervention on low-education women with metabolic syndrome: a cluster randomized controlled trial

RETRACTED ARTICLE: Efficacy of a multidimensional self-management intervention on low-education women with metabolic syndrome: a cluster randomized controlled trial

Association between metabolic syndrome and myocardial infarction among patients with excess body weight: a systematic review and meta-analysis

Periodontitis and Other Risk Factors Related to Myocardial Infarction and Its Follow-Up

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